SCHEDULE 13G

Amendment No. 8
ENDO PHARMACEUTICALS HLDGS INC
Common Stock
Cusip #29264F205

Cusip #29264F205
Item 1: 	   	Reporting Person - FMR LLC
Item 4: 	   	Delaware
Item 5: 	   	396,065
Item 6: 	   	0
Item 7: 	   	4,806,493
Item 8: 	   	0
Item 9: 	   	4,810,928
Item 11: 	  	4.213%
Item 12: 	  	HC

Cusip #29264F205
Item 1: 	   	Reporting Person - Edward C. Johnson 3d
Item 4: 	   	United States of America
Item 5: 	   	0
Item 6: 	   	0
Item 7: 	   	4,806,493
Item 8: 	   	0
Item 9: 	   	4,810,928
Item 11: 	  	4.213%
Item 12: 	  	IN

SCHEDULE 13G - TO BE INCLUDED IN STATEMENTS
FILED PURSUANT TO RULE 13d-1(b) or 13d-2(b)

Item 1(a). 	    	Name of Issuer:

  	  	          	ENDO PHARMACEUTICALS HLDGS INC

Item 1(b). 	    	Name of Issuer's Principal Executive Offices:

  	  	          	100 Endo Boulevard
  	  	          	Chadds Ford, Pennsylvania 19317
  	  	          	USA

Item 2(a). 	     	 Name of Person Filing:

  	   	               	 FMR LLC

Item 2(b). 	     	 Address or Principal Business Office or, if None,
Residence:

  	   	               	 245 Summer Street,Boston,Massachusetts 02210

Item 2(c). 	     	 Citizenship:

  	   	               	 Not applicable

Item 2(d). 	     	 Title of Class of Securities:

  	   	               	 Common Stock

Item 2(e). 	     	 CUSIP Number:

  	   	               	 29264F205

Item 3. 	    	This statement is filed pursuant to Rule 13d-1(b) or 13d-2(b)
and the person filing,
FMR LLC, is a parent holding company in accordance with Section 240.13d-
1(b)(ii)(G).   (Note:  See Item 7).

Item 4. 	    	Ownership

  	  	     	(a)    Amount Beneficially Owned: 	4,810,928

  	  	     	(b)    Percent of Class: 	4.213%

  	  	     	(c)    Number of shares as to which such person has:

  	  	     	       (i)    sole power to vote or to direct the vote:
396,065

  	  	     	       (ii)    shared power to vote or to direct the vote: 	0

  	  	     	       (iii)    sole power to dispose or to direct the
disposition of: 	4,806,493

  	  	     	       (iv)    shared power to dispose or to direct the
disposition of: 	0

Item 5. 	    	Ownership of Five Percent or Less of a Class.

  	    	     	If this statement is being filed to report the fact that as
of the date hereof, the reporting person has ceased to be the beneficial
owner of more than five percent of the class of securities, check the
following (X)

Item 6. 	    	Ownership of More than Five Percent on Behalf of Another
Person.

  	    	     	Not applicable.

Item 7. 	    	Identification and Classification of the Subsidiary Which
Acquired the Security Being Reported on By the Parent Holding Company.

  	    	     	See attached Exhibit A.

Item 8. 	    	Identification and Classification of Members of the Group.

  	    	     	Not applicable. See attached Exhibit A.

Item 9. 	    	Notice of Dissolution of Group.

  	    	  	Not applicable.

Item 10. 	    	Certifications.



In as much as the reporting persons are no longer the beneficial owners of
more than five percent of the number of shares outstanding, the reporting
persons have no further reporting obligation under Section 13(d) of the
Securities and Exchange Commission thereunder, and the reporting persons
have no obligation to amend this Statement if any material change occurs in
the facts set forth herein. I also certify that, to the best of my
knowledge and belief, FIL Limited and its various non-U.S. investment
management subsidiaries included on this Schedule 13G are subject to a
regulatory scheme substantially comparable to the regulatory scheme
applicable to the functionally equivalent U.S. institutions. I also
undertake to furnish to the Commission staff, upon request, information
that would otherwise be disclosed in a Schedule 13D with respect to FIL
Limited and its various non-U.S. investment management subsidiaries
included on this Schedule 13G.


Signature



After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct.

  	November 8, 2013
  	Date

  	/s/ Scott C. Goebel
  	Signature

  	Scott C. Goebel
  	 Duly authorized under Power of Attorney effective as of June 1, 2008,
by and on behalf of FMR LLC and its direct and indirect subsidiaries
SCHEDULE 13G - TO BE INCLUDED IN STATEMENTS
FILED PURSUANT TO RULE 13d-1(b) or 13d-2(b)


                Pursuant to the instructions in Item 7 of Schedule 13G,
Fidelity Management & Research Company ("Fidelity"), 245 Summer Street,
Boston, Massachusetts 02210, a wholly-owned subsidiary of FMR LLC and an
investment adviser registered under Section 203 of the Investment Advisers
Act of 1940, is the beneficial owner of 3,374,520 shares or 2.956% of the
Common Stock outstanding of ENDO PHARMACEUTICALS HLDGS INC ("the Company")
as a result of acting as investment adviser to various investment companies
registered under Section 8 of the investment Company Act of 1940.



                Edward C. Johnson 3d and FMR LLC, through its control of
Fidelity, and the funds each has sole power to dispose of the 3,374,520
shares owned by the Funds.

		Fidelity SelectCo, LLC ("SelectCo"), 1225 17th Street,
Suite 1100, Denver, Colorado 80202, a wholly-owned subsidiary of FMR LLC
and an investment adviser registered under Section 203 of the Investment
Advisers Act of 1940, is the beneficial owner of 789,543 shares or
0.690% of the outstanding Common Stock outstanding of ENDO
PHARMACEUTICALS HLDGS INC ("the Company") as a result of acting as
investment adviser to various investment companies registered under
Section 8 of the Investment Company Act of 1940 (the "SelectCo Funds").


                Edward C. Johnson 3d and FMR LLC, through its control
of SelectCo, and the SelectCo Funds each has sole power to dispose of
the 789,543 shares owned by the SelectCo Funds.




                Members of the family of Edward C. Johnson 3d, Chairman of
FMR LLC, are the predominant owners, directly or through trusts, of Series
B voting common shares of FMR LLC, representing 49% of the voting power of
FMR LLC. The Johnson family group and all other Series B shareholders have
entered into a shareholders' voting agreement under which all Series B
voting common shares will be voted in accordance with the majority vote of
Series B voting common shares. Accordingly, through their ownership of
voting common shares and the execution of the shareholders' voting
agreement, members of the Johnson family may be deemed, under the
Investment Company Act of 1940, to form a controlling group with respect to
FMR LLC.



                Neither FMR LLC nor Edward C. Johnson 3d, Chairman of FMR
LLC, has the sole power to vote or direct the voting of the shares owned
directly by the Fidelity Funds, which power resides with the Funds' Boards
of Trustees. Fidelity carries out the voting of the shares under written
guidelines established by the Funds' Boards of Trustees.



                Pyramis Global Advisors, LLC ("PGALLC"), 900 Salem Street,
Smithfield, Rhode Island, 02917, an indirect wholly-owned subsidiary of FMR
LLC and an investment adviser registered under Section 203 of the
Investment Advisers Act of 1940, is the beneficial owner of 55,680 shares
or 0.049% of the outstanding Common Stock of ENDO PHARMACEUTICALS HLDGS INC
as a result of its serving as investment adviser to institutional accounts,
non-U.S. mutual funds, or investment companies registered under Section 8
of the Investment Company Act of 1940 owning such shares.



                Edward C. Johnson 3d and FMR LLC, through its control of
PGALLC, each has sole dispositive power over 68,270 shares and sole power
to vote or to direct the voting of 55,680 shares of Common Stock owned by
the institutional accounts or funds advised by PGALLC as reported above.



                Pyramis Global Advisors Trust Company ("PGATC"), 900 Salem
Street, Smithfield, Rhode Island, 02917, an indirect wholly-owned
subsidiary of FMR LLC and a bank as defined in Section 3(a)(6) of the
Securities Exchange Act of 1934, is the beneficial owner of 357,285 shares
or 0.313 % of the outstanding Common Stock of the ENDO PHARMACEUTICALS
HLDGS INC as a result of its serving as investment manager of institutional
accounts owning such shares.



                Edward C. Johnson 3d and FMR LLC, through its control of
Pyramis Global Advisors Trust Company, each has sole dispositive power over
374,870 shares and sole power to vote or to direct the voting of 340,385
shares of Common Stock owned by the institutional accounts managed by PGATC
as reported above.



                FIL Limited ("FIL"), Pembroke Hall, 42 Crow Lane, Hamilton,
Bermuda, and various foreign-based subsidiaries provide investment advisory
and management services to a number of non-U.S. investment companies and
certain institutional investors. FIL, which is a qualified institution
under section 240.13d-1(b)(1)(ii), is the beneficial owner of 233,900
shares or 0.205% of the Common Stock outstanding of the Company.



                Partnerships controlled predominantly by members of the
family of Edward C. Johnson 3d, Chairman of FMR LLC and FIL, or trusts for
their benefit, own shares of FIL voting stock. While the percentage of
total voting power represented by these shares may fluctuate as a result of
changes in the total number of shares of FIL voting stock outstanding from
time to time, it normally represents more than 25% and less than 50% of the
total votes which may be cast by all holders of FIL voting stock. FMR LLC
and FIL are separate and independent corporate entities, and their Boards
of Directors are generally composed of different individuals.



                FMR LLC and FIL are of the view that they are not acting as
a "group" for purposes of Section 13(d) under the Securities Exchange Act
of 1934 (the "1934" Act) and that they are not otherwise required to
attribute to each other the "beneficial ownership" of securities
"beneficially owned" by the other corporation within the meaning of Rule
13d-3 promulgated under the 1934 Act. Therefore, they are of the view that
the shares held by the other corporation need not be aggregated for
purposes of Section 13(d). However, FMR LLC is making this filing on a
voluntary basis as if all of the shares are beneficially owned by FMR LLC
and FIL on a joint basis.



                FIL has sole dispositive power over 199,290 shares owned by
the International Funds. FIL has sole power to vote or direct the voting of
0 shares and no power to vote or direct the voting of 233,900 shares of
Common Stock held by the International Funds as reported above.


SCHEDULE 13G - TO BE INCLUDED IN STATEMENTS
FILED PURSUANT TO RULE 13d-1(b) or 13d-2(b)
RULE 13d-1(f)(1) AGREEMENT


                The undersigned persons, on November 8, 2013, agree and
consent to the joint filing on their behalf of this Schedule 13G in
connection with their beneficial ownership of the Common Stock of ENDO
PHARMACEUTICALS HLDGS INC at October 31, 2013.


  	FMR LLC

  	By /s/ Scott C. Goebel
  	Scott C. Goebel
  	Duly authorized under Power of Attorney effective as of June 1, 2008, by
and on behalf of FMR LLC and its direct and indirect subsidiaries

  	Edward C. Johnson 3d

  	By /s/ Scott C. Goebel
  	Scott C. Goebel
  	Duly authorized under Power of Attorney effective as of June 1, 2008, by
and on behalf of Edward C. Johnson 3d

  	Fidelity Management & Research Company

  	By /s/ Scott C. Goebel
  	Scott C. Goebel
  	Senior V.P. and General Counsel