AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON DECEMBER 11, 2001
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                      -------------------------------------

                                   SCHEDULE TO

          TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF
                       THE SECURITIES EXCHANGE ACT OF 1934
                                (AMENDMENT NO. 1)

                      -------------------------------------

                              GENOMICA CORPORATION
                       (Name of Subject Company (Issuer))

                      -------------------------------------

                                 EXELIXIS, INC.
                                       and
                         BLUEGREEN ACQUISITION SUB, INC.
                                   (Offerors)

                 (Name of Filing Persons (identifying status as
                        offeror, issuer or other person))

                    COMMON STOCK, PAR VALUE $0.001 PER SHARE
                         (Title of Class of Securities)

                                    37243Q10
                      (CUSIP Number of Class of Securities)

                            GEORGE A. SCANGOS, PH.D.
                      PRESIDENT AND CHIEF EXECUTIVE OFFICER
                                 EXELIXIS, INC.
                                 170 HARBOR WAY
                                  P.O. BOX 511
                      SOUTH SAN FRANCISCO, CALIFORNIA 94083
                                 (650) 837-7000
                 (Name, address and telephone number of persons
           authorized to receive notices and communications on behalf
                               of filing persons)


                      -------------------------------------

                                    Copy to:
                              BRUCE W. JENETT, ESQ.
                       HELLER EHRMAN WHITE & MCAULIFFE LLP
                              275 Middlefield Road
                          Menlo Park, California 94025

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[ ]    Check the box if the filing relates solely to preliminary communications
       made before the commencement of a tender offer:

       Check the appropriate boxes below to designate any transactions to which
the statement relates:

       [X]     third-party tender offer subject to Rule 14d-1.

       [ ]     issuer tender offer subject to Rule 13e-4.

       [ ]     going-private transaction subject to Rule 13e-3.

       [ ]     amendment to Schedule 13D under Rule 13d-2.

       Check the following box if the filing is a final amendment reporting the
results of the tender offer: [ ]




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        This Amendment No. 1 amends and supplements the Tender Offer Statement
on Schedule TO ("Schedule TO") filed by Exelixis, Inc., a Delaware corporation
("Exelixis"), and Bluegreen Acquisition Sub, Inc., a Delaware corporation and a
wholly owned subsidiary of Exelixis ("Merger Sub"). This Schedule TO relates to
the offer by Merger Sub to exchange a portion of a share of Exelixis common
stock, par value $0.001 per share, for each outstanding share of common stock,
par value $0.001 per share, of Genomica Corporation, a Delaware corporation
("Genomica"), other than those owned by Exelixis or its subsidiaries, based on
the exchange ratio described in the Prospectus and the related Letter of
Transmittal referenced below (which, together with any amendments or supplements
thereto, collectively constitute the "Offer").

        The Offer is made pursuant to an Agreement and Plan of Merger and
Reorganization, dated as of November 19, 2001 by and among Exelixis, Merger Sub
and Genomica. In connection with the Offer, Exelixis has filed a registration
statement with the Securities and Exchange Commission on Form S-4, as amended,
on December 11, 2001 (the "Registration Statement"). The terms and conditions of
the Offer are set forth in the prospectus (the "Prospectus"), which is part of
the Registration Statement and the related Letter of Transmittal, which are
Exhibits (a)(1) and (a)(2) to this Schedule TO.

ITEMS 1 TO 11.

        All of the information in the Prospectus and the related Letter of
Transmittal, and any prospectus supplement or other amendment thereto related to
the Offer hereafter filed with the Securities and Exchange Commission by
Exelixis and Merger Sub, is hereby incorporated by reference in answer to Items
1 through 11 of this Schedule TO.

ITEM 12. MATERIAL TO BE FILED AS EXHIBITS.

       (a)(1)  Prospectus dated December 11, 2001 (incorporated by reference
               from the Registration Statement, as amended, filed on December
               11, 2001).

       (h)(1)  Tax opinion of Heller Ehrman White & McAuliffe LLP (incorporated
               by reference from the Registration Statement, as amended, filed
               on December 11, 2001).

       (h)(2)  Tax opinion of Cooley Godward LLP (incorporated by reference from
               the Registration Statement, as amended, filed on December 11,
               2001).






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        After due inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

        Dated: December 11, 2001

                                       EXELIXIS, INC.

                                       By: /S/ GEORGE A. SCANGOS
                                           -------------------------------------
                                       Name:  George A. Scangos, Ph.D.
                                       Title: President and Chief Executive
                                              Officer

                                       BLUEGREEN ACQUISITION SUB, INC.

                                       By: /S/ GLEN Y. SATO
                                           -------------------------------------
                                       Name:  Glen Y. Sato
                                       Title: Chief Financial Officer




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                                  EXHIBIT INDEX




  EXHIBIT
  NUMBER
  ------
            
  (a)(1)       Prospectus dated December 11, 2001 (incorporated by reference
               from the Registration Statement, as amended, filed on December
               11, 2001).

  (h)(1)       Tax opinion of Heller Ehrman White & McAuliffe LLP (incorporated
               by reference from the Registration Statement, as amended, filed
               on December 11, 2001).

  (h)(2)       Tax opinion of Cooley Godward LLP (incorporated by reference from
               the Registration Statement, as amended, filed on December 11,
               2001).










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