SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                 Schedule 13G/A


   INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1 (b),
         (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (b)
                               (Amendment No. 1)*



                                TheraSense, Inc.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    883381105
--------------------------------------------------------------------------------
                                 (CUSIP Number)

                                December 31, 2004
--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

           [ ]       Rule 13d-1(b)

           [ ]       Rule 13d-1(c)

           [X]       Rule 13d-1(d)

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                         (Continued on following pages)



                               Page 1 of 18 Pages
                            Exhibit Index on Page 15



------------------------------- ------------------- ----------------------------
CUSIP NO. 883381105                    13 G                  Page 2 of 18 Pages
------------------------------- ------------------- ----------------------------

------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
               Delphi Ventures III, L.P.
               Tax ID Number:
------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP 
                                                                (a) [ ] (b) [X]
------------ -------------------------------------------------------------------
3            SEC USE ONLY
------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                      Delaware
------------------------------------ -------- ----------------------------------
             NUMBER OF
              SHARES                 5        SOLE VOTING POWER
           BENEFICIALLY                       -0-
           OWNED BY EACH
             REPORTING
              PERSON
               WITH                  -------- ----------------------------------
                                     6        SHARED VOTING POWER
                                              -0-
                                     -------- ----------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              -0-
                                     -------- ----------------------------------
                                     8        SHARED DISPOSITIVE POWER
                                              -0-
------------ -------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                          -0-
------------ -------------------------------------------------------------------

10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES                                    [ ]
------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                       0.0%
------------ -------------------------------------------------------------------
12           TYPE OF REPORTING PERSON
                                                                       PN
------------ -------------------------------------------------------------------



------------------------------- ------------------- ----------------------------
CUSIP NO. 883381105                    13 G                  Page 3 of 18 Pages
------------------------------- ------------------- ----------------------------

------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
               Delphi BioInvestments III, L.P.
               Tax ID Number:
------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                
                                                                (a) [ ] (b) [X]
------------ -------------------------------------------------------------------
3            SEC USE ONLY
------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                      Delaware
------------------------------------ -------- ----------------------------------
             NUMBER OF
              SHARES                 5        SOLE VOTING POWER
           BENEFICIALLY                       -0-
           OWNED BY EACH
             REPORTING
              PERSON
               WITH                  -------- ----------------------------------
                                     6        SHARED VOTING POWER
                                              -0-
                                     -------- ----------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              -0-
                                     -------- ----------------------------------
                                     8        SHARED DISPOSITIVE POWER
                                              -0-
------------ -------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                           -0-
------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES                                    [ ]
------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                        0.0%
------------ -------------------------------------------------------------------
12           TYPE OF REPORTING PERSON
                                                                        PN
------------ -------------------------------------------------------------------



------------------------------- ------------------- ----------------------------
CUSIP NO. 883381105                    13 G                  Page 4 of 18 Pages
------------------------------- ------------------- ----------------------------

------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
               Delphi Ventures IV, L.P.
               Tax ID Number:
------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                
                                                                (a) [ ] (b) [X]
------------ -------------------------------------------------------------------
3            SEC USE ONLY
------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                      Delaware
------------------------------------ -------- ----------------------------------
             NUMBER OF
              SHARES                 5        SOLE VOTING POWER
           BENEFICIALLY                       -0-
           OWNED BY EACH
             REPORTING
              PERSON
               WITH                  -------- ----------------------------------
                                     6        SHARED VOTING POWER
                                              -0-
                                     -------- ----------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              -0-
                                     -------- ----------------------------------
                                     8        SHARED DISPOSITIVE POWER
                                              -0-
------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                            -0-
------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES                                     [ ]
------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                         0.0%
------------ -------------------------------------------------------------------
12           TYPE OF REPORTING PERSON
                                                                         PN
------------ -------------------------------------------------------------------



------------------------------- ------------------- ----------------------------
CUSIP NO. 883381105                    13 G                  Page 5 of 18 Pages
------------------------------- ------------------- ----------------------------

------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
               Delphi BioInvestments IV, L.P.
               Tax ID Number:
------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                
                                                                (a) [ ] (b) [X]
------------ -------------------------------------------------------------------
3            SEC USE ONLY
------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                      Delaware
------------------------------------ -------- ----------------------------------
             NUMBER OF
              SHARES                 5        SOLE VOTING POWER
           BENEFICIALLY                       -0-
           OWNED BY EACH
             REPORTING
              PERSON
               WITH                  -------- ----------------------------------
                                     6        SHARED VOTING POWER
                                              -0-
                                     -------- ----------------------------------

                                     7        SOLE DISPOSITIVE POWER
                                              -0-
                                     -------- ----------------------------------

                                     8        SHARED DISPOSITIVE POWER
                                              -0-
------------ -------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                           -0-
------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES                                     [ ]
------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                        0.0%
------------ -------------------------------------------------------------------
12           TYPE OF REPORTING PERSON
                                                                        PN
------------ -------------------------------------------------------------------



------------------------------- ------------------- ----------------------------
CUSIP NO. 883381105                    13 G                  Page 6 of 18 Pages
------------------------------- ------------------- ----------------------------

------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
               Delphi Management Partners III, L.L.C.
               Tax ID Number:
------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                
                                                                (a) [ ] (b) [X]
------------ -------------------------------------------------------------------
3            SEC USE ONLY
------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                      Delaware
------------------------------------ -------- ----------------------------------
             NUMBER OF
              SHARES                 5        SOLE VOTING POWER
           BENEFICIALLY                       -0-
           OWNED BY EACH
             REPORTING
              PERSON
               WITH                  -------- ----------------------------------
                                     6        SHARED VOTING POWER
                                              -0-
                                     -------- ----------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              -0-
                                     -------- ----------------------------------
                                     8        SHARED DISPOSITIVE POWER
                                              -0-
------------ -------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                           -0-
------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES                                   [ ]
------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                        0.0%
------------ -------------------------------------------------------------------
12           TYPE OF REPORTING PERSON
                                                                        OO
------------ -------------------------------------------------------------------



------------------------------- ------------------- ----------------------------
CUSIP NO. 883381105                    13 G                  Page 7 of 18 Pages
------------------------------- ------------------- ----------------------------

------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
               Delphi Management Partners IV, L.L.C.
               Tax ID Number:
------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                
                                                                (a) [ ] (b) [X]
------------ -------------------------------------------------------------------
3            SEC USE ONLY
------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                      Delaware
------------ -------------------------------------------------------------------
             NUMBER OF
              SHARES                 5        SOLE VOTING POWER
           BENEFICIALLY                       -0-
           OWNED BY EACH
             REPORTING
              PERSON
               WITH                  -------- ----------------------------------
                                     6        SHARED VOTING POWER
                                              -0-
                                     -------- ----------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              -0-
                                     -------- ----------------------------------
                                     8        SHARED DISPOSITIVE POWER
                                              -0-
------------ -------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                           -0-
------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES                                    [ ]
------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                        0.0%
------------ -------------------------------------------------------------------
12           TYPE OF REPORTING PERSON
                                                                        OO
------------ -------------------------------------------------------------------



------------------------------- ------------------- ----------------------------
CUSIP NO. 883381105                    13 G                  Page 8 of 18 Pages
------------------------------- ------------------- ----------------------------

------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
               James J. Bochnowski
               Tax ID Number:
------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                
                                                                (a) [ ] (b) [X]
------------ -------------------------------------------------------------------
3            SEC USE ONLY
------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                                  U.S. Citizen
------------ -------------------------------------------------------------------
             NUMBER OF
              SHARES                 5        SOLE VOTING POWER
           BENEFICIALLY                       -0-
           OWNED BY EACH
             REPORTING
              PERSON
               WITH                  -------- ----------------------------------
                                     6        SHARED VOTING POWER
                                              -0-
                                     -------- ----------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              -0-
                                     -------- ----------------------------------
                                     8        -0-
------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                           -0-
------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES                                    [ ]
------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                        0.0%
------------ -------------------------------------------------------------------
12           TYPE OF REPORTING PERSON
                                                                        IN
------------ -------------------------------------------------------------------



------------------------------- ------------------- ----------------------------
CUSIP NO. 883381105                    13 G                  Page 9 of 18 Pages
------------------------------- ------------------- ----------------------------

------------ -------------------------------------------------------------------
1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
               David L. Douglass
               Tax ID Number:
------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                
                                                                (a) [ ] (b) [X]
------------ -------------------------------------------------------------------
3            SEC USE ONLY
------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
             U.S. Citizen
------------------------------------ -------- ----------------------------------
             NUMBER OF
              SHARES                 5        SOLE VOTING POWER
           BENEFICIALLY                       -0-
           OWNED BY EACH
             REPORTING
              PERSON
               WITH                  -------- ----------------------------------
                                     6        SHARED VOTING POWER
                                              -0-
                                     -------- ----------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              -0-
                                     -------- ----------------------------------
                                     8        SHARED DISPOSITIVE POWER
                                              -0-
------------ -------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                           -0-
------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES                                    [ ]
------------ -------------------------------------------------------------------

11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                        0.0%
------------ -------------------------------------------------------------------

12           TYPE OF REPORTING PERSON
                                                                        IN
------------ -------------------------------------------------------------------



------------------------------- ------------------- ----------------------------
CUSIP NO. 883381105                    13 G                  Page 10 of 18 Pages
------------------------------- ------------------- ----------------------------

------------ -------------------------------------------------------------------

1            NAME OF REPORTING
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
               Donald J. Lothrop
               Tax ID Number:
------------ -------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                
                                                                (a) [ ] (b) [X]
------------ -------------------------------------------------------------------
3            SEC USE ONLY
------------ -------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
             U.S. Citizen
------------ -------------------------------------------------------------------
             NUMBER OF
              SHARES                 5        SOLE VOTING POWER
           BENEFICIALLY                       -0-
           OWNED BY EACH
             REPORTING
              PERSON
               WITH                  -------- ----------------------------------
                                     6        SHARED VOTING POWER
                                              -0-
                                     -------- ----------------------------------
                                     7        SOLE DISPOSITIVE POWER
                                              -0-
                                     -------- ----------------------------------
                                     8        SHARED DISPOSITIVE POWER
                                              -0-
------------------------------------ -------- ----------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON                                            -0-
------------ -------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES                                      [ ]
------------ -------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                         0.0%
------------ -------------------------------------------------------------------
12           TYPE OF REPORTING PERSON
                                                                         IN
------------ -------------------------------------------------------------------



                                                             Page 11 of 18 Pages

      This statement  amends the Statement on Schedule 13G  previously  filed by
Delphi Ventures III, L.P.,  Delphi  BioInvestments  III, L.P., Delphi Management
Partners III, L.L.C.,  Delphi Ventures IV, L.P., Delphi BioInvestments IV, L.P.,
Delphi Management  Partners IV, L.L.C.,  James J. Bochnowski,  David L. Douglass
and Donald J. Lothrop.  The foregoing  entities and individuals are collectively
referred to as the  "Reporting  Persons." Only those items as to which there has
been a change are included in this Amendment No. 1.


ITEM 4.         OWNERSHIP:
                ----------

                Please see Item 5.

ITEM 5.         OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:
                ---------------------------------------------

                If this statement is being filed to report the fact that as of
                the date  hereof  the  Reporting  Person  has ceased to be the
                beneficial  owner of more  than five  percent  of the class of
                securities, check the following:   [X] Yes

ITEM 6.         OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:
                ---------------------------------------------------------------

                Please see Item 5.




                                                             Page 12 of 18 Pages


                                   SIGNATURES


         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


Dated:  February 11, 2005


                                   DELPHI VENTURES III, L.P., a Delaware 
                                   Limited Partnership


                                   By:  Delphi Management Partners III, L.L.C.,
                                        a Delaware Limited Liability Company
                                        Its General Partner



                                   By:    /s/ James J. Bochnowski               
                                          --------------------------------------
                                          James J. Bochnowski, Member


                                   DELPHI BIOINVESTMENTS III, L.P., a Delaware 
                                   Limited Partnership

                                   By:  Delphi Management Partners III, L.L.C.,
                                        a Delaware Limited Liability Company
                                        Its General Partner


                                   By:    /s/ James J. Bochnowski               
                                          --------------------------------------
                                          James J. Bochnowski, Member


                                   DELPHI MANAGEMENT PARTNERS III, L.L.C., 
                                   a Delaware Limited Liability Company


                                   By:    /s/ James J. Bochnowski               
                                          --------------------------------------
                                          James J. Bochnowski, Member



                                                             Page 13 of 18 Pages


                                   DELPHI VENTURES IV, L.P., a Delaware 
                                   Limited Partnership


                                   By:  Delphi Management Partners IV, L.L.C.,
                                        a Delaware Limited Liability Company
                                        Its General Partner



                                   By:    /s/ James J. Bochnowski               
                                          --------------------------------------
                                          James J. Bochnowski, Member


                                   DELPHI BIOINVESTMENTS IV, L.P., a Delaware 
                                   Limited Partnership

                                   By:  Delphi Management Partners IV, L.L.C.,
                                        a Delaware Limited Liability Company
                                        Its General Partner



                                   By:    /s/ James J. Bochnowski               
                                          --------------------------------------
                                          James J. Bochnowski, Member


                                   DELPHI MANAGEMENT PARTNERS IV, L.L.C., 
                                   a Delaware Limited Liability Company


                                   By:    /s/ James J. Bochnowski               
                                          --------------------------------------
                                          James J. Bochnowski,  Member



                                                             Page 14 of 18 Pages



                                   JAMES J. BOCHNOWSKI


                                   By:    /s/ James J. Bochnowski               
                                          --------------------------------------
                                          James J. Bochnowski


                                   DAVID L. DOUGLASS


                                   By:    /s/ David L. Douglass                 
                                          --------------------------------------
                                          David L. Douglass


                                   DONALD J. LOTHROP

                                   By:    /s/ David L. Douglass                 
                                          --------------------------------------
                                          David L. Douglass



                                                             Page 15 of 18 Pages


                                  EXHIBIT INDEX



                                                                 Found on
                                                               Sequentially
Exhibit                                                        Numbered Page
-------                                                        -------------
Exhibit A:  Agreement of Joint Filing                               16




                                                             Page 16 of 18 Pages


                                    EXHIBIT A



                            Agreement of Joint Filing

         The  undersigned  hereby  agree  that a  single  Schedule  13G  (or any
amendment  thereto)  relating to the Common Stock of  TheraSense,  Inc. shall be
filed on behalf of each of the  undersigned  and that  this  Agreement  shall be
filed as an exhibit to such Schedule 13G.

Date:  February 11, 2005


February 11, 2005                  DELPHI MANAGEMENT PARTNERS III, L.L.C.,
                                   a Delaware Limited Liability Company



                                   By:   /s/ James J. Bochnowski                
                                         ---------------------------------------
                                         James J. Bochnowski, Member


February 11, 2005                  DELPHI VENTURES III, L.P.,
                                   a Delaware Limited Partnership

                                   By:   Delphi Management Partners III, L.L.C.,
                                         a Delaware Limited Liability Company
                                         Its General Partner



                                   By:   /s/ James J. Bochnowski                
                                         ---------------------------------------
                                         James J. Bochnowski, Member


February 11, 2005                  DELPHI BIOINVESTMENTS III, L.P.,
                                   a Delaware Limited Partnership

                                   By:   Delphi Management Partners III, L.L.C.,
                                         a Delaware Limited Liability Company
                                         Its General Partner



                                   By:   /s/ James J. Bochnowski                
                                         ---------------------------------------
                                         James J. Bochnowski, Member



                                                             Page 17 of 18 Pages



February 11, 2005                  DELPHI MANAGEMENT PARTNERS IV, L.L.C.,
                                   a Delaware Limited Liability Company



                                   By:   /s/ James J. Bochnowski                
                                         ---------------------------------------
                                         James J. Bochnowski, Member


February 11, 2005                  DELPHI VENTURES IV, L.P.,
                                   a Delaware Limited Partnership

                                   By:   Delphi Management Partners IV, L.L.C.,
                                         a Delaware Limited Liability Company
                                         Its General Partner



                                   By:   /s/ James J. Bochnowski                
                                         ---------------------------------------
                                         James J. Bochnowski, Member


February 11, 2005                  DELPHI BIOINVESTMENTS IV, L.P.,
                                   a Delaware Limited Partnership

                                   By:   Delphi Management Partners IV, L.L.C.,
                                         a Delaware Limited Liability Company
                                         Its General Partner



                                   By:   /s/ James J. Bochnowski                
                                         ---------------------------------------
                                         James J. Bochnowski, Member



                                                             Page 18 of 18 Pages


February 11, 2005


                                      By:   /s/ James J. Bochnowski             
                                            ------------------------------------
                                            James J. Bochnowski


February 11, 2005


                                      By:   /s/ David L. Douglass               
                                            ------------------------------------
                                            David L. Douglass


February 11, 2005


                                      By:   /s/ Donald J. Lothrop               
                                            ------------------------------------
                                            Donald J. Lothrop