SECURITIES AND EXCHANGE COMMISSION

                              Washington, DC 20549

                         -------------------------------

                                    FORM 8-K

                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

       Date of report (Date of earliest event reported): December 17, 2002
                                                         -----------------


                               CYTOGEN CORPORATION
                               -------------------
               (Exact Name of Registrant as Specified in Charter)


   Delaware                            000-14879                  222322400
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(State or Other Jurisdiction    (Commission File Number)         (IRS Employer
  of Incorporation)                                          Identification No.)


650 College Road East, 3rd Floor, Princeton, NJ                      08540
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(Address of Principal Executive Offices)                          (Zip Code)


                                 (609) 750-8200
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                         (Registrant's telephone number,
                              including area code)



       -------------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)





     ITEM 5. OTHER EVENTS AND REQUIRED FD DISCLOSURE.

     RESIGNATIONS AND APPOINTMENT OF OFFICERS

     On December 17, 2002,  Cytogen  Corporation (the "Company")  issued a press
release reporting certain  resignations and appointments  relating to its senior
management.

     On December 17, 2002, the Board of Directors accepted the resignation of H.
Joseph Reiser,  Ph. D. from the office of President and Chief Executive  Officer
of the Company, effective immediately.  Dr. Reiser has served in such capacities
since April 1998.  Dr. Reiser is leaving the Company for personal  reasons,  and
intends to continue to serve as a member of the Company's Board of Directors.

     Michael D. Becker, the Company's Vice President,  Business  Development and
Industry  Relations,  has been  unanimously  appointed by the Company's Board of
Directors  to serve,  effective  immediately,  as Dr.  Reiser's  replacement  as
President  and Chief  Executive  Officer  of the  Company.  Mr.  Becker was also
appointed to the Company's Board of Directors, effective immediately.

     On December 17, 2002,  the Board of Directors  accepted the  resignation of
Lawrence R.  Hoffman  from the position of Vice  President  and Chief  Financial
Officer of the Company,  effective  December 31, 2002. Mr. Hoffman has served in
such  capacity  since April 1998,  and has resigned  from his position  with the
Company in order to pursue other opportunities.

     In addition,  on December 17, 2002, the Company  announced the promotion of
the  Company's  Director  of  Finance,  Ms. Thu Dang,  to the  position  of Vice
President,  Finance,  effective  December 31,  2002.  Ms. Dang has been with the
Company for over fourteen years and is integrally involved in all aspects of the
Company's financial reporting process.

     Neither Dr. Reiser's  resignation as President and Chief Executive Officer,
nor Mr.  Hoffman's  resignation as Vice President and Chief  Financial  Officer,
involved  any  disagreement  with the  Company  on any  matter  relating  to the
Company's  operations,  policies or practices  and neither Dr.  Reiser,  nor Mr.
Hoffman, has requested that any matter be disclosed.

     Such press release is attached  hereto as Exhibit 99.1 and is  incorporated
herein  by  reference.  The  foregoing  description  of such  press  release  is
qualified in its entirety by reference to such document.

     ITEM 7. FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

     (c) Exhibits.

          Exhibit No.       Description
          -----------       -----------

             99.1           Press release of the Company dated December 17, 2002




                                   SIGNATURES
                                   ----------

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.


                                        CYTOGEN CORPORATION



                                        By: /s/ Michael D. Becker
                                           -------------------------------------
                                           Michael D. Becker
                                           President and Chief Executive Officer


Date:  December 17, 2002