Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
KELSO INVESTMENT ASSOC V L P
  2. Issuer Name and Ticker or Trading Symbol
ENDO PHARMACEUTICALS HOLDINGS INC [ENDP]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
320 PARK AVENUE
3. Date of Earliest Transaction (Month/Day/Year)
10/12/2005
(Street)

NEW YORK, NY 10022
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock, par value $.01 per share (1) 10/12/2005   S   17,778,107 D $ 26.04 35,053,329 I By Endo Pharma LLC (2) (3)
Common Stock, par value $.01 per share (1) 10/12/2005   X   1,582,693 D $ 3 33,470,636 I By Endo Pharma LLC (2) (3)
Common Stock, par value $.01 per share (1) 10/12/2005   X   742,500 D $ 3.42 32,728,136 I By Endo Pharma LLC (2) (3)
Common Stock, par value $.01 per share (1) 10/12/2005   X   4,276,296 D $ 2.42 28,451,840 I By Endo Pharma LLC (2) (3)
Common Stock, par value $.01 per share (1) 10/12/2005   X   575,710 D $ 3 27,876,130 I By Endo Pharma LLC (2) (3)
Common Stock, par value $.01 per share (1) 10/12/2005   X   212,652 D $ 2.42 27,663,478 I By Endo Pharma LLC (2) (3)
Common Stock, par value $.01 per share (1) 10/12/2005   X   1,200,564 D $ 3 26,462,915 I By Endo Pharma LLC (2) (3)
Common Stock, par value $.01 per share (1) 10/12/2005   X   2,158,214 D $ 2.42 24,304,701 I By Endo Pharma LLC (2) (3)
Common Stock, par value $.01 per share (1) 10/12/2005   X   2,521,848 D $ 3 21,782,854 I By Endo Pharma LLC (2) (3)
Common Stock, par value $.01 per share (1) 10/12/2005   X   1,860,658 D $ 2.42 19,922,195 I By Endo Pharma LLC (2) (3)
Common Stock, par value $.01 per share (1) 10/12/2005   X   1,170,905 D $ 3 18,751,290 I By Endo Pharma LLC (2) (3)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Call Option (obligation to sell) $ 3 10/12/2005   X     1,582,693 10/12/2005 08/26/2007 Common Stock 1,582,693 $ 3 0 I By Endo Pharma LLC (2) (3)
Call Option (obligation to sell) $ 3.42 10/12/2005   X     742,500 10/12/2005 08/26/2007 Common Stock 742,500 $ 3.42 94,346 I By Endo Pharma LLC (2) (3)
Call Option (obligation to sell) $ 2.42 10/12/2005   X     4,276,296 10/12/2005 08/26/2007 Common Stock 4,276,296 $ 2.42 310,446 I By Endo Pharma LLC (2) (3)
Call Option (obligation to sell) $ 3 10/12/2005   X     575,710 10/12/2005 08/26/2007 Common Stock 575,710 $ 3 0 I By Endo Pharma LLC (2) (3)
Call Option (obligation to sell) $ 2.42 10/12/2005   X     212,652 10/12/2005 08/26/2007 Common Stock 212,652 $ 2.42 197,762 I By Endo Pharma LLC (2) (3)
Call Option (obligation to sell) $ 3 10/12/2005   X     1,200,564 10/12/2005 08/26/2007 Common Stock 1,200,564 $ 3 466,159 I By Endo Pharma LLC (2) (3)
Call Option (obligation to sell) $ 2.42 10/12/2005   X     2,158,214 10/12/2005 08/26/2007 Common Stock 2,158,214 $ 2.42 351,125 I By Endo Pharma LLC (2) (3)
Call Option (obligation to sell) $ 3 10/12/2005   X     2,521,848 10/12/2005 08/26/2007 Common Stock 2,521,848 $ 3 102,874 I By Endo Pharma LLC (2) (3)
Call Option (obligation to sell) $ 2.42 10/12/2005   X     1,860,658 10/12/2005 08/26/2007 Common Stock 1,860,658 $ 2.42 120,206 I By Endo Pharma LLC (2) (3)
Call Option (obligation to sell) $ 3 10/12/2005   X     1,170,905 10/12/2005 08/26/2007 Common Stock 1,170,905 $ 3 285,640 I By Endo Pharma LLC (2) (3)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
KELSO INVESTMENT ASSOC V L P
320 PARK AVENUE
NEW YORK, NY 10022
    X    

Signatures

 James J. Connors II   10/14/2005
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Kelso Investment Associates V, L.P. (KIA V") is the designated filer.
(2) KIA V may be deemed to share beneficial ownership of shares of Common Stock owned of record by Endo Pharma LLC by virtue of its status as a member of Endo Pharma LLC. KIA V shares investment and voting power along with the other members of Endo Pharma LLC with respect to secutieties owned by Endo Pharma LLC, but disclaims beneficial ownership of such securities except to the extent of its pecuniary interest.
(3) Each individual reporting person may be deemed to share beneficial ownership of shares of Common Stock owned of record by KIA V, by virtue of his status as a general partner of the general partner of KIA V, and each individual shares investment and voting power along with the other general partners of KIA V, but disclaims beneficial ownership of such securities except to the extent of his pecuniary interest.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.