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                               Cytogen Corporation
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CYTOGEN CORPORATION                            650 College Road East, Suite 3100
                                                     Princeton, New Jersey 08540




                                   May 8, 2003

To Our Stockholders:

         You are  cordially  invited  to  attend  the  2003  Annual  Meeting  of
Stockholders of Cytogen Corporation at 11:00 A.M., local time, on Tuesday,  June
10, 2003, at the Radisson Hotel, Route One at Ridge Road, Princeton,  New Jersey
08540.

         The  Notice of  Meeting  and Proxy  Statement  on the  following  pages
describe the matters to be presented at the meeting.

         It is  important  that your shares be  represented  at this  meeting to
assure the presence of a quorum.  Whether or not you plan to attend the meeting,
we hope  that you will  have your  stock  represented  by  signing,  dating  and
returning your proxy in the enclosed envelope,  as soon as possible.  Your stock
will be voted in accordance with the instructions you have given in your proxy.

         Thank you for your continued support.

                                   Sincerely,

                                   /s/ Michael D. Becker

                                   Michael D. Becker
                                   President and Chief Executive Officer





                               CYTOGEN CORPORATION
                        650 College Road East, Suite 3100
                           Princeton, New Jersey 08540


                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                            To Be Held June 10, 2003

         The  Annual  Meeting  of   Stockholders   (the  "Meeting")  of  CYTOGEN
CORPORATION,  a  Delaware  corporation  (the  "Company"),  will  be  held at the
Radisson Hotel, Route One at Ridge Road, Princeton, New Jersey, on Tuesday, June
10, 2003, at 11:00 A.M., local time, for the following purposes:

(1)  To  elect  eight  directors  to serve  until  the next  Annual  Meeting  of
     Stockholders  and until their  respective  successors  shall have been duly
     elected and qualified;

(2)  To amend our 1995 Stock  Option  Plan (the  "1995  Plan") to  increase  the
     maximum  aggregate  number of shares of common stock available for issuance
     thereunder  from 450,263 to 650,263,  and to reserve an additional  200,000
     shares of our common stock for issuance in connection  with such  increase;
     and

(3)  To transact such other  business as may properly come before the Meeting or
     any adjournment or adjournments thereof.

         Holders of Common Stock of record at the close of business on April 28,
2003 are entitled to notice of and to vote at the Meeting, or any adjournment or
adjournments  thereof.  A complete list of such stockholders will be open to the
examination of any stockholder at the Company's  principal  executive offices at
650 College Road East, Suite 3100, Princeton,  New Jersey 08540, for a period of
10 days prior to the  Meeting.  The Meeting may be  adjourned  from time to time
without notice other than by announcement at the Meeting.

         IT IS  IMPORTANT  THAT YOUR  SHARES BE  REPRESENTED  REGARDLESS  OF THE
NUMBER OF SHARES YOU MAY HOLD.  WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING IN
PERSON,  PLEASE  COMPLETE,  DATE AND SIGN THE  ENCLOSED  PROXY  CARD AND MAIL IT
PROMPTLY IN THE  ENCLOSED  RETURN  ENVELOPE.  THE PROMPT  RETURN OF PROXIES WILL
ENSURE A QUORUM AND SAVE THE COMPANY THE EXPENSE OF FURTHER  SOLICITATION.  EACH
PROXY  GRANTED MAY BE REVOKED BY THE  STOCKHOLDER  APPOINTING  SUCH PROXY AT ANY
TIME BEFORE IT IS VOTED.  IF YOU RECEIVE  MORE THAN ONE PROXY CARD  BECAUSE YOUR
SHARES ARE  REGISTERED  IN DIFFERENT  NAMES OR  ADDRESSES,  EACH SUCH PROXY CARD
SHOULD BE SIGNED AND RETURNED TO ASSURE THAT ALL OF YOUR SHARES WILL BE VOTED.



                                      By Order of the Board of Directors

                                      /s/ Rita Auld

                                      Rita Auld
                                      Secretary
Princeton, New Jersey
May 8, 2003

        The Company's 2002 Annual Report accompanies the Proxy Statement.


                               CYTOGEN CORPORATION
                        650 College Road East, Suite 3100
                           Princeton, New Jersey 08540

--------------------------------------------------------------------------------
                                 PROXY STATEMENT
--------------------------------------------------------------------------------

         This Proxy Statement is furnished in connection  with the  solicitation
by the Board of Directors of Cytogen Corporation (also referred to in this Proxy
Statement as the "Company",  "Cytogen",  "we" or "us") of proxies to be voted at
our Annual Meeting of Stockholders  to be held on Tuesday,  June 10, 2003 at the
Radisson Hotel,  Route One at Ridge Road,  Princeton,  New Jersey at 11:00 a.m.,
local time, and at any adjournment or adjournments thereof. Holders of record of
our common stock, $.01 par value per share, as of the close of business on April
28,  2003,  will be entitled to notice of and to vote at the Annual  Meeting and
any adjournment or adjournments  thereof.  As of that date, there were 8,813,832
shares of common stock issued and  outstanding  and entitled to vote. Each share
of common  stock is entitled to one vote on any matter  presented  at the Annual
Meeting.  The aggregate  number of common stock votes entitled to be cast at the
Annual  Meeting is 8,813,832.  The holders of common stock will vote as a single
class for all proposals.

         If proxies in the accompanying form are properly executed and returned,
the  shares of common  stock  represented  thereby  will be voted in the  manner
specified  therein.  If not  otherwise  specified,  the  shares of common  stock
represented by the proxies will be voted:

          (i)  FOR, the election of the eight nominees named below as directors;

          (ii) FOR, a proposal  to amend our 1995 Stock  Option  Plan (the "1995
               Plan") to  increase  the  maximum  aggregate  number of shares of
               common stock  available for issuance  thereunder  from 450,263 to
               650,263,  and to  reserve  an  additional  200,000  shares of our
               common stock for issuance in  connection  with such increase; and

          (iii)in the  discretion  of the persons  named in the enclosed form of
               proxy,  on any other proposals which may properly come before the
               Annual Meeting or any adjournment or adjournments thereof.

         Any  stockholder  who has  submitted  a proxy may revoke it at any time
before it is voted, by written notice addressed to and received by our Corporate
Secretary,  by  submitting  a duly  executed  proxy  bearing a later  date or by
electing  to vote in person at the  Annual  Meeting.  The mere  presence  at the
Annual Meeting of the person  appointing a proxy does not,  however,  revoke the
appointment.

         The presence, in person or by proxy, of holders of shares of our common
stock in the aggregate having a majority of the votes entitled to be cast by the
holders of common stock at the Annual  Meeting,  shall  constitute a quorum with
respect to all  matters  presented.  The  affirmative  vote by the  holders of a
plurality of the shares of common  stock  represented  at the Annual  Meeting is
required for the election of directors,  provided a quorum of such  stockholders
is present  in person or by proxy.  All  actions,  other  than the  election  of
directors,  may be taken upon the affirmative vote of stockholders  possessing a
majority  of the  requisite  voting  power  represented  at the Annual  Meeting,
provided a quorum is present in person or by proxy.

         Abstentions  are included in the shares  present at the Annual  Meeting
for purposes of  determining  whether a quorum is present,  and are counted as a
vote against for purposes of determining whether a proposal is approved.  Broker
non-votes  (when  shares  are  represented  at the  Annual  Meeting  by a  proxy
specifically conferring only limited authority to vote on certain matters and no
authority to vote on other  matters) are  included in the  determination  of the
number of shares  represented  at the Annual Meeting for purposes of determining
whether a quorum is present,  but are not counted  for  purposes of  determining
whether a proposal has been approved and thus have no effect on the outcome.

         This Proxy  Statement,  together  with the related proxy card, is being
mailed  to our  stockholders  on or about  May 8,  2003.  The  Annual  Report to
Stockholders  of the Company for the year ended  December  31,  2002,  including
financial statements,  is being mailed together with this Proxy Statement to all
stockholders  of record as of April 28,  2003.  In  addition,  we have  provided
brokers,  dealers,  banks,  voting trustees and their nominees,  at our expense,
with  additional  copies of the Annual  Report and proxy  materials so that such
record holders could supply such materials to beneficial  owners as of April 28,
2003.



                              ELECTION OF DIRECTORS

         At the Annual Meeting,  eight directors are to be elected (which number
shall  constitute  our entire Board of  Directors) to hold office until the 2004
Annual  Meeting of  Stockholders,  and until  their  successors  shall have been
elected and  qualified.  The holders of common  stock,  voting as a class,  will
elect each such director.

         It is the  intention of the persons named in the enclosed form of proxy
to vote the stock represented thereby,  unless otherwise specified in the proxy,
for the election as directors of the persons whose names and biographies  appear
below. All such persons, except Mr. Bloom, are, at present, members of our Board
of  Directors.  To  accommodate  the  addition  of Mr.  Bloom  to our  Board  of
Directors,  our Board of Directors has amended our Bylaws to permit a Board size
of eight members and has increased the size of our Board from seven to eight. In
the event any of the nominees should become  unavailable or unable to serve as a
director,  it is  intended  that  votes  will be cast for a  substitute  nominee
designated  by our Board of  Directors.  Our Board of Directors has no reason to
believe that the nominees named will be unable to serve if elected.  Each of the
nominees has  consented to being named in this Proxy  Statement  and to serve if
elected.

         The nominees for election to our Board of Directors are as follows:


                                                         Served as a                    Positions with
                  Name                      Age         Director Since                   the Company
-------------------------------------       ---         --------------       ----------------------------------
                                                                    
James A. Grigsby.....................       60               1996            Chairman of the Board

Michael D. Becker....................       34               2002            President, Chief Executive Officer
                                                                             and Director

John E. Bagalay, Jr..................       69               1995            Director

Allen Bloom(1).......................       59                --             --

Stephen K. Carter....................       65               1998            Director

Robert F. Hendrickson................       70               1995            Director

Kevin G. Lokay.......................       46               2001            Director

H. Joseph Reiser.....................       56               1998            Director


(1)  Mr. Bloom is the only nominee who has not previously served on our Board of
     Directors.

         The principal  occupations  and business  experience,  for at least the
past five years, of each nominee are as follows:

         James A.  Grigsby has served on our Board of  Directors  since May 1996
and has served as Chairman of the Board since June 1998.  Mr. Grigsby has served
as President and principal  owner of Grigsby & Smith,  a financial  planning and
investment  management  firm  located  in  Pittsfield,  MA since  January  2002.
Previously,  Mr.  Grigsby  was  President  of  Cancer  Care  Management  LLC,  a
consulting  firm  providing   consulting   services   regarding  cancer  disease
management  issues.  From  1989 to 1994,  Mr.  Grigsby  was  President  of CIGNA
Corporation's  International Life and Employee Benefits Division, which operated
in over 20  countries  worldwide,  and previous to that period he also served as
the head of CIGNA's national health care sales force.  Prior to that time, since
1978,  he held a number of  executive  positions  with  CIGNA  Corporation.  Mr.
Grigsby received a Bachelor of Arts degree in Mathematics from Baylor University
and is a Fellow of the Society of Actuaries.

         Michael D. Becker currently serves as our President and Chief Executive
Officer.  Mr. Becker joined Cytogen in April 2001 and has served in positions of
increasing  responsibility,  including Chief Executive  Officer of the Company's
AxCell Biosciences subsidiary, Vice President, Business Development and Industry
Relations,  and Vice President,  Investor  Relations  Officer.  Prior to joining
Cytogen,  he was with Wayne Hummer  Investments  LLC, a  Chicago-based  regional
brokerage firm from July 1996 to April 2001, where he held senior positions as a
biotechnology analyst, investment executive and portfolio manager in addition to
participating in sales management  activities.  From October 1998 to April 2001,
Mr.  Becker  also  served  on the board of  directors  for the  Chicago  Biotech
Network,  a  nonprofit  trade  association  for the  biotechnology  industry  in
Illinois. Mr. Becker attended DePaul University in Chicago, Illinois.

                                       2


         John E. Bagalay, Jr. has served on our Board of Directors since October
1995.  Dr. Bagalay was a director of Cellcor,  Inc. prior to our  acquisition of
Cellcor in October 1995. He was our interim  President and CEO from January 1998
to  September  1998,  and our  Chief  Financial  Officer  from  October  1987 to
September 1988. He has been Senior Advisor to the Chancellor,  Boston University
since  January  1998.  He was a  director,  Chief  Operating  Officer  and Chief
Financial  Officer of Eurus  Technologies,  Inc.  from January 1999 until August
2001 and Chief  Executive  Officer from  October 2000 until August 2001.  He has
been a Director and Finance Director of Eurus  International  Limited, a company
organized under the laws of England and Wales,  since January 2000. He served as
the Managing  Director of the Community  Technology  Fund,  the venture  capital
affiliate of Boston  University,  from  September  1989 until January 1998.  Dr.
Bagalay  has also  served as  General  Counsel  for Texas  Commerce  Bancshares,
Houston First  Financial Group and Lower Colorado River  Authority,  a regulated
electric  utility.  Dr. Bagalay currently also serves on the boards of directors
of Wave  Systems  Corporation  and  Decorize,  Inc. and several  privately  held
companies.  Dr. Bagalay holds a B.A. in Politics,  Philosophy  and Economics,  a
Ph.D.  in  Political  Philosophy  from  Yale  University,  and a J.D.  from  the
University of Texas.

         Allen Bloom,  a patent  attorney,  has been a partner at Dechert LLP, a
law firm, since 1994 where he is Co-Chair of the Intellectual Property Group and
heads a patent  practice group which focuses on  biotechnology,  pharmaceuticals
and medical  devices.  For the nine years prior thereto,  he was Vice President,
General  Counsel and Secretary of The Liposome  Company,  Inc., a  biotechnology
company.  His responsibilities  there included patent,  regulatory and licensing
activities.  Dr.  Bloom  holds a Ph.D.  in  Organic  Chemistry  from Iowa  State
University,  a J.D. degree from New York Law School and a B.S. in Chemistry from
Brooklyn College.

          Stephen K. Carter has served on our Board of Directors since September
1998.  Since  1997,  Dr.  Carter  has been a  consultant  to the  pharmaceutical
industry.  Dr. Carter was Senior Vice  President of Research and  Development at
Boehringer Ingelheim  Pharmaceuticals,  Inc. from 1995 to 1997. Prior to joining
Boehringer,  Dr. Carter was Senior Vice President of Worldwide Clinical Research
and Development at Bristol-Myers  Squibb Company.  From 1976 to 1982, Dr. Carter
served as Director of the Northern  California Cancer Institute.  Dr. Carter was
also  appointed  to President  Clinton's  panel for AIDS drug  development.  Dr.
Carter  is a  director  of Allos  Therapeutics,  Alfacell  Corporation  and Vion
Pharmaceuticals  Inc.  Dr.  Carter  received  an A.B. in History  from  Columbia
College  and an M.D.  from New York  Medical  College.  He  completed  a medical
internship and residency at Lenox Hill Hospital.

         Robert F. Hendrickson has served on our Board of Directors since  March
1995.  Since 1990, Mr.  Hendrickson has been a consultant to the  pharmaceutical
and biotechnology  industries on strategic  management and manufacturing  issues
with a number of leading biotechnology companies among his clients. Prior to his
retirement in 1990, Mr. Hendrickson was Senior Vice President, Manufacturing and
Technology  for Merck & Co.,  Inc.  He is  currently  a trustee  of the  Carrier
Foundation  and  previously   served  as  a  director  of  a  number  of  public
biotechnology  companies  including  Liposome,  Inc.  and  Envirogen,  Inc.  Mr.
Hendrickson  received  an A.B.  degree  from  Harvard  College  and a Masters of
Business   Administration   from  the  Harvard   Graduate   School  of  Business
Administration.

         Kevin G. Lokay has served on our Board of Directors since January 2001.
Mr.   Lokay  is   currently   Vice   President,   Oncology  at   GlaxoSmithKline
Pharmaceuticals.  Prior to joining  GlaxoSmithKline  in 1997, Mr. Lokay spent 16
years with Merck & Co.,  where his most recent  assignment  was Vice  President,
Worldwide Sales,  Marketing and Development in the Merck Vaccine  Division.  Mr.
Lokay joined Merck in 1981 as a sales  representative,  and  progressed  through
numerous  positions of increasing  responsibilities  in sales,  market research,
advertising,   product  management,  and  business  development,  while  gaining
experience in a wide variety of therapeutic areas, including  antihypertensives,
antiarrythmics, antibiotics, analgesic/anti-inflammatories,  psychotherapeutics,
vaccines,  and  gastro-intestinal  products.  Mr.  Lokay  is a  director  of the
University  of  Sciences,  Philadelphia,  Pennsylvania.  He holds a  Masters  of
Business  Administration  with a  concentration  in Marketing  from the Krannert
School of Management at Purdue  University,  and a Bachelor of Arts in Economics
from Lafayette College.

         H. Joseph Reiser  has served on  our Board of  Directors  since  August
1998. Dr. Reiser is currently President, Chief Executive Officer and Director of
Locus  Pharmaceuticals.  Most  recently,  Dr. Reiser served as our President and
Chief  Executive  Officer from August 1998 until  December  2002. Dr. Reiser was


                                       3


also Corporate Vice President and General Manager,  Pharmaceuticals and a member
of the board of directors,  for Berlex Laboratories Inc., the U.S. subsidiary of
Schering AG from 1981 to 1998.  During his 17 year tenure at Berlex,  Dr. Reiser
held positions of increasing  responsibility,  serving as the first President of
Schering Berlin's Venture Corporation,  Vice President,  Technology and Industry
Relations, and Vice President, Drug Development and Technology.  Previously, Dr.
Reiser also served on the boards of Endeavor Pharmaceuticals and Personal Health
Technologies Inc. and as Chairman of the New Jersey  Biotechnology  Council from
2001 to  2002.  Dr.  Reiser  received  his  Ph.D.  in  Physiology  from  Indiana
University School of Medicine,  where he also earned his Masters and Bachelor of
Science degrees.

         All  directors  will hold  office  until  our next  annual  meeting  of
stockholders  and until  their  successors  shall  have been  duly  elected  and
qualified.  None of our directors are related to any other director or to any of
our executive officers.

         The Board of Directors  recommends that  stockholders  vote FOR each of
the nominees  for the Board of  Directors.  Please note that  proxies  cannot be
voted for a greater number of persons than the nominees named above.

Committees and Meetings of the Board

         Our Board of  Directors  currently  consists of James A.  Grigsby,  who
serves as Chairman of the Board, Michael D. Becker, John E. Bagalay,  Stephen K.
Carter, Robert F. Hendrickson, Kevin G. Lokay and H. Joseph Reiser. There were 9
meetings of the Board of Directors  during 2002.  During  2002,  each  incumbent
director,  except for Mr.  Lokay,  attended at least 75% of the aggregate of all
meetings of the Board of Directors  held during the period in which he served as
a director  and the total number of meetings  held by the  committee on which he
served during the period, if applicable.

         There are currently three  committees of the  Board  of Directors:  the
Compensation  Committee,  the  Nominating  Committee  and the Audit and  Finance
Committee.

The Compensation Committee

         The Compensation Committee currently consists of Robert F. Hendrickson,
who serves as  Chairman,  and Kevin G. Lokay.  The  Compensation  Committee  was
established in 1986 and held 3 meetings in 2002. The primary responsibilities of
the Compensation  Committee include  overseeing the  administration of our stock
option plans, recommending compensation for our executive officers and other key
employees to the Board of Directors  and generally  reviewing  our  compensation
policy.

The Nominating Committee

         The Nominating  Committee  currently consists of James A. Grigsby,  who
serves as  Chairman,  and  Michael  D.  Becker.  The  Nominating  Committee  was
established  in 1994  and  did not  hold  any  meetings  in  2002.  The  primary
responsibility  of the  Nominating  Committee is  investigating,  recruiting and
interviewing  potential  candidates for election to the Board of Directors.  The
Nominating Committee will consider nominees for the Board of Directors suggested
by stockholders whose names are submitted in writing to the Nominating Committee
in care of the office of our Corporate Secretary.

The Audit and Finance Committee

         The Audit and Finance Committee  currently consists of John E. Bagalay,
Jr., who serves as Chairman,  Robert F.  Hendrickson and Stephen K. Carter.  The
Audit and Finance Committee was established in 1986 and held 5 meetings in 2002.
The primary  responsibilities  of the Audit and Finance Committee  include:  (i)
evaluating  and  recommending  to our Board of Directors  the  engagement of our
independent  auditors;  (ii)  reviewing  the  results and scope of the audit and
other services  provided by our independent  auditors;  and (iii) monitoring and
consulting  with  the  independent   auditors  and  management   regarding  risk
management,  the adequacy of financial and  accounting  procedures  and internal
controls on a periodic basis.  The Audit and Finance  Committee also reviews and
monitors our  financial  planning and  financial  structure to  accommodate  our
operating  requirements and strategic  objectives.  The  responsibilities of the
Audit and  Finance  Committee  are more fully set forth in the Audit and Finance
Committee  Charter adopted by the Audit and Finance Committee on May 16, 2000, a
copy of which was filed as an  Appendix  to our Proxy  Statement  filed with the
Securities and Exchange Commission on April 30, 2001.


                                       4


         The Nasdaq  National  Market has adopted  requirements  relating to the
independence  of  members of the audit  committees  of  companies  traded on the
market.  Our Audit and Finance  Committee  members meet the requirements of that
rule.

         Each Audit and Finance Committee member is an independent member of our
Board of Directors as defined in Rule 4200(a)(14) of the National Association of
Securities Dealers' listing standards.  As an independent  director of our Board
of  Directors,  each  Audit and  Finance  Committee  member is not an officer or
employee of the  Company or our  subsidiaries  and does not have a  relationship
which,  in the  opinion of our Board of  Directors,  would  interfere  with that
person's exercise of independent  judgment in carrying out the  responsibilities
of a director.

Report of the Audit and Finance Committee

March 28, 2003

To the Board of Directors of Cytogen Corporation:

         We have reviewed and discussed with  management  the Company's  audited
financial statements as of and for the year ended December 31, 2002.

         Management  is  responsible  for the  Company's  internal  controls and
financial  reporting  process.  The  Company's  independent  auditors,  KPMG LLP
("KPMG") are  responsible  for performing an independent  audit of the Company's
consolidated   financial   statements  in  accordance  with  auditing  standards
generally  accepted  in the United  States of  America  and to issue a report on
those consolidated financial statements.  As appropriate,  the Audit and Finance
Committee  reviews,  evaluates  and  discusses  with the  Company's  management,
internal accounting and financial personnel and KPMG, the following:

     -    the plan  for,  and  KPMG's  report  on,  the  audit of the  Company's
          financial statements;

     -    the Company's financial disclosure documents,  including all financial
          statements   and  reports  filed  with  the  Securities  and  Exchange
          Commission or sent to stockholders;

     -    management's   selection,   application  and  disclosure  of  critical
          accounting policies;

     -    changes in the Company's accounting practices, principles, controls or
          methodologies;

     -    significant  developments or changes in accounting rules applicable to
          the Company; and

     -    the  adequacy  of the  Company's  internal  controls  and  accounting,
          financial and auditing personnel.

         We have  discussed  with KPMG the matters  required to be  discussed by
Statement on Auditing Standards No. 61, Communication with Audit Committees,  as
amended,  by the Auditing Standards Board of the American Institute of Certified
Public  Accountants  ("SAS 61").  SAS 61 requires KPMG to discuss with the Audit
and Finance Committee, among other things, the following:

     -    methods to account for significant unusual transactions;

     -    the effect of  significant  accounting  policies in  controversial  or
          emerging areas for which there is a lack of authoritative  guidance or
          consensus;

     -    the process used by management in formulating  particularly  sensitive
          accounting  estimates and the basis for KPMG's  conclusions  regarding
          the reasonableness of those estimates; and


                                       5

     -    disagreements  with  management  over the  application  of  accounting
          principles,  the basis for management's  accounting  estimates and the
          disclosures in the financial statements.

         We have received,  reviewed and discussed the written  disclosures  and
the letter from KPMG required by  Independence  Standards  Board Standard No. 1,
Independence Discussions with Audit Committees,  as amended, by the Independence
Standards  Board  ("Independence  Standards  Board  Standard  No. 1"),  and have
discussed with KPMG their  independence.  Independence  Standards Board Standard
No. 1 requires auditors  annually to disclose in writing all relationships  that
in the  auditor's  professional  opinion  may be  reasonably  thought to bear on
independence, confirm their perceived independence and engage in a discussion of
independence.

         We have considered  whether the non-audit services provided by KPMG, as
set forth in the section of our Proxy Statement entitled "Independent  Auditor's
Fees and Other Matters," are compatible with maintaining KPMG's independence.

         Based on the reviews and discussions referred to above, we recommend to
the Board of  Directors  that the  audited,  consolidated  financial  statements
referred to above be included in the  Company's  Annual  Report on Form 10-K for
the year ended December 31, 2002.

John E. Bagalay, Jr.
Audit and Finance Committee Chairman

Stephen K. Carter
Audit and Finance Committee Member

Robert F. Hendrickson
Audit and Finance Committee Member

Independent Auditor's Fees and Other Matters

Audit Fees

         Fees for professional  services rendered by KPMG in connection with the
audit of our  financial  statements  for the  most  recent  fiscal  year and the
reviews of the financial statements included in each of our Quarterly Reports on
Form 10-Q during the fiscal year ended December 31, 2002 aggregated $99,200.

Financial Information Systems Design and Implementation Fees

         During the year ended  December 31, 2002 KPMG did not provide  services
that related to financial information systems design and implementation.

Audit Related Fees

         Fees for audit related services consisting  principally of the audit of
our employee benefit plan and certain accounting consultation aggregated $23,000
for the year ended December 31, 2002.

Tax Fees

         Fees  for  professional   services   relating  to  tax  compliance  and
consultation aggregated $11,500 for the year ended December 31, 2002.

Directors' Compensation

         Each of our  non-employee  directors  receives  an annual  retainer  of
$12,000,  plus $1,500 for each board meeting  attended ($500 if participation is
by  telephone).  Any  non-employee  director  who also chairs a board  committee
receives an additional annual fee of $2,000. Non-employee directors receive $500
for each  committee  meeting  attended,  but receive no additional  retainer for
committee  membership.  Members of the  Nominating  Committee do not receive any


                                       6


compensation  for serving on that  committee.  The Chairman of the Board (who is
not an employee of the Company) currently receives,  based upon significant time
spent on Company  business,  an  additional  annual  retainer  of  $50,000.  The
additional  retainer  contemplates  four days per month  substantially  given to
Company  business  by the  Chairman.  An amount of $1,500 per day is paid to the
Chairman for additional days in which the significant part of the day is devoted
to Company  matters.  During 2002,  the  Chairman  received  $50,000  under this
arrangement.

         Pursuant to our 1999 Non-Employee  Director Plan (the "Director Plan"),
each  non-employee  director receives an initial grant of options on the date of
appointment  equal to a pro-rata  portion of 2,000  shares of our common  stock,
based upon the number of months  remaining  from the date of election  until the
one year  anniversary of the preceding annual meeting.  In addition,  on the day
following  each  annual  meeting of the  stockholders,  each  individual  who is
elected as a non-employee  director shall  automatically  be granted  options to
purchase 1,000 shares of our common stock. The Chairman of the Board, unless the
Compensation  Committee  determines  otherwise,  receives an additional grant of
1,500 options to purchase  shares of our common stock on the date of each annual
meeting.  Options  granted  under the Director Plan are  exercisable  at a price
equal to the  average  of the high and low sale  prices of the  common  stock as
reported  on the  Nasdaq  National  Market on the date of grant and vest in full
(i.e.,  first become  exercisable) at the first  anniversary of the option grant
date. Each director's  outstanding  options granted under the Director Plan also
become  immediately  exercisable in full: (i) upon the occurrence of a change of
control of the Company; (ii) upon death or disability; or (iii) upon resignation
or retirement after age 55.

         In  addition,   at  the  2001  Annual  Meeting  of  Stockholders,   our
stockholders  adopted a proposal  to amend the  Director  Plan to  provide  that
non-employee directors shall receive, at the sole discretion of and after formal
action by our Board of Directors,  such number of shares of common stock that is
equal to each such director's cash compensation (including,  but not limited to,
annual service fees, fees payable for board and committee  meetings attended and
fees for committees chaired), (the "Cash Component"), divided by the fair market
value of our  common  stock  as of the date of  issuance  of such  shares,  (the
"Compensation  Shares"),  which date shall be no earlier  than the date on which
the  applicable  Cash  Component  compensation  becomes  due and  payable by us.
Compensation  Shares  shall not be issued for  services not yet rendered by such
directors to the Company.  Such  amendments to the Director Plan further provide
that in the event the board elects to issue Compensation  Shares,  such eligible
directors  shall receive  Compensation  Shares until,  absent  additional  board
action,  at least  such time as: (i) such  director  owns two  thousand  (2,000)
shares of our common stock,  excluding options or other rights to acquire shares
of our common stock, whether exercisable or unexercisable; or (ii) if fewer than
2,000 shares are so owned, such smaller number of shares has a fair market value
of in excess of one hundred thousand dollars ($100,000), excluding the value, if
any, of options to purchase common stock,  whether exercisable or unexercisable,
or other  rights to acquire  our common  stock.  Upon  achieving  either of such
milestones  (i) or (ii)  above,  each such  director  may, at his or her option,
elect  to  cease  receiving  his or her  Cash  Component  to  which he or she is
entitled  in shares of our  common  stock  under the  Director  Plan;  provided,
however,  that such director must make such election by providing notice of such
election to us in a timely manner.  In October 2001, our Board of Directors took
appropriate  actions to  implement  the  payment  of  director  compensation  in
Compensation  Shares.  As of the date  hereof,  all of our current  non-employee
directors have satisfied  either of the milestones as set forth above,  and have
elected to receive their director compensation in cash.

         Each  option  provided  for in  the  Director  Plan  shall  be  granted
automatically  and without  further  action by us, our Board of Directors or our
stockholders.  Promptly  after the date of grant of each option  provided for in
the  Director  Plan,  we shall  cause an option  agreement  to be  executed  and
delivered  to the holder of the option.  No other  options may be granted at any
time under the Director Plan.


                                       7



                      EXECUTIVE OFFICERS AND KEY EMPLOYEES

         Our current  executive  officers and key employees and their respective
ages and positions with us are as follows:



                                                         Capacities In                         In Current
             Name                     Age                 Which Served                       Position Since
-----------------------------         ---        -------------------------------    -------------------------------
                                                                           
Michael D. Becker(1).........          34        President, Chief Executive         December 2002
                                                 Officer and Director               (Vice President of Business
                                                                                    Development and Industry
                                                                                    Relations from October 2002 to
                                                                                    December 2002; and Interim
                                                                                    Chief Executive Officer of
                                                                                    AxCell BioSciences Corporation
                                                                                    since January 2002)

William F. Goeckeler.........          47        Vice President, Operations         January 2003
                                                                                    (Vice President of Research and
                                                                                    Development from June 2001 to
                                                                                    January 2003)

Deborah A. Kaminsky..........          48        Vice President of Business         January 2003
                                                 Development                        (Vice President of Sales and
                                                                                    Marketing from June 2001 to
                                                                                    January 2003)

Thu A. Dang(2)...............          42        Vice President, Finance            January 2003
                                                                                    (Director of Finance from May
                                                                                    2000 to January 2003)

Rita Auld(2).................          55        Vice President of Human            January 2003
                                                 Resources and Administration and   (Director of Human Resources
                                                 Corporate Secretary                from October 2000 to January
                                                                                    2003; Corporate Secretary since
                                                                                    March 2003)


(1)    Mr. Becker's  biographical information  appears  above,  see "ELECTION OF
       DIRECTORS".

(2)    Not an executive officer.

         William F.  Goeckeler  was promoted to Vice  President,  Operations  in
January  2003.  Previously,  he served as our Vice  President  of  Research  and
Development since June 2001. He joined Cytogen in March of 1994 as the Assistant
Director,  Pharmaceutical  Development.  In 1995 he was  promoted  to  Associate
Director,  Technical  Support  Operations  and in June 1997 became our Director,
Pharmaceutical  Development,  a position he held until June 2001. Before joining
us, Dr. Goeckeler spent nine years as a scientist in the Bioproducts  Laboratory
of Central Research and Development at The Dow Chemical  Company.  Dr. Goeckeler
did his  undergraduate  and graduate work at the University of Missouri where he
received his Ph.D. in Radiochemistry for research that involved the discovery of
Quadramet.

         Deborah A. Kaminsky, D.Ph. has served as our Vice President of Business
Development  since January 2003. Most recently,  Ms. Kaminsky served as our Vice
President of Sales and Marketing since June 2001. She joined Cytogen in December
2000 as Director of Marketing.  Prior to joining Cytogen, Dr. Kaminsky spent two
years  with  Imagyn   Medical   Technologies   as  Vice  President  of  Clinical
Development,  having previously spent more than a decade at Syncor International
Corporation where she held positions of increasing  responsibility  ranging from
pharmacy   management  to  business   development  and  president  of  a  Syncor
subsidiary. She received academic degrees from the University of Oklahoma Health
Sciences  Center  College  of  Pharmacy  and  the  Kellogg  Graduate  School  of
Management at Northwestern University, and holds a Doctor of Pharmacy license in
Oklahoma.


                                       8


         Thu A. Dang was  promoted  to Vice President, Finance in January  2003.
Ms. Dang joined  Cytogen in  September  1988 as our Senior  Financial  Reporting
Accountant,  and was  promoted  to  Director  of Finance  in May 2000.  Prior to
joining Cytogen,  Ms. Dang held numerous  positions with Harrisburg  Dairies for
six years,  serving  ultimately as their Controller.  In such capacity,  she was
responsible for converting an outdated accounting system,  establishing controls
for accounting and data processing functions.  Ms. Dang received her Bachelor of
Science Degree in Accounting from Elizabethtown College.

         Rita A.  Auld was  promoted  to Vice  President,  Human  Resources  and
Administration in January 2003 and became our Corporate Secretary in March 2003.
Ms. Auld joined Cytogen as our Director of Human  Resources in October 2000. For
a period of six years prior to joining  Cytogen,  Ms.  Auld was the  Director of
Human  Resources  of  Flexpaq  Corporation,  where  she  established  the  Human
Resources Department,  developing  procedures,  handbooks and benefit and safety
programs.  Ms. Auld has over 20 years of experience  with sales,  manufacturing,
accounting  and  engineering  organizations,  directing the  activities of human
resources and administrative  functions,  specializing in small sized companies,
both public and  private.  Ms.  Auld holds  Associates  and  Bachelor of Science
Degrees  in  Business  Administration  and is  certified  as a  Human  Resources
Professional.

         The  current  key  employee  of  our  subsidiary,   AxCell  BioSciences
Corporation, is as follows:



                                                             Capacities In                  In Current
             Name                     Age                    Which Served                 Position Since
-----------------------------         ---        -------------------------------          --------------
                                                                                  
Michael D. Becker(1).........          34        Interim Chief Executive Officer           January 2002


(1)  Mr.  Becker's  biographical  information  appears  above,  see "ELECTION OF
     DIRECTORS".

         None of  Cytogen's or AxCell's  executive  officers,  key  employees or
directors is related to any other of Cytogen's or AxCell's  executive  officers,
key employees or directors.  Our executive  officers are elected annually by the
Board of  Directors  and serve  until  their  successors  are duly  elected  and
qualified.  AxCell's key  employees  are elected  annually by AxCell's  Board of
Directors and serve until their successors are duly elected and qualified.

Section 16(a) Beneficial Ownership Reporting Compliance

         Section  16(a) of the  Securities  Exchange  Act of 1934,  as  amended,
requires our directors, executive officers and stockholders who beneficially own
more than 10% of any  class of our  equity  securities  registered  pursuant  to
Section 12 of the Exchange Act, to file initial reports of ownership and reports
of  changes  in  ownership  with  respect  to our  equity  securities  with  the
Securities and Exchange  Commission.  All reporting  persons are required by SEC
regulation to furnish us with copies of all reports that such reporting  persons
file with the SEC pursuant to Section 16(a).

         Based solely on our review of the copies of such forms  received by us,
except as described  below,  each such  reporting  person has filed all of their
respective reports pursuant to Section 16(a) on a timely basis.

         Deborah  Kaminsky failed to timely file a Form 4 relating to a grant of
options to purchase  6,237 shares of our common stock on December 17, 2002.  Ms.
Kaminsky filed such Form 4 with the SEC on March 19, 2003.

         William Goeckeler failed to timely file a Form 4 relating to a grant of
options to purchase  7,000 shares of our common stock on December 17, 2002.  Mr.
Goeckeler  filed a Form 4 with  respect  to such grant with the SEC on March 19,
2003.


                                       9



                             EXECUTIVE COMPENSATION

Summary of Compensation in Fiscal 2002, 2001 and 2000

         The  following  Summary   Compensation  Table  sets  forth  information
concerning  compensation during the years ended December 31, 2002, 2001 and 2000
for services in all capacities  awarded to, earned by or paid to each person who
served as our Chief Executive Officer at any time during 2002, each other of our
executive officers as of December 31, 2002 and certain individuals who served as
our or AxCell's  executive  officers during a part of 2002, whose aggregate cash
compensation  exceeded $100,000 at the end of 2002 (collectively  referred to as
the "Named Executives").




                                                     SUMMARY COMPENSATION TABLE
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                   Long-Term
                                                         Annual Compensation(1)                   Compensation
                                            -----------------------------------------------          Awards
                                                                                Other              Securities
  Name and Principal Position                                                   Annual             Underlying          All Other
                                    Year        Salary        Bonus(2)      Compensation(3)          Options        Compensation(4)
                                                  ($)            ($)              ($)                  (#)                ($)
              (a)                   (b)           (c)            (d)              (e)                  (g)                (i)
------------------------------------------------------------------------------------------------------------------------------------

                                                                                                     
Michael D. Becker(5)..........      2002         162,142            --           13,959              200,000             108
     President and Chief            2001          96,923        20,546           34,579               11,000              60
     Executive Officer
     (since December 2002)

H. Joseph Reiser(6) ..........      2002         324,615            --               --                   --           6,911
     President and Chief            2001         314,423       100,000               --               10,000           6,412
     Executive Officer              2000         299,038        84,000          216,927               10,000           5,959
     (until December 2002)

William F. Goeckeler(7).......      2002         175,000            --               --                7,000           5,725
     Vice President of              2001         157,450        26,755               --                6,639           5,282
     Operations

Deborah Kaminsky(8)...........      2002         179,231            --               --                6,237           1,168
     Vice President of Business     2001         140,769        14,143           24,000                5,639             875
     Development

Lawrence R. Hoffman(9)........      2002         227,404            --               --                   --           5,820
     Vice President and Chief       2001         219,423        45,311               --                4,550           5,393
     Financial Officer              2000          90,673        40,000               --               55,000             129

John D. Rodwell(10)...........      2002         166,635            --               --                   --           6,000
     President and Chief            2001         194,631        26,907               --                   --           5,802
     Technical Officer of AxCell    2000         185,192        37,038               --                   --           5,471

-----------

(1)    Certain  perquisites or personal benefits are not included herein because
       they did not exceed,  in the case of each Named Executive,  the lesser of
       either  $50,000 or 10% of total annual salary and bonus  reported for the
       Named Executives.

(2)    The amounts  disclosed in this column include bonus payments made to each
       of the Named  Executives  both in cash and in shares of our common stock.
       No bonuses were paid to Named Executives for the fiscal year 2002.


                                       10


       In fiscal  year 2001,  the dollar  value of such  bonus  amounts  paid in
       shares of our common  stock were as  follows:  Mr.  Becker,  $9,199;  Dr.
       Reiser, $0; Dr. Goeckeler,  $11,978;  Ms. Kaminsky,  $6,332; Mr. Hoffman,
       $20,286; and Dr. Rodwell, $12,046. Such payments made in shares of common
       stock  were  based  upon a fair  market value of $24.40 per share of such
       common stock on the date of issuance.

       In fiscal  year 2000,  the dollar  value of such  bonus  amounts  paid in
       shares of our common stock were as follows:  Dr. Reiser, $0; Mr. Hoffman,
       $20,034; and Dr. Rodwell, $18,550. Such payments made in shares of common
       stock  were  based  upon a fair  market value of $23.44 per share of such
       common stock on the date of issuance.

(3)    The amounts disclosed in this column consist of relocation expenses.

(4)    The  amounts  disclosed in this column  include  amounts  contributed  or
       accrued  by  us  in the  respective  fiscal  years  under our  Retirement
       Savings Plan,  a defined  contribution  plan  which  consists of a 401(K)
       portion and a  discretionary  contribution  portion. In fiscal year 2002,
       these amounts were as follows:  on behalf of Mr. Becker, $0;  Dr. Reiser,
       $5,500; Dr. Goeckeler, $5,500; Ms. Kaminsky, $935;  Mr.  Hoffman, $5,500;
       and  Dr. Rodwell, $5,342.  The amounts disclosed  also include  insurance
       premiums paid by the Company with respect  to group  term life  insurance
       and with respect to fiscal year 2002.  They were  as follows:  on  behalf
       of   Mr.  Becker, $108;  Dr.  Reiser, $1,411;  Dr.  Goeckeler,  $225; Ms.
       Kaminsky, $233; Mr. Hoffman, $320; and Dr. Rodwell, $658.

(5)    Mr. Becker joined the Company in April 2001 and was promoted to President
       and Chief  Executive  Officer in December  2002. In connection  with such
       promotion,  Mr. Becker was granted options to purchase  200,000 shares of
       our common stock under our 1995 Plan,  50,000 of which remain  subject to
       availability  under the 1995 Plan option pool or stockholder  approval of
       the  increase in such  option  pool as set forth in this Proxy  Statement
       under the heading "Proposed Amendment to the 1995 Stock Option Plan." The
       exercise price per share of such options is $3.54,  the fair market value
       of our common stock on the date of grant.  50,000 of such options  vested
       immediately  upon grant,  and the remaining  150,000 options will vest in
       three equal tranches of 50,000,  based upon Mr.  Becker's  achievement of
       certain  performance  based  milestones   established  by  the  Board  of
       Directors.

(6)    Dr. Reiser resigned,  for  personal  reasons,  from his  position  as our
       President  and  Chief Executive  Officer  on  December  17,  2002. He  is
       currently a Director of the Company.

(7)    Dr. Goeckeler was promoted to Vice President, Research and Development in
       June 2001, and was promoted to Vice President, Operation in January 2003.

(8)    Ms.  Kaminsky  was promoted to Vice  President of Sales and  Marketing in
       June 2001, and assumed the responsibilities of Vice President of Business
       Development in January 2003.

(9)    Mr.  Hoffman  resigned  from his  position  as Vice  President and  Chief
       Financial Officer in December 2002.

(10)   Dr. Rodwell separated from employment with AxCell Biosciences Corporation
       in September 2002.



                                       11



Option Grants in 2002

         The following table sets forth information concerning individual grants
of stock options made during 2002 to each of the Named Executives.




                                           OPTION GRANTS IN LAST FISCAL YEAR

-----------------------------------------------------------------------------------------------------------------------
                                     Individual Grants
-------------------------------------------------------------------------------------------  --------------------------
                                                                                               Potential Realizable
                                                  Percent of                                         Value at
                                    Number of       Total                                      Assumed Annual Rates
                                   Securities      Options                                           of Stock
                                   Underlying     Granted to                                  Price Appreciation for
                                     Options      Employees     Exercise or                       Option Term (3)
                                     Granted      in Fiscal      Base Price     Expiration   --------------------------
             Name                      (#)         Year(1)      ($/share)(2)       Date         5% ($)        10%($)
              (a)                      (b)           (c)            (d)             (e)          (f)            (g)
-----------------------------------------------------------------------------------------------------------------------

                                                                                            
Michael D. Becker(4).........        150,000        59.51%           3.54        12/16/12       333,943       846,278

Michael D. Becker(4).........         50,000        19.84%           3.54        12/16/12       111,314       282,092

H. Joseph Reiser (5).........           --            --              --            --            --            --

William F. Goeckeler.........          7,000        2.78%            3.54        12/16/12        15,584        39,493

Deborah Kaminsky.............          6,237        2.47%            3.54        12/16/12        13,885        35,188

Lawrence R. Hoffman (6)......           --            --              --            --            --            --

John D. Rodwell(7)...........           --            --              --            --            --            --


-----------

(1)    Based on an aggregate  of 252,063 options  granted to employees in  2002,
       including options granted to Named Executives.

(2)    The exercise  price of all stock options  granted  during the last fiscal
       year is equal to the  average  of the  high  and low sale  prices  of our
       common stock as reported on the Nasdaq  National Market on the respective
       dates the options were  granted.  Options  granted to executive  officers
       generally  vest over three years at the rate of 33.3% per year  beginning
       on the first  anniversary of the date of grant,  subject to  acceleration
       under  certain  conditions.  Footnote  4 below  sets  forth  the  vesting
       provisions of options granted to Mr. Becker during 2002. The maximum term
       of each option granted is ten years from the date of grant.

(3)    These  amounts  represent  certain  assumed rates of  appreciation  only.
       Actual gains, if any, on stock option exercises and common stock holdings
       are dependent on the future  performance  of our common stock and overall
       stock market conditions. There is no assurance that the amounts reflected
       will be realized.

(4)    Mr. Becker joined the Company in April 2001 and was promoted to President
       and Chief  Executive  Officer in December  2002. In connection  with such
       promotion,  Mr. Becker was granted options to purchase  200,000 shares of


                                       12


       our common stock under our 1995 Plan,  50,000 of which remain  subject to
       availability  under the 1995 Plan option pool or stockholder  approval of
       the  increase in such  option  pool as set forth in this Proxy  Statement
       under the heading "Proposed Amendment to the 1995 Stock Option Plan." The
       exercise price per share of such options is $3.54,  the fair market value
       of our common stock on the date of grant.  50,000 of such options  vested
       immediately upon grant and are shown as a separate line item in the above
       table,  and the  remaining  150,000  options  will  vest in  three  equal
       tranches  of  50,000,  based  upon Mr.  Becker's  achievement  of certain
       performance based milestones established by the Board of Directors.

(5)    Dr. Reiser  resigned,  for personal  reasons,  from  his  position as our
       President  and  Chief  Executive  Officer  on  December 17, 2002.  He  is
       currently a Director of the Company.

(6)    Mr.  Hoffman  resigned  from  his position as  Vice President  and  Chief
       Financial Officer in December 2002.

(7)    Dr. Rodwell separated from employment with AxCell Biosciences Corporation
       in September 2002.


                                       13



Aggregated Option Exercises in 2002 and Year End Option Value

         The following table sets forth information  concerning each exercise of
options  during 2002 by each of the Named  Executives  and the year end value of
unexercised in-the-money options.



                                 AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                                        AND FISCAL YEAR END OPTION VALUES
-----------------------------------------------------------------------------------------------------------------------
                                                                               Number of                   Value of
                                                                         Securities Underlying           Unexercised
                                                                              Unexercised                In-the-Money
                                                                               Options at                 Options at
                                        Shares                                   Fiscal                     Fiscal
                                       Acquired                                 Year-End                 Year-End(1)
                                          on              Value                   (#)                        ($)
                                       Exercise          Realized             Exercisable/               Exercisable/
               Name                       (#)              ($)               Unexercisable              Unexercisable
                (a)                       (b)              (c)                    (d)                        (e)
-----------------------------------------------------------------------------------------------------------------------

                                                                                               
Michael D. Becker............             --               --               57,000 / 154,000               -- / --

H. Joseph Reiser(2) .........             --               --                 198,500 / --                 -- / --

William F. Goeckeler.........             --               --                7,251 / 11,875                -- / --

Deborah Kaminsky.............             --               --                3,280 / 10,596                -- / --

Lawrence R. Hoffman(3).......             --               --                 38,184 / --                  -- / --

John D. Rodwell(4)...........             --               --                   -- / --                    -- / --


----------

(1)      The  fair  market  value  of  our  common stock underlying  options  at
         December  31,  2002  was $3.01 per share, which was  below the exercise
         price of the options set forth in the table.

(2)      Dr. Reiser  resigned,  for personal  reasons,  from his position as our
         President  and  Chief  Executive Officer on  December 17, 2002.  He  is
         currently a Director of the Company.

(3)      Mr.  Hoffman  resigned  from his position  as Vice President and Chief
         Financial Officer in December 2002.

(4)      Dr.   Rodwell  separated  from  employment  with   AxCell   Biosciences
         Corporation in September  2002. Does  not include  the exercise  by Dr.
         Rodwell of options to purchase 15,000  shares of  unregistered   common
         stock  of  AxCell Biosciences Corporation in December 2002.

Employment   Contracts,   Termination   of  Employment   and   Change-in-Control
Arrangements

         On December 17, 2002, we entered into a letter  agreement  with Michael
D. Becker in  connection  with Mr.  Becker's  promotion to  President  and Chief
Executive Officer of the Company. Under the terms of such letter agreement,  Mr.
Becker shall  receive an annual base salary of $250,000  and a car  allowance of
$750 per month.  Mr. Becker shall also be eligible to participate in our Cytogen
Corporation  Performance  Bonus  Plan,  as  and if  approved  by  our  Board  of
Directors, with a target bonus rate of 30% of base salary based upon performance
objectives. Mr. Becker is also entitled to all existing Company benefits, at the
sole discretion of the Board of Directors.  In addition,  Mr. Becker was granted


                                       14


options to  purchase  200,000  shares of our common  stock  under our 1995 Plan,
50,000 of which remain subject to  availability  under the 1995 Plan option pool
or stockholder approval of the increase in such option pool as set forth in this
Proxy Statement under the heading  "Proposed  Amendment to the 1995 Stock Option
Plan." The exercise  price per share of such  options is $3.54,  the fair market
value of our common stock on the date of grant.  50,000 of such  options  vested
immediately  upon grant,  and the remaining  150,000  options will vest in three
equal  tranches  of  50,000,  based  upon Mr.  Becker's  achievement  of certain
performance based milestones established by the Board of Directors.  Pursuant to
the terms of the  letter  agreement,  in the  event we  terminate  Mr.  Becker's
employment  for reasons  other than for cause,  as defined  therein,  Mr. Becker
shall be  entitled  to  receive  twelve  month's  base pay and  continuation  of
benefits under COBRA,  and a pro rata portion of any incentive  benefits  earned
through the date of termination.

         Each of Messrs.  Becker and  Goeckeler  and Ms.  Kaminsky are currently
party to an Executive Change of Control Severance  Agreement with Cytogen.  Such
agreements provide,  generally, for the payment of twelve months' base salary, a
pro-rata portion of such officer's bonus  compensation,  the continuation of all
benefits,  reasonable  Company-paid  outplacement  assistance  and certain other
accrued rights, in the event such officer's  employment with us is terminated in
connection with a change in control as set forth therein.

Compensation Committee Interlocks And Insider Participation

         During  2002,  our   Compensation  Committee   consisted  of  Robert F.
Hendrickson, who served as Chairman and Kevin G. Lokay. There are no, and during
2002 there were no, Compensation Committee interlocks.

Interest of Certain Persons in Matters to be Acted Upon

         Mr. Becker has served as our President and Chief Executive  Officer and
as a Director of the Company  since  December 17, 2002.  Mr.  Becker  joined the
Company in April 2001 and has served in positions of  increasing  responsibility
prior to his  promotion  to President  and Chief  Executive  Officer,  including
Interim Chief Executive Officer of the Company's AxCell Biosciences  subsidiary,
Vice President, Business Development and Industry Relations, and Vice President,
Investor  Relations  Officer.  In  connection  with Mr.  Becker's  promotion  to
President  and Chief  Executive  Officer,  Mr.  Becker  was  granted  options to
purchase 200,000 shares of our Common Stock under our 1995 Plan, 50,000 of which
options  remain  subject  to  availability  under the 1995 Plan  option  pool or
stockholder  approval  of the  increase in such option pool as set forth in this
Proxy Statement under the heading  "Proposed  Amendment To The 1995 Stock Option
Plan." The exercise  price per share of such  options is $3.54,  the fair market
value of our common stock on the date of grant.  50,000 of such  options  vested
immediately  upon grant,  and the remaining  150,000  options will vest in three
equal  tranches  of  50,000,  based  upon Mr.  Becker's  achievement  of certain
performance based milestones established by the Board of Directors.


                                      15



Performance Graph

         The following graph compares the cumulative total stockholder return on
our common stock with the cumulative total return on the Nasdaq Composite Index,
the Nasdaq Pharmaceutical Index (capitalization weighted) and the Nasdaq Biotech
Index (capitalization  weighted) for a five-year period (January 1, 1998 through
December 31, 2002).

                 COMPARISON OF CUMULATIVE TOTAL RETURN(1)(2)(3)

 Among the Company, the Nasdaq Composite Index, the Nasdaq Pharmaceutical Index
                          and the Nasdaq Biotech Index
                            (Capitalization Weighted)








                            [LINE GRAPH APPEARS HERE]
                            -------------------------







                           Base Period
                           January 1,
        Company/              1998      December    December     December    December     December
       Index Name                         1998        1999        2000         2001         2002
---------------------      -----------  ---------   --------     --------    --------     --------

                                                                         
CYTO.................         $100        $51.94     $159.63      $144.25     $185.23       $20.00
NASDAQ...............         $100       $140.99     $261.48      $157.42     $124.89       $86.33
NASDAQ PHAR..........         $100       $126.94     $239.34      $298.55     $254.43      $164.36
NASDAQ BIOTECH.......         $100       $143.43     $289.21      $355.71     $298.07      $162.96


-----------

(1)  Graph  assumes $100  invested on January 1, 1998 in our common  stock,  the
     Nasdaq  Composite Index, the Nasdaq  Pharmaceutical  Index  (capitalization
     weighted) and the Nasdaq Biotech Index (capitalization weighted).  Although
     we have  previously  compared  the  Company's  performance  with the Nasdaq
     Pharmaceutical  Index,  we believe that a comparison to the Nasdaq  Biotech
     Index is now a more meaningful  presentation based upon the similarities of
     Cytogen  Corporation  to the  companies  included  in such  index.  We will
     continue to use the Nasdaq Biotech Index in future reports.

(2)  Total return assumes reinvestment of dividends.

(3)  Year ended December 31.



                                       16



Report of the Compensation Committee of the Board of Directors

Policy

         The Compensation Committee of the Board of Directors is responsible for
oversight of our executive  compensation program. The Compensation  Committee is
composed  entirely of  independent,  non-employee  directors.  The  Compensation
Committee makes  recommendations  to the full Board of Directors on compensation
policy and as to specific compensation actions,  except where independent action
by the Compensation Committee is appropriate.

         Our compensation  program,  both for our executive  officers as well as
for all  employees,  is  based  on the  philosophy  that  the  interests  of the
employees  should be closely  aligned with those of our  stockholders.  Our 2002
executive compensation program was based on the following principles:

     -    compensation  opportunities  should  attract  the best  talent  to us,
          motivate  individuals  to  perform  at their  highest  levels,  reward
          outstanding   achievement,   and  retain  the  leadership  and  skills
          necessary for building long-term stockholder value;
     -    a portion of total compensation should be at risk of performance; and
     -    individual   executives  should  be  encouraged  to  manage  from  the
          perspective of owners of the Company.

         Our 2002 compensation  program  reflected the Compensation  Committee's
assessment  as to  appropriate  treatment on an  individual  basis for the Chief
Executive  Officers  during 2002 (Mr. Becker and Dr. Reiser) and the other Named
Executives compared to the prior year levels. We target our overall compensation
program  at  the  median  level  of the  biotechnology  industry.  In  addition,
compensation  for the Named  Executives  (and other  executives),  including our
CEOs, took into account individual responsibility and performance as assessed by
the Compensation Committee.

         The  compensation  program  includes a combination of competitive  base
salary and benefits,  annual cash and stock bonus opportunities and stock option
awards. The 2002 executive  compensation program and a specific discussion as to
the compensation of the CEOs are set out below.

Annual Compensation for 2002

         Generally,   annual   compensation  of  executive  officers  under  the
executive   compensation   program  for  2002  consisted  of  salary  and  bonus
components.

Base Salary

         In  December   2001,   the   Compensation   Committee   determined  for
recommendation to the full Board of Directors,  base salaries and certain annual
incentive opportunities for 2002 for our executives,  including the CEOs and the
other Named Executives.  The Compensation  Committee generally  determines stock
awards for certain  executive  officers  under the  Company's  equity  incentive
plans.

Bonus

         A portion of 2002 executive officer annual compensation opportunity was
based  on  corporate  performance.  The  Compensation  Committee  believes  that
incentive  compensation  should be linked to  corporate  financial  results  and
corporate  goals.  Bonus  opportunity  levels for 2002  performance  were set in
advance of the year at a percentage of base salary, with the total amount of the
bonus  opportunity  dependent on the extent to which  corporate  objectives were
achieved and the amount of cash  available  as  determined  by the  Compensation
Committee.  At year-end,  the  Compensation  Committee  determined the extent to
which our financial and corporate  objectives  had been achieved and applied the
appropriate  bonus percentage to the respective base salary of each of the Named
Executives.  No bonuses were paid to any of the Named  Executives for the fiscal
year 2002.


                                       17


Long Term Compensation - Stock Options

         The  Compensation   Committee   believes  that  stock  options  are  an
appropriate   means  to  link  our  employees'   interests  with  those  of  our
stockholders.  Stock  option  awards are designed  primarily  to provide  strong
incentives for superior longer-term performance and continued retention. Because
the  Compensation  Committee  believes that corporate  performance is one of the
principal factors influencing the market value of our common stock, the granting
of stock options to our executive  officers  encourages  them to work to achieve
consistent improvements in corporate performance. Options only have value to the
recipient when the price of our common stock exceeds the exercise  price,  which
is not less than the fair market value of our common stock at the date of grant.

         Option  grants are set taking into account the  comparison of practices
at peer groups,  an  individual's  level of  responsibility  and  furtherance of
corporate objectives,  and the amount and terms of past stock option awards. The
Compensation Committee also took into account in its review of option grants the
fact that we have no other  long  term  incentive  program,  and  believes  that
options are important to retain  executives and promote steps to build long term
value.

         The  Compensation  Committee  reviews from time to time with the entire
Board of Directors  the need and  advisability  of increasing  shares  available
under any  compensation  plan and will  consider with the Board the need for the
adoption of a new stock plan to replace the 1995 Plan in future years.  Any such
change or  recommendation  would be  presented  to  stockholders  for review and
approval at a subsequent meeting of our stockholders.

Compensation of Michael D. Becker

         Mr. Becker's salary was set on the  recommendation  of the Compensation
Committee and was believed to be an appropriate  level of base  compensation  in
view of  compensation  levels  paid  by the  industry,  in view of Mr.  Becker's
experience,  and considering our continuing accomplishments under his leadership
during the year. Prior to his promotion to President and Chief Executive Officer
in December  2002, Mr.  Becker's  salary was $180,000.  Upon his promotion,  the
Compensation Committee has approved an increase of $70,000 to $250,000.  Also in
connection  with such  promotion,  Mr.  Becker was  granted  options to purchase
200,000  shares of our common stock under our 1995 Plan,  50,000 of which remain
subject to availability under the 1995 Plan option pool or stockholder  approval
of the increase in such option pool as set forth in this Proxy  Statement  under
the heading  "Proposed  Amendment to the 1995 Stock  Option  Plan." The exercise
price per share of such  options is $3.54,  the fair market  value of our common
stock on the date of  grant.  50,000 of such  options  vested  immediately  upon
grant,  and the remaining  150,000  options will vest in three equal tranches of
50,000,  based  upon Mr.  Becker's  achievement  of  certain  performance  based
milestones established by the Board of Directors.

Compensation of H. Joseph Reiser

         Dr. Reiser's salary for  2002 was  set  on  the  recommendation  of the
Compensation  Committee  and was  believed  to be an  appropriate  level of base
compensation in view of compensation levels paid by the industry, in view of Dr.
Reiser's experience,  and considering our continuing  accomplishments  under his
leadership during the year.  During 2002, Dr. Reiser's salary was $325,000.  Dr.
Reiser resigned,  for personal  reasons,  from his position as our President and
Chief Executive Officer on December 17, 2002.

Federal Income Tax Considerations

         Section  162(m)  of the  Internal  Revenue  Code of 1986,  as  amended,
generally disallows a tax deduction to public companies for certain compensation
in excess of $1 million paid to a company's Chief Executive Officer and the four
other  most  highly  compensated   executive  officers.   Certain  compensation,
including qualified performance-based  compensation,  will not be subject to the
deduction  limit if certain  requirements  are met. The  Compensation  Committee
reviews the potential effect of Section 162(m)  periodically and generally seeks
to structure  the  long-term  incentive  compensation  granted to its  executive
officers  through option issuances under the Company's equity incentive plans in
a manner that is intended to avoid  disallowance  of  deductions  under  Section
162(m).  Nevertheless,  there can be no assurance that compensation attributable
to awards granted under the Company's  equity incentive plans will be treated as
qualified performance-based  compensation under Section 162(m). In addition, the


                                       18


Compensation  Committee  reserves  the right to use its  judgment  to  authorize
compensation  payments  that may be subject  to the limit when the  Compensation
Committee  believes such payments are  appropriate  and in the best interests of
the company and its  stockholders,  after  taking  into  consideration  changing
business conditions and the performance of its employees.

         The  Compensation   Committee   believes  that  performance  should  be
rewarded,  that the  financial  interests of the  executive  officers  should be
aligned with the stockholders,  and that compensation should be competitive.  We
have structured the compensation we pay to meet these criteria.

         The  foregoing  report on  compensation  is provided  by the  following
outside directors, who constituted the Compensation Committee as of December 31,
2002.


                                         Robert F. Hendrickson, Chairman
                                         Kevin G. Lokay, Member




                                       19

         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
                         AND RELATED STOCKHOLDER MATTERS

         There were, as of March 31, 2003,  approximately  998 holders of record
and approximately  38,122 beneficial  holders of our common stock. The following
table sets forth  certain  information,  as of March 31,  2003,  with respect to
holdings  of  our  common  stock  by:  (i)  each  person  known  by us to be the
beneficial  owner of more  than 5% of the total  number of shares of our  common
stock outstanding as of such date, based upon currently  available Schedules 13D
and 13G filed  with the SEC;  (ii) each of our  directors  (which  includes  all
nominees) and Named Executives;  and (iii) all directors and executive  officers
as a group.


                                                                   Amount and Nature of
          Name and Address of Beneficial Owner(1)               Beneficial Ownership(1)(2)      Percent of Class(3)
-------------------------------------------------------         --------------------------      -------------------
                                                                                                  
(i)  Certain beneficial owners:

     The State of Wisconsin Investment Board
     121 East Wilson Street
     Madison, Wisconsin  53707.........................                  1,402,825                      16%

(ii) Directors (which includes all nominees) and Named
     Executives:

     Michael D. Becker.................................                     59,476                       *

     John E. Bagalay, Jr...............................                     17,700                       *

     Allen Bloom.......................................                          0                       *

     Stephen K. Carter.................................                      5,827                       *

     James A. Grigsby..................................                     22,925                       *

     Robert F. Hendrickson.............................                      8,880                       *

     Kevin G. Lokay....................................                      4,333                       *

     H. Joseph Reiser..................................                      3,679                       *

     William F. Goeckeler..............................                      9,118                       *

     Lawrence R. Hoffman...............................                      2,626                       *

     Deborah Kaminsky..................................                      3,735                       *

     John D. Rodwell...................................                      7,518                       *

(iii)All directors and executive officers as a
     group (9 persons).................................                    135,673                       2.0%

----------

*    Indicates amount is less than 1%.

(1)  Except  as set  forth  in the  footnotes  to  this  table  and  subject  to
     applicable  community  property law, the persons and entities named in this
     table have sole voting and investment power with respect to all shares.

(2)  Includes  shares of our common stock which the  following  persons have the
     right to acquire  upon the  exercise  of stock  options,  within 60 days of
     March 31, 2003, as follows:  Mr. Becker:  58,000; Dr. Bagalay:  15,700; Dr.
     Carter:  3,827; Mr. Grigsby:  15,480;  Mr.  Hendrickson:  5,880; Mr. Lokay:
     2,333; Dr. Reiser: 0; Dr. Goeckeler: 7,251; Mr. Hoffman:  0; Ms. Kaminsky:
     3,280; and Mr. Rodwell:  0.

(3)  Percent of class for each person and all  executive  officers and directors
     as a group is based on 8,813,832 shares of our common stock  outstanding on
     March  31,  2003  and  includes  shares  subject  to  options  held  by the
     individual or the group,  as  applicable,  which are  exercisable or become
     exercisable within 60 days following such date.

                                       20


Securities Authorized for Issuance Under Equity Compensation Plans

         The  following   table  provides   information   about  the  securities
authorized for issuance under our equity  compensation  plans as of December 31,
2002.




                                          Equity Compensation Plan Information
-------------------------------------------------------------------------------------------------------------------
                                            Number of                                    Number of securities
                                        securities to be                               remaining available for
                                           issued upon           Weighted-average       future issuance under
                                           exercise of          exercise price of         equity compensation
                                           outstanding             outstanding              plans (excluding
                                        options, warrants       options, warrants      securities reflected in
         Plan Category(1) (2)               and rights              and rights                 column (a))
                                               (a)                      (b)                       (c)(3)
-------------------------------------------------------------------------------------------------------------------

                                                                                          
(i)  Equity compensation plans                  376,106                $18.70                      18,510
     approved by security holders:
     Option Plans(4)(5)(6)..........
     Employee Stock Purchase Plan(7)              --                     --                        30,639
(ii) Equity compensation plans not
     approved by security
     holders........................            228,363                $21.58                        --
Total...............................            604,469                $19.79                      49,149


----------

(1)  Does not  include  information  related  to the  stock  option  plan of our
     subsidiary,  AxCell Biosciences  Corporation,  pursuant to which AxCell may
     issue options to purchase  shares of AxCell's common stock to employees and
     consultants of AxCell.

(2)  This table  excludes  an  aggregate  of 30,320  shares of our common  stock
     issuable under our Cytogen Retirement Savings Plan and Cytogen  Corporation
     Performance Bonus Plan with Stock Payment Program.

(3)  In addition to being  available  for future  issuance  upon the exercise of
     options that may be granted after December 31, 2002,  all shares  available
     for  issuance  under our 1999  Non-Employee  Director  Plan may  instead be
     issued  outright to eligible  directors  thereunder in payment for services
     rendered to us.

(4)  Includes information  regarding the following  stockholder-approved  equity
     compensation plans: (i) 1988 Non-Employee Director Plan; (ii) 1989 Employee
     Stock Option  Plan;  (iii) 1989 Outside  Consultant  Plan;  (iv) 1992 Stock
     Option Plan; (v) 1995 Plan; and (vi) 1999 Non-Employee Director Plan.

(5)  With respect to the 1995 Plan, this table includes the 928 shares available
     for  issuance  thereunder  prior to the Annual  Meeting,  but  excludes the
     additional  200,000  shares  that would be  available  for  issuance if the
     proposal set forth herein under the heading "Proposed Amendment To The 1995
     Stock Option Plan" to increase  the maximum  aggregate  number of shares of
     common stock  available for issuance under the 1995 Plan is approved at the
     Annual  Meeting.  In the event such  proposal is  approved,  50,000 of such
     200,000  shares will be  allocated to the December 17, 2002 option grant to
     Mr. Becker.

(6)  Included  in  such  376,106  shares  are  150,000  of  the  200,000  shares
     underlying  options granted to Mr. Becker pursuant to his December 17, 2002
     option grant. As of December 31, 2002, only 100,000 of such 200,000 options
     were available for issuance under the 1995 Plan option pool. The additional
     50,000 became  available on March 31, 2003 upon the cancellation of certain
     options outstanding under the 1995 Plan that were returned to the 1995 Plan
     option pool upon such cancellation.  The remaining 50,000 remain subject to


                                       21


     availability under the 1995 Plan option pool or stockholder approval of the
     increase in such option pool as set forth in this Proxy Statement under the
     heading "Proposed Amendment To The 1995 Stock Option Plan."

(7)  Includes  30,639 shares of common stock  issuable  under our Employee Stock
     Purchase  Plan,  under  which up to 1,900  shares of our common  stock were
     issuable in connection with the offering period which ended on December 31,
     2002.

Equity Compensation Plans Not Approved by Security Holders

         The   following   describes   the  material   features  of  our  equity
compensation  plans that have not been approved by our security holders,  as set
forth in the above table.

         In August 1998,  we issued  options to purchase  205,000  shares of our
common  stock  outside  of any of our  equity  compensation  plans to H.  Joseph
Reiser,  our President and Chief Executive  Officer from August 1998 to December
2002.  In July 2000,  we also issued  options to purchase  30,000  shares of our
common  stock  outside of any of our equity  compensation  plans to  Lawrence R.
Hoffman,  our Vice  President and Chief  Financial  Officer from July 2000 until
December  2002.  As of December  31,  2002,  an  aggregate of 40,000 of all such
options were canceled and as of the date hereof, all of such options have either
been exercised or cancelled.

         Additionally  we have issued  options to purchase  1,000  shares of our
common stock  issued  outside any of our equity  compensation  plans to Kevin G.
Lokay,  upon his  appointment  to our Board of Directors in January  2001.  Such
options have an exercise  price of $61.26 per share,  expire on January 17, 2011
and vested in full on January  17,  2002.  Such  options are subject to the same
equitable  adjustment as are our outstanding  shares of common stock and are not
afforded anti-dilution protection.

         We also issued  warrants to purchase  32,363 shares of our common stock
to various persons and entities in consideration  for services  rendered by such
persons or entities.  Such warrants have a weighted  average  exercise  price of
$28.56 per share and expire from time to time through  November  2004.  All such
warrants are immediately exercisable.

                PROPOSED AMENDMENT TO THE 1995 STOCK OPTION PLAN

The 1995 Stock Option Plan

General

         On March 28,  1995,  the Board of  Directors  approved  and, on May 23,
1995, our stockholders adopted, the 1995 Stock Option Plan, the "1995 Plan". The
1995 Plan  currently  provides for the grant of options to purchase a maximum of
450,263 shares of our common stock to eligible employees and consultants.

         The following is a summary description of the 1995 Plan as it currently
exists,  and is qualified in its entirety by the full text of the 1995 Plan. The
full text of the 1995 Plan may be obtained by our  stockholders  upon request to
the office of our Corporate Secretary.

         A Committee,  designated by our Board of Directors, the "Committee", is
authorized  to, among other things,  interpret and  administer the 1995 Plan, to
select  employees or eligible  consultants  to whom options will be granted,  to
determine the time when options will be granted and the terms and  provisions of
the options  (which may differ from one another),  and to adopt and make changes
in the rules and regulations for carrying out the 1995 Plan. The Committee shall
be  composed of not less than two outside  directors  who are also  non-employee
directors and who are not eligible to participate in the 1995 Plan.

         Our Board of Directors may amend the 1995 Plan, except that stockholder
approval is required  to: (i)  increase  the maximum  number of shares of common
stock that may be issued on  exercise  of options  granted  under the 1995 Plan,
with  certain  exceptions;  (ii) change the  categories  of persons  eligible to
receive  options;  (iii)  increase the limit on the number of shares that may be
granted  per  optionee;  or (iv)  modify the  provisions  of Section  7(a)(i) or
7(a)(ii).


                                       22

         Furthermore, our Stockholders and Board of Directors have approved, and
we have  implemented,  certain  amendments  to the 1995 Plan which  restrict our
ability,  without the approval of a majority of our stockholders,  to: (i) grant
options or stock  appreciation  rights with an exercise  price that is less than
the fair market value of the underlying  common stock; or (ii) effectively amend
or replace certain outstanding equity-based awards in a manner that would result
in lower  exercise  prices,  accelerated  vesting  schedules  or the issuance of
restricted stock. Such amendments became effective as of June 2002.

         Options  may be granted  under the 1995 Plan only to persons who at the
date of grant either:  (i) are employees or eligible  consultants;  or (ii) have
agreed to become  employees or eligible  consultants,  and, in either case,  are
determined by the Committee to be of substantial  importance to us or any of our
subsidiaries.  As of March 31, 2003,  all of our 50 employees  were  eligible to
participate  in the  1995  Plan.  Options  granted  to  persons  who are not yet
employees  or  eligible  consultants  at the date of grant may not be  exercised
until the  optionee  has become an employee or  eligible  consultant,  and shall
expire if the  optionee  fails to  commence  service as an  employee or eligible
consultant  within  six  months  (or such  other  period  as the  Committee  may
determine) after the date of grant.

         The mere grant of an option does not require any consideration from the
optionee.  The  Committee  may, in its  discretion,  provide that payment of the
exercise  price  of an  option  may be made in cash or  check.  Options  will be
exercisable  over a period to be designated by the  Committee,  but not prior to
six months or more than ten years (or five  years for  certain  incentive  stock
options)  after  the  date of  grant.  Except  as  otherwise  determined  by the
Committee,  options  granted under the 1995 Plan will be exercisable  only while
the  optionee is employed by us and within three  months  after  termination  of
employment  generally or within 12 months after  termination  of  employment  by
reason of death or disability.

         No  eligible  employee  may be granted  options to  purchase  more than
200,000 shares in any one calendar year. Under the 1995 Plan, eligible optionees
may be granted  either ISOs or NQSOs.  ISOs are intended to be "incentive  stock
options"  under Section 422 of the Code and NQSOs are those options which do not
qualify under Section 422 of the Code.  Under the Code, the exercise price of an
ISO must be at least  equal to 100% of the fair  market  value of the  shares of
common stock on the date of grant.  The aggregate fair market value  (determined
at the time an option is granted) of the common stock with respect to which ISOs
are first  exercisable  by an optionee  during any calendar  year may not exceed
$100,000.

         Options granted under the 1995 Plan are not transferable  other than by
will  or by  operation  of  the  laws  of  descent  and  distribution,  and  are
exercisable  to the extent vested at any time prior to the scheduled  expiration
date of the option. In the event of the death of an optionee,  the option may be
exercisable  by his or her  estate.  If an option  expires  or is  cancelled  or
surrendered  without being  exercised in full,  the number of shares as to which
the  option is not  exercised  will  once  again  become  shares as to which new
options may be granted. The 1995 Plan became effective as of March 28, 1995, and
will remain in effect for ten years thereafter (March 28, 2005), or until sooner
terminated by our Board of Directors.

         Unless otherwise determined by our Board of Directors,  our issuance of
shares of stock of any class, or securities  convertible into shares of stock of
any class,  for cash or  property,  or for labor or services  either upon direct
sale or upon the  exercise of rights or warrants to  subscribe  therefor,  or on
conversion of shares or obligations of the Company  convertible into such shares
or other securities, shall not affect, and no adjustment by reason thereof shall
be made with  respect to, the number,  class or price of shares of common  stock
then subject to outstanding options.

         If as a result  of:  (i) our  reorganization  or  liquidation;  or (ii)
reclassification of our capital stock, or (iii) our consolidation or merger with
or into another  corporation,  or sale of all or substantially all the assets of
ours (such  reorganization  or  liquidation or  reclassification  of our capital
stock,  or a  merger,  consolidation  or  sale  of the  type  described  in this
paragraph being a "Corporate  Transaction") while an option is outstanding,  the
holders of the common  stock become  entitled to receive,  with respect to their
common  stock,  securities or assets other than, or in addition to, their common
stock,  upon  exercise of that  option,  the holder will receive what the holder
would have owned if the holder had exercised the option  immediately  before the
Corporate  Transaction  which occurred while the option was  outstanding and had
not disposed of anything the holder would have  received as a result of that and
all subsequent Corporate Transactions.


                                       23


Federal Income Tax Treatment of the 1995 Plan

         The following generally summarizes the United States federal income tax
consequences  that generally will arise with respect to awards granted under the
1995  Plan.  This  summary  is based on the tax laws in effect as of the date of
this Proxy  Statement.  Changes to these laws could  alter the tax  consequences
described below.

         Incentive Stock Options  ("ISOs").  A participant  will not have income
upon the grant of an ISO. Also,  except as described  below, a participant  will
not have income upon exercise of an ISO if the  participant has been employed by
the Company or its corporate parent or  majority-owned  corporate  subsidiary at
all times  beginning  with the option grant date and ending three months  before
the date the participant  exercises the option.  If the participant has not been
so employed during that time,  then the  participant  will be taxed as described
below under "Nonqualified Stock Options." The exercise of an ISO may subject the
participant to the alternative minimum tax.

         A  participant  will have  income  upon the sale of the stock  acquired
under an ISO at a profit (if sales proceeds exceed the exercise price). The type
of income will depend on when the participant  sells the stock. If a participant
sells the stock more than two years  after the option was  granted and more than
one  year  after  the  option  was  exercised,  then all of the  profit  will be
long-term  capital gain.  If a  participant  sells the stock prior to satisfying
these waiting periods, then the participant will have engaged in a disqualifying
disposition  and a portion of the profit will be  ordinary  income and a portion
may be capital gain.  This capital gain will be long-term if the participant has
held the stock for more than one year and  otherwise  will be  short-term.  If a
participant sells the stock at a loss (sales proceeds are less than the exercise
price),  then the  loss  will be a  capital  loss.  This  capital  loss  will be
long-term if the participant held the stock for more than one year and otherwise
will be short-term.

         Nonqualified  Stock  Options  ("NQSOs").  A  participant  will not have
income upon the grant of a NQSO. A  participant  will have  compensation  income
upon  the  exercise  of a NQSO  equal to the  value of the  stock on the day the
participant  exercised  the option  less the  exercise  price.  Upon sale of the
stock,  the  participant  will have capital gain or loss equal to the difference
between the sales  proceeds and the value of the stock on the day the option was
exercised.  This capital gain or loss will be long-term if the  participant  has
held the stock for more than one year and otherwise will be short-term.

         Tax  Consequences to the Company.  There will be no tax consequences to
the  Company  except that the  Company  will be  entitled to a deduction  when a
participant has compensation  income.  Any such deduction will be subject to the
limitations of Section 162(m) of the Code.


                                       24

New Plan Benefits

         The following table sets forth certain  information  regarding benefits
or  amounts  that will be  received  by or  allocated  to each of the  following
individuals  under  the 1995  Plan  upon  approval  by our  stockholders  of the
amendment thereto: (i) each of the Named Executives;  (ii) all current executive
officers as a group;  (iii) all current directors who are not executive officers
as a group;  and (iv) all employees,  including all current officers who are not
executive officers, as a group:




                                             1995 Stock Option Plan


                           Name and Position                                 Number of Shares
---------------------------------------------------------------------        ----------------
                                                                                
Michael D. Becker, President and Chief Executive Officer(1)..........              50,000

All current executive officers as a group(2).........................              50,000

All current directors who are not executive officers as a group(3)...                  --

All employees, including all current officers who are not executive
   officers, as a group(4)...........................................                  --



(1)    Mr. Becker joined the Company in April 2001 and was promoted to President
       and Chief  Executive  Officer in December  2002. In connection  with such
       promotion,  Mr. Becker was granted options to purchase  200,000 shares of
       our common stock under our 1995 Plan,  50,000 of which remain  subject to
       availability  under the 1995 Plan option pool or stockholder  approval of
       the  increase in such  option  pool as set forth in this Proxy  Statement
       under the heading "Proposed Amendment to the 1995 Stock Option Plan." The
       exercise price per share of such options is $3.54,  the fair market value
       of our common stock on the date of grant.  50,000 of such options  vested
       immediately  upon grant,  and the remaining  150,000 options will vest in
       three equal tranches of 50,000,  based upon Mr.  Becker's  achievement of
       certain  performance  based  milestones   established  by  the  Board  of
       Directors.  As of the  date of  this  Proxy  Statement,  no  other  Named
       Executive has been  designated  as to receive  options from the increased
       option pool under the 1995 Plan,  if the  proposed  amendment to the 1995
       Plan is approved by stockholders.

(2)    Other than the option  grant to Mr.  Becker set forth in  Footnote 1, any
       future option grants to our executive  officers are not  determinable  at
       this time because, under the terms of the 1995 Plan, such grants are made
       in  the  discretion  of  the  Board  of  Directors  or  the  Compensation
       Committee.

(3)    Option  grants to our  directors who are  not employees are granted under
       our 1999  Non-Employee  Director  Plan,  and may not be granted under the
       1995 Plan.

(4)    Other then the  allocation  of 50,000  options to Mr. Becker set forth in
       Footnote 1, any future  option  grants to our  employees,  including  our
       current  officers,  are not determinable at this time because,  under the
       terms of the 1995 Plan,  such  grants are made in the  discretion  of the
       Board of Directors or the Compensation Committee.


                                       25

Previously Granted Options Under the 1995 Plan

         As of March 31, 2003,  we had granted  options to purchase an aggregate
of 972,921 shares of common stock (497,004 net of cancellations)  under the 1995
Plan at a weighted  average exercise price of $26.81 per share ($14.60 per share
net of cancellations).  As of March 31, 2003, 113,384 options to purchase shares
were vested and 157,652 options to purchase shares have been exercised under the
1995 Plan.  The  following  table sets forth  information  as of March 31,  2003
concerning  options  granted  under the  1995 Plan to: (i) the Named Executives;
(ii) all current executive officers as a group; (iii) all current  directors who
are not  executive officers as a group(1); (iv) each  nominee for  election as a
director(1); (v) each associate of any of such directors,  executive officers or
nominees(2)  ; (vi) each other  person who has  received  or is to receive 5% of
such options(2); and (vii) all employees, including all current officers who are
not executive officers, as a group:



                                                               Options Granted   Weighted Average
                                             Total Options         (Net of        Exercise Price     Expiration Date of
                                                Granted         Cancellation)     of Outstanding         Outstanding
                                                Through            through            Options              Options
                 Name(1)                    March 31, 2003     March 31, 2003     March 31, 2003       March 31, 2003
-------------------------------------       --------------     --------------    ---------------    --------------------
                                                                                        
(i)  The Named Executives:

       Michael D. Becker(3)...........          211,000            211,000              4.82        04/09/11 - 12/17/12
       H. Joseph Reiser(4)............           40,000              6,500             10.94              03/31/03
       William F. Goeckeler(5)........           31,847             29,497             17.78        11/28/05 - 01/14/13
       Deborah Kaminsky(6)............           13,876             13,876             22.51        12/20/10 - 12/17/12
       Lawrence R. Hoffman(7).........           29,550                 --             --                    --
       John D. Rodwell(8).............           32,200              4,000             19.53              12/15/02

(ii) All current executive officers as a
     group............................          256,723            254,373              7.29        11/28/05 - 01/14/13

(iii)All employees, including all
     current officers who are not
     executive officers, as a group...          716,198            242,631             22.27        03/31/03 - 03/24/13


----------

(1)    None.  Participation  in the 1995 Plan is  limited to our  employees  and
       eligible consultants,  therefore directors,  other than Michael D. Becker
       and H. Joseph Reiser  (prior to Dr.  Reiser's  resignation,  for personal
       reasons,  as President and Chief Executive Officer in December 2002), are
       not eligible to participate.

(2)    None.

(3)    Mr. Becker joined the Company in April 2001 and was promoted to President
       and Chief  Executive  Officer in December  2002. In connection  with such
       promotion,  Mr. Becker was granted options to purchase  200,000 shares of
       our common stock under our 1995 Plan,  50,000 of which remain  subject to
       availability  under the 1995 Plan option pool or stockholder  approval of
       the  increase in such  option  pool as set forth in this Proxy  Statement
       under the heading "Proposed Amendment to the 1995 Stock Option Plan." The
       exercise price per share of such options is $3.54,  the fair market value
       of our common stock on the date of grant.  50,000 of such options  vested
       immediately  upon grant,  and the remaining  150,000 options will vest in
       three equal tranches of 50,000,  based upon Mr.  Becker's  achievement of
       certain  performance  based  milestones   established  by  the  Board  of
       Directors.

(4)    Dr. Reiser  resigned,  for  personal reasons,  from his position  as  our
       President  and Chief  Executive  Officer on  December  17,  2002.  He  is
       currently a Director of the Company.


                                       26

(5)    Dr. Goeckeler was promoted to Vice President, Operation in January 2003.

(6)    Ms.  Kaminsky  currently  serves  as  our  Vice  President   of  Business
       Development.

(7)    Mr.  Hoffman  resigned  from  his position  as  Vice President  and Chief
       Financial Officer  December 31, 2002.

(8)    Dr. Rodwell separated from employment with AxCell Biosciences Corporation
       in September  2002. He previously served as President and Chief Technical
       Officer of AxCell Biosciences Corp.

         As of March 31, 2003,  the market value of our common stock  underlying
the 1995 Plan was $2.88 per share.

Proposed Amendment

         Stockholders  are being  asked to  consider  and vote  upon a  proposed
amendment  to the 1995 Plan to  increase  the  number of shares of common  stock
available for issuance under the 1995 Plan from 450,263 to 650,263 shares and to
reserve  an  additional  200,000  shares of our  common  stock for  issuance  in
connection with such increase.

         The  Board of  Directors  believes  that  such  amendment  provides  an
important  inducement to recruit and retain the best  available  personnel.  The
Board of Directors  believes that  providing  employees  with an  opportunity to
invest in the Company rewards them  appropriately for their efforts on behalf of
the Company.

         The  Board  of  Directors  recommends  a vote FOR the  approval  of the
Amendment to the 1995 Plan.


                   INFORMATION CONCERNING INDEPENDENT AUDITORS

         On May 20, 2002,  our Board of Directors,  upon  recommendation  of the
Audit and Finance Committee informed our independent public accountants,  Arthur
Andersen  LLP  ("Andersen"),  that they would be  dismissed  as our  independent
public  accountants,  and engaged KPMG LLP ("KPMG") to serve as our  independent
auditors for the fiscal year ending  December 31, 2002. The  appointment of KPMG
was effective immediately upon the dismissal of Andersen.

         Andersen's  prior audit report on our financial  statements for each of
the two most recent fiscal years in the period ended December 31, 2001 contained
no adverse opinion or disclaimer of opinion and was not qualified or modified as
to  uncertainty,  audit scope,  or  accounting  principles.  During our two most
recent fiscal years ended December 31, 2001,  and the subsequent  interim period
through May 20, 2002, no disagreements  between us and Andersen on any matter of
accounting principles or practices,  financial statement disclosure, or auditing
scope  or  procedure,  which  disagreements,   if  not  resolved  to  Andersen's
satisfaction, would have caused Andersen to make reference to the subject matter
of the disagreement in connection with its reports; and during such period there
were no reportable  events of the kind listed in Item 304(a)(1)(v) of Securities
and Exchange  Commission  Regulation  S-K  ("Regulation  S-K").  We have filed a
letter from Andersen  addressed to the Securities and Exchange  Commission  (the
"SEC") stating their agreement with the above statements.

         During our two most recent  fiscal years ended  December 31, 2001,  and
through May 20, 2002, we did not consult with KPMG  regarding any of the matters
or events set forth in Item 304(a)(2)(i) or (ii) of Regulation S-K.

         On May 20, 2002,  the Board,  as the Sponsor of the Cytogen  Retirement
Savings Plan (the "Retirement  Plan"), also dismissed Andersen as the Retirement
Plan's  independent  public  accountants,  and  KPMG was  appointed  independent
auditor of the Retirement Plan for the year ended December 31, 2001.

         The decision to change auditors was not the result of any  disagreement
with Andersen with respect to any reporting or disclosure requirement applicable
to the  Retirement  Plan.  The  reports of  Andersen  on the  Retirement  Plan's
financial  statements  for the fiscal years ended December 31, 2000 and 1999 did


                                       27


not contain an adverse opinion or a disclaimer of opinion and were not qualified
or modified as to uncertainty, audit scope, or accounting principles. During the
fiscal  years  ended  December  31,  2000 and 1999 and the  interim  period from
January 1, 2001 through May 24, 2002, there were no disagreements with Andersen,
in connection with the Retirement  Plan, on any matter of accounting  principles
or practices,  financial  statement  disclosure or auditing  scope and procedure
which,  if not  resolved  to the  satisfaction  of  Andersen,  would have caused
Andersen to make  reference  to the matter in their  report.  During such fiscal
years and interim  period  there were no  "reportable  events",  as that term is
defined in paragraph (a)(1)(v) of Item 304 of Regulation S-K, in connection with
the Retirement Plan.

         The  Retirement  Plan  provided  Andersen  with a copy of the foregoing
disclosures.  We have filed a letter from Andersen  addressed to the SEC stating
their agreement with the above statements applicable to the Retirement Plan.

         During  the  fiscal  years  ended  December  31,  2000 and 1999 and the
interim period through May 24, 2002, we did not consult KPMG with respect to the
application  of  accounting  principles  to  a  specified  transaction,   either
completed  or proposed,  or the type of audit  opinion that might be rendered on
the  Retirement  Plan's  financial  statements,  or  on  any  other  matters  or
reportable events listed in Item 304(a)(2)(i) and (ii) of Regulation S-K.


                      AVAILABILITY OF INDEPENDENT AUDITORS

         The Company has selected KPMG LLP as its  independent  auditors for the
year ended December 31, 2003. KPMG also served as independent auditors for 2002.
One or more representatives of KPMG is expected to attend the Annual Meeting and
have an  opportunity  to make a statement and respond to  appropriate  questions
from stockholders.


                             STOCKHOLDERS' PROPOSALS

         Stockholders who intend to have a proposal  considered for inclusion in
our proxy materials for  presentation at our 2004 Annual Meeting of Stockholders
pursuant to Rule 14a-8 under the Exchange  Act must submit their  proposal to us
at our offices at 650 College  Road East,  Suite  3100,  Princeton,  New Jersey,
08540, attention Michael D. Becker not later than January 9, 2004.

         Stockholders  who intend to present a proposal at such meeting  without
inclusion of such proposal in our proxy  materials  pursuant to Rule 14a-8 under
the Exchange Act are required to provide  advanced notice of such proposal to us
at the aforementioned address not later than March 24, 2004.

         If we do not  receive  notice of a  stockholder  proposal  within  this
timeframe,  our  management  will use its  discretionary  authority  to vote the
shares they represent,  as our Board of Directors may recommend.  We reserve the
right to  reject,  rule out of order,  or take  other  appropriate  action  with
respect to any proposal that does not comply with these and all other applicable
requirements.


                    HOUSEHOLDING OF ANNUAL MEETING MATERIALS

         Some  banks,   brokers  and  other  nominee   record   holders  may  be
participating  in the practice of  "householding"  proxy  statements  and annual
reports.  This means that only one copy of our Proxy  Statement or Annual Report
may have been sent to multiple stockholders in your household.  We will promptly
deliver  a  separate  copy of either  document  to you if you write to us at 650
College Road East, Suite 3100, Princeton,  New Jersey 08540, or call us at (609)
750-8200.  If you want to receive separate copies of the Annual Report and Proxy
Statement in the future, or if you are receiving  multiple copies and would like
to  receive  only one copy for your  household,  you should  contact  your bank,
broker,  or other  nominee  record  holder,  or you may  contact us at the above
address and phone number.


                                       28


         Our annual report to  stockholders  for the fiscal year ended  December
31, 2002,  including  financial  statements for such period,  is being mailed to
stockholders  with  this  Proxy  Statement,  but  such  annual  report  does not
constitute a part of this Proxy Statement.


                                  OTHER MATTERS

         Our Board of Directors  is not aware of any matter to be presented  for
action at the Annual Meeting other than the matters  referred to above, and does
not intend to bring any other matters  before the Annual  Meeting.  However,  if
other matters should come before the Annual  Meeting,  we intend that holders of
the proxies will vote thereon in their discretion.


                                     GENERAL

         The  accompanying  proxy is  solicited by and on behalf of our Board of
Directors,  whose notice of meeting is attached to this Proxy Statement, and the
entire cost of such solicitation will be borne by us.

         In  addition  to the use of the  mails,  proxies  may be  solicited  by
personal interview,  telephone and telegram by our directors, officers and other
employees who will not be specially compensated for these services. We will also
request  that  brokers,  nominees,  custodians  and  other  fiduciaries  forward
soliciting  materials to the beneficial  owners of shares held of record by such
brokers,  nominees,  custodians  and other  fiduciaries.  We will reimburse such
persons for their reasonable expenses in connection therewith.

         Certain  information  contained in this Proxy Statement relating to the
occupations  and security  holdings of our  directors and officers is based upon
information received from the individual directors and officers.

         WE WILL FURNISH,  WITHOUT CHARGE, A COPY OF OUR REPORT ON FORM 10-K, AS
AMENDED, FOR THE YEAR ENDED DECEMBER 31, 2002, INCLUDING  CONSOLIDATED FINANCIAL
STATEMENTS BUT NOT INCLUDING EXHIBITS,  TO EACH OF OUR STOCKHOLDERS OF RECORD ON
APRIL 28, 2003,  AND TO EACH  BENEFICIAL  STOCKHOLDER  ON THAT DATE UPON WRITTEN
REQUEST MADE TO MR. MICHAEL D. BECKER,  PRESIDENT AND CHIEF  EXECUTIVE  OFFICER,
CYTOGEN CORPORATION,  650 COLLEGE ROAD EAST, SUITE 3100,  PRINCETON,  NEW JERSEY
08540. A FEE FOR REASONABLE  EXPENSES  INCURRED IN FURNISHING SUCH EXHIBITS WILL
BE CHARGED FOR COPIES OF REQUESTED EXHIBITS.

         PLEASE  DATE,   SIGN  AND  RETURN  THE  PROXY  CARD  AT  YOUR  EARLIEST
CONVENIENCE IN THE ENCLOSED RETURN ENVELOPE.  A PROMPT RETURN OF YOUR PROXY CARD
WILL BE APPRECIATED AS IT WILL SAVE THE EXPENSE OF FURTHER MAILINGS.

                                    By Order of the Board of Directors

                                    /s/ Michael D. Becker

Princeton, New Jersey               Michael D. Becker
May 8, 2003                         President and Chief Executive Officer



                                       29

                                   APPENDIX A

                               CYTOGEN CORPORATION

                              AMENDED AND RESTATED

                             1995 STOCK OPTION PLAN

1.       Purpose; Effective Date.

         (a)     The  purposes  of this Plan are to further  the  interests  of
Cytogen  Corporation  (the  "Company")  and its  Subsidiaries  by retaining  the
services of persons now serving as officers and other employees, consultants and
advisors of the Company  and its  Subsidiaries,  attracting  and  retaining  the
services  of persons  capable of serving as  employees  and  consultants  of the
Company and its  Subsidiaries  and providing  incentives  for such employees and
consultants  to exert maximum  efforts to promote the success of the Company and
its Subsidiaries.

         (b)      The  effective date of this Plan is March 28, 1995.  This Plan
will become  effective  on that date,  subject to approval of the Plan not later
than  September  30,  1995  by a  majority  of the  votes  cast  at a duly  held
stockholders   meeting  at  which  a  quorum  representing  a  majority  of  all
outstanding voting stock is, either in person or by proxy, present and voting on
the Plan. Nothing in this Plan shall affect the rights or obligations of holders
of options granted under any other Company stock option plan.

2.       Definitions.

         Whenever used in this Plan, the following  terms will have the meanings
set forth in this paragraph:

         "Board of Directors" means the Board of Directors of the Company.

         "Code" means the U.S. Internal Revenue Code of 1986, as amended.

         "Committee" means the committee described in paragraph 3.

         "Common  Stock" means the common stock,  par value $. 01 per share,  of
the Company.

         "Date of Grant" means with respect to any Option the date the Committee
approves  the grant of the Option or such later date as may be  specified by the
Committee as the date the option will become effective.

         "Eligible Consultant" means a consultant providing services to, and who
is not an employee of, the Company or any of its Subsidiaries.

         "Employee"  means any  person  employed  by the  Company  or any of its
Subsidiaries (including, without limitation, a person employed by the Company or
any of its Subsidiaries who is also an officer or director of the Company or any
of its Subsidiaries).

         "Exercise  Price"  means with respect to any Option the price per share
which must be paid upon exercise of the Option.

         "Fair Market Value" means (i) if the Common Stock is traded in a market
in which actual  transactions are reported,  the mean of the high and low prices
at which the Common Stock is reported to have traded on the relevant date in all
markets  on which  trading in the Common  Stock is  reported,  or if there is no
reported sale of the Common Stock on the relevant  date, the mean of the highest
reported bid price and lowest  reported  asked price for the Common Stock on the
relevant date,  (ii) if the Common Stock is Publicly  Traded but only in markets
in which there is no reporting of actual  transactions,  the mean of the highest
reported bid price and the lowest  reported  asked price for the Common Stock on
the relevant  date,  or (iii) if the Common Stock is not  Publicly  Traded,  the
value of a share of Common  Stock as  determined  by the most  recent  valuation
prepared by an independent expert at the request of the Committee.



         "Incentive Stock Option" means any Option that at the time of the grant
qualifies and is  designated as an incentive  stock option within the meaning of
Section 422 of the Code.

         "Non-Employee   Director"  means  a  member  of  the  Board  who  is  a
"Non-Employee  Director"  within  the  meaning  of Rule  16b-3(b)(3)  under  the
Securities Exchange Act of 1934, as amended, or any successor provision.

         "Non-Qualified  Option" means any Option that is not an Incentive Stock
Option.

         "Option"  means any  Incentive  Stock  Option or  Non-Qualified  Option
granted under this Plan.

         "Option Agreement" means an agreement in such form as may be determined
by he  Committee,  executed  and  delivered  by the Company to the holder of any
Option with respect to that Option.

         "Outside  Director"  means a member  of the  Board who is not a current
employee of the Company (or a related  entity),  is not a former employee who is
receiving   compensation  for  prior  services  (other  than  benefits  under  a
tax-qualified  retirement  plan), was not an officer of the Company at any time,
and is not currently receiving remuneration,  either directly or indirectly,  in
any capacity  other than as a director.  An Outside  Director shall satisfy such
criteria as required under Section 162(m) of the Code.

         "Plan"  means  the  Cytogen  Corporation  1995 Stock  Option  Plan,  as
amended.

         "Publicly  Traded" means,  with respect to any class of stock, that the
class of stock is required to be registered  under Section 12 of the  Securities
Exchange  Act of 1934,  as  amended,  or that  stock of that class has been sold
within the preceding 12 months in an underwritten public offering.

         "Subsidiary"  means any corporation  that, at the time in question is a
subsidiary  corporation  of the Company  within the meaning of section 424(f) of
the Code.

         "Ten  Percent  Shareholder"  means,  with  respect  to the grant of any
Option,  a person  who at the Date of  Grant  is the  beneficial  owner of stock
possessing  more than 10% of the total  combined  voting power of all classes of
stock of the Company.

         "Termination of Service" means (a) the time when the  employee-employer
relationship between an Employee and the Company ceases to exist for any reason,
or (b) the time  when an  officer  who is not also an  Employee  ceases to be an
officer  of the  Company  for any  reason  or (c)  the  time  when  an  Eligible
Consultant  ceases to be such a consultant  for any reason,  including,  but not
limited to, a termination by resignation,  discharge, death, Total Disability or
retirement.  Any leave of absence  taken with the  consent of the  Company for a
period of not more than 90 days shall not be a  Termination  of  Service,  or if
longer,  so long as the  optionee's  right to  reemployment  with the Company is
guaranteed by statute or contract. If the period of leave exceeds 90 days and if
the  right to  reemployment  is not  guaranteed  by  statute  or  contract,  the
Termination of Service will be deemed to occur on the 91st day of the leave.

         "Total   Disability"   means  inability  of  an  Employee  or  Eligible
Consultant  to  engage  in any  substantial  gainful  activity  by  reason  of a
medically  determinable  physical or mental  impairment which can be expected to
result in death or which has lasted or can be expected to last for a  continuous
period of not less than 12 months.  All determinations as to the date and extent
of  disability  of an  Employee  or  Eligible  Consultant  will  be  made by the
Committee.

3.       Administration.

         (a)      This Plan shall be administered by a Committee, which shall be
composed  of not  less  than two  Outside  Directors  who are also  Non-Employee
Directors.  The  Committee  may,  from time to time,  adopt or rescind rules and


                                      A-2


regulations  for carrying out the provisions and purposes of this Plan.  Subject
to the express provisions of this Plan, the Committee shall have sole authority,
in  its  absolute   discretion,   to  determine  which  Employees  and  Eligible
Consultants shall receive Options,  the time when Options shall be granted,  the
terms and  provisions of the Options  (which may differ from one another) and to
do  everything  necessary or  appropriate  to administer  this Plan,  including,
without  limitation,  interpreting  the provisions of this Plan and the Options.
All  determinations  made by the  Committee  with  respect  to this Plan and the
Options shall be final, binding and conclusive.

         (b)      No  member of the  Committee  shall be  liable  for any act or
omission of the Committee or any other member of the  Committee,  or for any act
or omission on his own part, in connection with the administration of this Plan,
unless it resulted from the member's own willful misconduct.

4.       Persons Eligible to Receive Options.

         (a)      Options  may be granted under this Plan only to persons who at
the Date of Grant  either  (i) are  Employees  or  Eligible  Consultants  of the
Company or any of its  Subsidiaries  or (ii) have agreed to become  Employees or
Eligible  Consultants of the Company or any of its Subsidiaries,  and, in either
case,  are  determined by the Committee to be of  substantial  importance to the
Company or any of its Subsidiaries.

         (b)      Options  granted  to  persons  who are not  yet  Employees  or
Eligible  Consultants  at the  Date of  Grant  may not be  exercised  until  the
optionee has become an Employee or Eligible Consultant,  and shall expire if the
optionee fails to commence service as an Employee or Eligible  Consultant within
six months (or such other period as the Committee may determine)  after the Date
of Grant.

         (c)      Incentive Stock Options may be granted only to persons who are
Employees  at the Date of  Grant,  and only on such  terms  as are  provided  in
paragraphs 6, 7 and 8 hereof.

         (d)      No  Employee or  Eligible  Consultant  to whom  Options may be
granted  under this Plan may be granted  Options to purchase  more than  200,000
shares in any one calendar year.

5.       Stock Subject to the Plan.

         (a)      Subject  to any  adjustment  as provided in  paragraph  9, the
maximum  number of shares of Common  Stock as to which  Options  may be  granted
under this Plan is 450,263 shares  reduced by the number of outstanding  options
granted under the Cytogen Corporation 1989 Employee Stock Option Plan (the "1989
Plan") that are exercised  after the effective  date of this Plan. If any Option
expires or is cancelled or  surrendered  without  being  exercised in full,  the
number of shares as to which the Option is not exercised  will once again become
shares as to which new Options may be granted.  The Common Stock which is issued
on exercise of Options may be  authorized  but  unissued  shares or shares which
have been issued and reacquired by the Company.

         (b)      For   administrative   purposes  only,  the  Committee   shall
establish an account indicating the number of shares of Common Stock as to which
Options may then be granted  under this Plan (the  "Current  Account"),  and the
Committee  may issue  Options  only with  respect to the shares of Common  Stock
available  for grant as set forth in the Current  Account.  The Current  Account
shall contain the number of shares  available  for grant  calculated as follows:
(a) 450,263,  minus (b) the number of shares of Common Stock  subject to options
granted under the 1989 Plan that are exercised  after the effective date of this
Plan,  minus (c) the number of shares of Common  Stock  subject  to  outstanding
options granted under the 1989 Plan and this Plan, plus (d) the number of shares
of Common  Stock  subject to  outstanding  options  granted  under the 1989 Plan
and/or  this Plan that  expire,  are  cancelled  or  surrendered  without  being
exercised in full.

6.       Grants of Options.

         (a)      Subject  to paragraph  4(d),  the Committee will have complete
discretion to determine  when, and to which  Employees or Eligible  Consultants,
Options are to be granted, the number of shares of Common Stock to which Options
granted to each  Employee or Eligible  Consultant,  will relate,  whether and to
what extent  Options  granted to an Employee  or  Eligible  Consultant,  will be
Incentive Stock Options or Non-Qualified  Options and, subject to the provisions


                                      A-3


of  paragraphs  7 and 8, the  Exercise  Price and the term of each  Option.  The
Committee  may, in its  discretion  at the time of granting the Option,  provide
that the Exercise  Price may be paid in cash,  by the surrender of Common Stock,
by a promissory  note bearing an interest  rate not less than the market rate of
interest at such time, or by other means; subject,  however, to any requirements
of  applicable  law  which  may  limit  the  type or  amount  of  such  non-cash
consideration.  If payment by  promissory  note is  permitted:  (i) the optionee
shall be required to make a cash payment upon exercise of the Option of not less
than 20% of the Exercise  Price;  (ii) the note shall  provide for full recourse
against  the  maker;  and (iii) the note  shall be  payable in full prior to its
stated maturity upon the optionee's  Termination of Service for any reason other
than death or Total Disability.

         (b)      Any  Options  which  are not  designated  as  Incentive  Stock
Options when they are granted will be Non-Qualified Options.

         (c)      Promptly  after the Date of Grant of each Option,  the Company
shall cause an Option  Agreement to be executed  and  delivered to the holder of
the Option.  The Option Agreement shall clearly state whether the Option granted
is or is not an Incentive Stock Option. Separate Option Agreements shall be used
for Incentive Stock Options and Non-Qualified Stock Options.

         (d)      Except as otherwise  determined by the Committee,  and subject
to the requirements of applicable law, the entire Exercise Price received by the
Company upon the exercise of an option shall  constitute  stated  capital to the
extent of the  aggregate  par value of the Common Stock issued upon  exercise of
the Option.

         (e)      Any  Option granted under this Plan prior to the date the Plan
is approved by the Company's  stockholders  shall not be exercisable  unless and
until the Plan is so approved.

7.       Option Provisions.

         (a)      Exercise  Price.  No  consideration  shall be  payable  by any
optionee  for the grant of an Option.  Subject to the  provisions  of  paragraph
7(a)(i) and paragraph 8, the Exercise Price of each Option will be as determined
by the Committee.

                  (i)  The  Committee  shall not  grant  any  Option  (or  stock
         appreciation  right, if otherwise  permissible)  with an exercise price
         that is less than 100% of the Fair Market Value of the underlying stock
         on the date of grant or reduce  the  exercise  price of any  Option (or
         stock appreciation  right, if otherwise  permissible)  granted or to be
         granted under the Plan; and

                  (ii) The Committee shall not: (1) cancel and re-grant  Options
         at a lower exercise price  (including  entering into any "6 month and 1
         day"  cancellation and re-grant  scheme),  whether or not the cancelled
         Options  are put back into the  available  pool for grant;  (2) replace
         underwater  Options with restricted  stock in an exchange,  buy-back or
         other  scheme;  or (3) replace any  Options  with new Options  having a
         lower exercise price or  accelerated  vesting  schedule in an exchange,
         buy-back or other scheme.

         (b)      Term.  The term of each  Option will be as  determined  by the
Committee,  but in no event will the term of an Option be longer  than ten years
from the Date of Grant,  or five years in the case of an Incentive  Stock Option
granted to a Ten Percent  Shareholder.  Options may not be exercised  before six
months after the Date of Grant.  Options will cease to be  exercisable  prior to
the  expiration  of their  term  under  certain  circumstances  as  provided  in
paragraphs 7(f), (g), and (h).  Subject to the foregoing,  and to any vesting or
other conditions  imposed at the time it is granted,  an Option may be exercised
in whole or in part at any time, or from time to time, during its term.

         (c)      Manner  of  Exercise.   To  exercise  an  Option,  the  person
exercising the Option must deliver to the Company, at its principal office:

                  (i)  a notice of exercise, which  states  the extent to  which
         the Option is being exercised;


                                      A-4

                  (ii) a  certified  or bank  cashier's  check in an amount,  or
         Common Stock with a Fair Market Value,  equal to the Exercise  Price of
         the  Option  times  the  number  of  shares  as to  which  it is  being
         exercised,  or  consideration  in such other  form as may be  permitted
         under the terms on which the Option is granted; and

                  (iii)a  certified  or  bank  cashier's  check  equal  to any
         withholding  taxes  the  Company  is  required  to pay  because  of the
         exercise of the Option.

         The Committee may permit an Employee,  as an  alternative to making the
         payment described in clause (iii), to authorize the Company to withhold
         a sum equal to the  withholding  taxes the  Company is  required to pay
         from the Employee's salary and bonus payments over a period of not more
         than six months (or such longer period as the Company may approve). The
         date on which the  Company  receives  all the items  specified  in this
         subsection  will be the date on which the  Option is  exercised  to the
         extent described in the notice of election.

         (d)      Delivery  of Stock  Certificates.  As promptly as  practicable
after an Option is  exercised,  the  Company  will  deliver  to the  person  who
exercises  the  Option   certificates,   registered   in  that  person's   name,
representing  the number of shares of Common  Stock which were  purchased by the
exercise of the  Option.  Each  certificate  may bear a legend to  indicate,  if
applicable,  that (i) the Common Stock represented by the certificate was issued
in a transaction  which was not registered  under the Securities Act of 1933, as
amended,  and may  only  be  sold  or  transferred  in a  transaction  which  is
registered  under that Act or is exempt from the  registration  requirements  of
that Act, and (ii) the Common Stock represented by the certificate is subject to
the  obligation  of the holder to pay any unpaid  balance of the Exercise  Price
(whether  pursuant to a promissory  note or  otherwise),  and/or that the Common
Stock is pledged to secure such an obligation.

         (e)      Nontransferability  of  Options.  During the  lifetime  of the
person to whom an Option is issued,  the Option  may be  exercised  only by that
person or his or her  guardian  or legal  representative.  An Option  may not be
assigned,  pledged or hypothecated in any way, will not be subject to execution,
and will not be  transferable  otherwise than by will or the laws of descent and
distribution.  The Company will not recognize  any attempt to assign,  transfer,
pledge, hypothecate or otherwise dispose of an Option contrary to the provisions
of this Plan, or any levy of any attachment or similar  process upon any Option,
and,  except as expressly  stated in this Plan, the Company will not be required
to, and will not,  issue  Common  Stock on  exercise  of an Option to anyone who
claims to have acquired that Option from the person to whom it was granted.

         (f)      Termination  of Service of Holder of Option Other Than Because
of Total  Disability or Death.  If there is a Termination of Service of a person
to whom an Option has been granted,  other than by reason of the person's  death
or Total  Disability,  each  Option  held by the  person  may be  exercised  (if
otherwise  exercisable)  until  the  earlier  of (i) the end of the  three-month
period  immediately  following the date of the Termination of Service,  (ii) the
expiration  of the term  specified in the Option,  or (iii) such earlier time as
may be determined by the Committee at the time of granting the Option.

         (g)      Total   Disability  of  Holder  of  Option.   If  there  is  a
Termination  of Service of a person to whom an Option has been granted by reason
of his or her Total Disability,  each Option held by the person may be exercised
(if  otherwise  exercisable)  until the  earlier of (i) the end of the  one-year
period  immediately  following the date of the Termination of Service,  (ii) the
expiration  of the term  specified in the Option,  or (iii) such earlier time as
may be determined by the Committee at the time of granting the Option.

         (h)      Death  of  Holder  of  Option.  If there is a  Termination  of
Service of a person to whom an Option  has been  granted by reason of his or her
death,  or a former  Employee or Eligible  Consultant dies following the date of
his or her  Termination  of Service but at a time when an Option  still would be
exercisable by that person but for the death of the person,  each Option held by
the  person at the time of his or her death may be  exercised  by the  person or
persons  to  whom  the  Option  passed  by will or by the  laws of  descent  and
distribution  (but by no other  persons) until the earlier of (i) the end of the
one-year period immediately following the date of death (or such other period as
may be determined by the Committee at the time of granting the Option), (ii) the
expiration  of the term  specified  in the Option,  or (iii) if the death occurs
after the  Termination  of  Service,  the end of the  period in which the Option
could be exercised under paragraph 7(f) or (g).


                                      A-5

8.       Special Provisions Relating to Incentive Stock Options.

         No  Incentive  Stock Option may be granted  after March 27,  2005.  The
Exercise  Price of an  Incentive  Stock Option will be not less than 100% of the
Fair Market  Value of the Common  Stock on the Date of Grant of the  Option.  An
Incentive  Stock  Option  may not be granted  to a person  who,  at the time the
Option is granted, is a Ten Percent  Shareholder,  unless (i) the Exercise Price
of the Option is at least 110% of the Fair Market  Value of the Common  Stock on
the Date of Grant and (ii) the Option by its terms is not exercisable  after the
expiration  of five  years  from  the  Date of  Grant.  To the  extent  that the
aggregate Fair Market Value (determined at the time an Incentive Stock Option is
granted) of the Common Stock with respect to which  Incentive  Stock Options are
first  exercisable by an Employee  during any calendar year (under this Plan and
any other incentive stock option plans of the Company)  exceeds  $100,000,  such
Options shall be treated as Non-Qualified Options.

9.       Recapitalization.

         (a)      The  existence of outstanding  Options shall not affect in any
way the right or power of the Company or its  stockholders  to make or authorize
any or all adjustments,  recapitalizations,  reorganizations or other changes in
the Company's capital structure or its business,  or any merger or consolidation
of the Company, or any issue of bonds, debentures, preferred or prior preference
stock  ahead of or  affecting  the Common  Stock or the rights  thereof,  or the
dissolution or liquidation of the Company, or any sale or transfer of all or any
part of its assets or business or any other corporate act or proceeding, whether
of a similar character or otherwise.  Unless otherwise  determined by the Board,
the  issue  by the  Company  of  shares  of stock of any  class,  or  securities
convertible  into  shares of stock of any class,  for cash or  property,  or for
labor or services  either  upon  direct  sale or upon the  exercise of rights or
warrants to subscribe therefor, or on conversion of shares or obligations of the
Company convertible into such shares or other securities,  shall not affect, and
no adjustment by reason thereof shall be made with respect to, the number, class
or price of shares of Common Stock then subject to outstanding Options.

         (b)      If as a result of any (i) reorganization or liquidation of the
Company  or (ii)  reclassification  of the  Company's  capital  stock,  or (iii)
consolidation or merger of the Company with or into another corporation, or sale
of all or  substantially  all the  assets of the  Company (a  reorganization  or
liquidation of the Company or  reclassification  of the Company's capital stock,
or a merger,  consolidation  or sale of the type  described  in this  subsection
being a "Corporate Transaction") while an Option is outstanding,  the holders of
the Common Stock become  entitled to receive with respect to their Common Stock,
securities  or assets other than,  or in addition to, their Common  Stock,  upon
exercise of that Option the holder will receive what the holder would have owned
if the  holder  had  exercised  the  Option  immediately  before  the  Corporate
Transaction which occurred while the Option was outstanding and had not disposed
of  anything  the  holder  would  have  received  as a  result  of that  and all
subsequent Corporate Transactions.

10.      Rights of Option Holder.

         (a)      The  holder  of an  Option  will  not  have  any  rights  as a
stockholder  by reason of holding that Option.  Upon exercise of an Option,  the
holder  will be deemed to acquire  the  rights of a  stockholder  when,  but not
before,  the issuance of Common Stock as a result of the exercise is recorded in
the stock records of the Company.

         (b)      Nothing  in this Plan or in the grant of an Option will confer
upon any Employee the right to continue in the employment of the Company or will
interfere with or restrict in any way the rights of the Company to discharge any
Employee at any time for any reason whatsoever,  with or without cause, nor will
it impose any obligation on the Employee to remain in the employ of the Company.

11.      Laws and Regulations.

         The  obligation  of the  Company to sell and  deliver  shares of Common
Stock on exercise of Options will be subject to the condition that legal counsel
for the Company be  satisfied  that the sale and  delivery  will not violate the
Securities  Act of 1933,  as amended,  or any other  applicable  laws,  rules or
regulations.


                                      A-6


12.      Withholding of Taxes.

         (a)      In addition to the requirement in paragraph 7(c) that in order
to exercise  an Option a person must make a payment to the Company or  authorize
withholding in order to enable the Company to pay any withholding taxes due as a
result of the  exercise,  if a person who  exercised an  Incentive  Stock Option
disposes of shares of Common Stock acquired  through  exercise of that Incentive
Stock  Option  either  (i)  within  two  years  after  the  Date of Grant of the
Incentive  Stock Option or (ii) within one year after the issuance of the shares
on exercise of the Incentive  Stock  Option,  the person will notify the Company
promptly of the  occurrence of the event and, if the event was a disposition  of
Common  Stock  acquired on exercise of an  Incentive  Stock  Option,  the amount
realized upon the disposition.

         (b)      If,  whether because of a disposition of Common Stock acquired
on exercise of an Incentive Stock Option, or otherwise,  the Company is required
to pay withholding taxes to any Federal, state or other taxing authority and the
Employee  fails to  provide  the  Company  with the funds with which to pay that
withholding tax, the Company may withhold up to 50% of each payment of salary or
bonus to the  Employee  (which  will be in  addition  to any other  required  or
permitted  withholding),  until the Company has been  reimbursed  for the entire
withholding tax it was required to pay.

         (c)      The obligations contained in this paragraph 12 shall bind each
optionee,  and each optionee, by accepting and/or exercising an Option, shall be
deemed to agree to observe and comply with them.

13.      Reservation of Shares.

         The Company will at all times keep reserved for issuance on exercise of
Options a number of authorized but unissued or reacquired shares of Common Stock
equal to the  maximum  number of shares the  Company may be required to issue on
exercise of  outstanding  Options  (assuming  no  subsequent  adjustments  under
paragraph 9).

14.      Amendment of the Plan.

         The Board of Directors  may at any time and from time to time modify or
amend  this Plan in any  respect  effective  at any date the Board of  Directors
determines;  provided,  that  without the  approval of the  stockholders  of the
Company the Board of  Directors  may not, (i) except as provided in paragraph 9,
increase  the  maximum  number of shares of Common  Stock which may be issued on
exercise  of Options  granted  under this Plan;  (ii) change the  categories  of
persons  eligible to receive  Options;  (iii)  increase the  per-optionee  limit
specified in paragraph 4(d); or (iv) modify the provisions of paragraphs 7(a)(i)
or 7(a)(ii). No modification or amendment of this Plan will, without the consent
of the holder of an outstanding  Option,  adversely  affect the holder's  rights
under that Option.

15.      Interpretation

         The  Committee  shall have the power to interpret  the Plan and to make
and amend rules for putting it into effect and  administering it. It is intended
that the  Incentive  Stock  Options  granted  under  the Plan  shall  constitute
incentive  stock options within the meaning of section 422 of the Code, that the
Non-Qualified  Options shall  constitute  property subject to federal income tax
pursuant  to the  provisions  of  section 83 of the Code and that the Plan shall
qualify for the  exemption  available  under Rule 16b-3 (or any similar rule) of
the  Securities  and  Exchange   Commission.   It  is  also  intended  that  all
compensation  income  recognized  by  optionees as the result of the exercise of
Options or the disposition of Common Stock acquired on exercise of Options shall
be considered  performance-based  compensation  excludable  from such optionee's
"applicable employee remuneration" pursuant to section 162(m)(4)(C) of the Code.
The provisions of the Plan shall be interpreted  and applied insofar as possible
to carry out such intent.

16.      Termination of the Plan.

         This Plan shall  terminate on March 27, 2005 unless sooner  terminated.
The Board of Directors  may suspend or  terminate  this Plan at any time or from
time to time,  but no such  action may  adversely  affect the rights of a person
holding an outstanding Option.


                                      A-7









                                  COMMON STOCK
                               CYTOGEN CORPORATION

               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
            OF THE CORPORATION FOR THE ANNUAL MEETING OF STOCKHOLDERS

         The undersigned  hereby  constitutes and appoints Michael D. Becker and
Rita Auld,  and each of them,  his or her true and  lawful  agent and proxy with
full power of  substitution  in each,  to represent and to vote on behalf of the
undersigned all of the shares of Cytogen  Corporation  (the "Company") which the
undersigned  is entitled to vote at the Annual  Meeting of  Stockholders  of the
Company to be held at The Radisson  Hotel,  Route One at Ridge Road,  Princeton,
New  Jersey  08540 at 11:00 a.m., local time, on Tuesday, June 10, 2003, and  at
any adjournment or adjournments thereof, upon the following proposals more fully
described in the Notice of Annual Meeting of  Stockholders  and Proxy  Statement
for the Meeting (receipt of which is hereby acknowledged).

         This proxy when properly  executed will be voted in the manner directed
herein by the undersigned stockholder.  If no direction is made, this proxy will
be voted  FOR  proposals  1 and 2,  which  have  been  proposed  by our Board of
Directors.

                  (continued and to be signed on reverse side)






                 Please Detach and Mail In the Envelope Provided


    [X] Please mark your votes as indicated in this example.

1.  ELECTION OF DIRECTORS.

                                                             FOR        WITHHELD
                                                             [ ]          [ ]
                                                Nominees:

    VOTE FOR all the nominees listed;                 01   John E. Bagalay, Jr.
    except vote withheld from the following           02   Michael D. Becker
    nominee(s) (if any):                              03   Allen Bloom
                                                      04   Stephen K. Carter
                                                      05   James A. Grigsby
                                                      06   Robert F. Hendrickson
                                                      07   Kevin G. Lokay
    ----------------------------------------          08   H. Joseph Reiser

2.  APPROVAL OF PROPOSAL TO AMEND THE COMPANY'S          FOR   AGAINST   ABSTAIN
    1995 STOCK OPTION PLAN TO INCREASE THE               [ ]     [ ]       [ ]
    MAXIMUM AGGREGATE  NUMBER OF SHARES OF
    COMMON STOCK  AVAILABLE  FOR  ISSUANCE
    THEREUNDER FROM 450,263 TO 650,263 AND TO
    RESERVE AN ADDITIONAL 200,000 SHARES OF THE
    COMPANY'S  COMMON STOCK FOR ISSUANCE IN
    CONNECTION WITH SUCH INCREASE.

3.  In his or her discretion, the proxy is authorized to vote upon other
    matters as may properly come before the Meeting.

         I will   [ ]   attend the Meeting.

    PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY, USING THE
    ENCLOSED ENVELOPE.

    Signature of Common Stockholder_______________________

    Signature of Common Stockholder_______________________   Dated: ____________
                                        IF HELD JOINTLY

    Note:  This proxy must  be signed exactly as the name appears  hereon.  When
shares  are  held by  joint  tenants,  both  should  sign.  If the  signer  is a
corporation,  please sign full corporate name by duly authorized officer, giving
full title as such. If the signer is a  partnership,  please sign in partnership
name by authorized person.