As filed with the Securities and Exchange Commission on June 26, 2014

Registration No. 333-     

 

 

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 


 

FORM S-1

 

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

 

KARYOPHARM THERAPEUTICS INC.

(Exact Name of Registrant as Specified in its Charter)

 

Delaware
(State or Other Jurisdiction of
Incorporation or Organization)

 

2834
(Primary Standard Industrial
Classification Code Number)

 

26-3931704
(I.R.S. Employer
Identification Number)

 

2 Mercer Road

Natick, MA 01760

(508) 975-4820

(Address, Including Zip Code, and Telephone Number, Including Area Code, of Registrant’s Principal Executive Offices)

 


 

Michael G. Kauffman, M.D., Ph.D.

Chief Executive Officer

Karyopharm Therapeutics Inc.

2 Mercer Road

Natick, MA 01760

(508) 975-4820

(Name, Address, Including Zip Code, and Telephone Number, Including Area Code, of Agent for Service)

 

Copies to:

 

Steven D. Singer, Esq.
Joshua D. Fox, Esq.
Wilmer Cutler Pickering Hale
and Dorr LLP
60 State Street
Boston, MA 02109
Telephone: (617) 526-6000

 

Christopher B. Primiano, Esq.

Vice President, General Counsel

Karyopharm Therapeutics Inc.

2 Mercer Road

Natick, MA 01760

Telephone: (508) 975-4820

 

Patrick O’Brien, Esq.
Ropes & Gray LLP
Prudential Tower
800 Boylston Street
Boston, MA 02199
Telephone: (617) 951-7000

 


 

Approximate date of commencement of proposed sale to the public: As soon as practicable after this Registration Statement becomes effective.

 

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. o

 

If this Form is filed to register additional securities for an offering pursuant Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.  x 333-196892

 

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. o

 

If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.  o

 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.  (Check one):

 

Large accelerated filer o

 

Accelerated filer o

Non-accelerated filer x (Do not check if a smaller reporting company)

 

Smaller reporting company o

 

CALCULATION OF REGISTRATION FEE

 

Title of each class of securities
to be registered

 

Amount to be
registered (1)

 

Proposed maximum
offering price
per share (2)

 

Proposed maximum
aggregate
offering price (2)

 

Amount of
registration fee

 

Common Stock, $0.0001 par value per share

 

514,334 shares

 

$

42.50

 

$

21,859,195

 

$

2,815.47

 

(1) Includes shares that the Underwriters have the option to purchase to cover over-allotments, if any.

 

(2)  Estimated in accordance with Rule 457(a) of the Securities Act of 1933 solely on the basis of $42.50, the Public Offering Price set forth on the cover page of the Registrant’s Prospectus dated June 26, 2014 relating to its initial public offering pursuant to the Company’s Registration Statement on Form S-1 (File No. 333-196892).

 

 

 



 

EXPLANATORY NOTE AND INCORPORATION BY REFERENCE

 

This registration statement is being filed with respect to the registration of additional shares of common stock, par value $0.0001 per share, of  Karyopharm Therapeutics Inc., a Delaware corporation, pursuant to Rule 462(b) under the Securities Act of 1933, as amended.  The contents of the earlier registration statement on Form S-1 (File No. 333-196892), which was declared effective by the Commission on June 26, 2014, are incorporated in this registration statement by reference.

 

The required opinions and consents are listed on an Exhibit Index attached hereto and filed herewith.

 

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SIGNATURES

 

Pursuant to the requirements of the Securities Act of 1933, the Registrant has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Natick, Commonwealth of Massachusetts, on this 26th day of June, 2014.

 

 

KARYOPHARM THERAPEUTICS INC.

 

 

 

 

 

By:

/s/ MICHAEL G. KAUFFMAN

 

 

Michael G. Kauffman, M.D., Ph.D.

 

 

Chief Executive Officer

 

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

 

 

Signature

 

Title

 

Date

 

 

 

 

 

/s/ MICHAEL G. KAUFFMAN

 

Chief Executive Officer and Director (principal

 

June 26, 2014

Michael G. Kauffman, M.D., Ph.D.

 

executive officer)

 

 

 

 

 

 

 

/s/ PAUL BRANNELLY

 

Senior Vice President, Finance and Administration

 

June 26, 2014

Paul Brannelly

 

and Treasurer (principal financial and accounting

 

 

 

 

officer)

 

 

 

 

 

 

 

*

 

Director

 

June 26, 2014

Garen G. Bohlin

 

 

 

 

 

 

 

 

 

*

 

Director

 

June 26, 2014

Barry E. Greene

 

 

 

 

 

 

 

 

 

*

 

Director

 

June 26, 2014

Deepa R. Pakianathan, Ph.D.

 

 

 

 

 

 

 

 

 

*

 

Director

 

June 26, 2014

Mansoor Raza Mirza, M.D.

 

 

 

 

 

 

 

 

 

*

 

Director

 

June 26, 2014

Kenneth E. Weg

 

 

 

 

 

 

 

 

 

*By:

/s/ PAUL BRANNELLY

 

 

 

 

 

Name: Paul Brannelly

 

 

 

 

 

Title: Attorney-in-Fact

 

 

 

 

 

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EXHIBIT INDEX

 

Exhibit No.

 

Description

5.1

 

 

Opinion of Wilmer Cutler Pickering Hale and Dorr LLP

23.1

 

 

Consent of Wilmer Cutler Pickering Hale and Dorr LLP (included in Exhibit 5.1)

23.2

 

 

Consent of McGladrey LLP

24.1

*

 

Powers of Attorney

 


* Filed as Exhibit 24.1 to the Registrant’s Registration Statement on Form S-1 (File No. 333-196892) filed with the Commission on June 19, 2014.

 

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