UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D


                    Under the Securities Exchange Act of 1934
                               (Amendment No. 1)*

                            NEOSE TECHNOLOGIES, INC.
                            ------------------------
                                (Name of Issuer)

                    Common Stock, Par Value $0.01 Per Share
                    ---------------------------------------
                         (Title of Class of Securities)

                                   640522108
                                   ---------
                                 (CUSIP Number)

                               James E. Kaye, Esq.
                       Akin Gump Strauss Hauer & Feld LLP
                               590 Madison Avenue
                            New York, New York 10022
                                 (212) 872-1000
                                 --------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                  May 17, 2004
                                  ------------
                      (Date of Event which Requires Filing
                               of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of ss.ss.240.13d-1(e),  240.13d-1(f) or 240.13d-1(g), check the
following box [ ].

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the  schedule,  including  all exhibits.  See  ss.240.13d-7  for other
parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                          Continued on following pages
                               Page 1 of 13 Pages
                             Exhibit Index: Page 13



                                  SCHEDULE 13D

CUSIP No. 640522108                                           Page 2 of 13 Pages


1        Names of Reporting Persons
         I.R.S. Identification Nos. of above persons (entities only).

                  MHR CAPITAL PARTNERS LP

2        Check the Appropriate Box if a Member of a Group (See Instructions)
                                               a. [ ]
                                               b. [X]

3        SEC Use Only

4        Source of Funds (See Instructions)

                  WC

5        Check if Disclosure of Legal Proceedings Is Required Pursuant to Items
         2(d) or 2(e)

                  [ ]

6        Citizenship or Place of Organization

                  Delaware

                           7        Sole Voting Power
 Number of                                  949,078
    Shares

Beneficially               8        Shared Voting Power
 Owned By                                   0
    Each
 Reporting                 9        Sole Dispositive Power
   Person                                   949,078
    With
                           10       Shared Dispositive Power
                                            0

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                  949,078

12       Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
         Instructions)

                  [X]

13       Percent of Class Represented By Amount in Row (11)

                  4.8%

14       Type of Reporting Person (See Instructions)

                  PN





                                  SCHEDULE 13D

CUSIP No. 640522108                                           Page 3 of 13 Pages


1        Names of Reporting Persons
         I.R.S. Identification Nos. of above persons (entities only).

                  MRL PARTNERS LP

2        Check the Appropriate Box if a Member of a Group (See Instructions)
                                               a. [ ]
                                               b. [X]

3        SEC Use Only

4        Source of Funds (See Instructions)

                  AF

5        Check if Disclosure of Legal Proceedings Is Required Pursuant to Items
         2(d) or 2(e)

                  [ ]

6        Citizenship or Place of Organization

                  Delaware

                           7        Sole Voting Power
 Number of                                  502,759
    Shares

Beneficially               8        Shared Voting Power
 Owned By                                   0
    Each
 Reporting                 9        Sole Dispositive Power
   Person                                   502,759
    With
                           10       Shared Dispositive Power
                                            0

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                  502,759

12       Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
         Instructions)

                  [X]

13       Percent of Class Represented By Amount in Row (11)

                  2.5%

14       Type of Reporting Person (See Instructions)

                  PN





                                  SCHEDULE 13D

CUSIP No. 640522108                                           Page 4 of 13 Pages


1        Names of Reporting Persons
         I.R.S. Identification Nos. of above persons (entities only).

                  OTT LLC

2        Check the Appropriate Box if a Member of a Group (See Instructions)
                                               a. [ ]
                                               b. [X]

3        SEC Use Only

4        Source of Funds (See Instructions)

                  Not Applicable

5        Check if Disclosure of Legal Proceedings Is Required Pursuant to Items
         2(d) or 2(e)

                  [ ]

6        Citizenship or Place of Organization

                  Delaware

                           7        Sole Voting Power
 Number of                                  42,105
    Shares

Beneficially               8        Shared Voting Power
 Owned By                                   0
    Each
 Reporting                 9        Sole Dispositive Power
   Person                                   42,105
    With
                           10       Shared Dispositive Power
                                            0

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                  42,105

12       Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
         Instructions)

                  [X]

13       Percent of Class Represented By Amount in Row (11)

                  0.2%

14       Type of Reporting Person (See Instructions)

                  OO





                                  SCHEDULE 13D

CUSIP No. 640522108                                           Page 5 of 13 Pages


1        Names of Reporting Persons
         I.R.S. Identification Nos. of above persons (entities only).

                  MHR ADVISORS LLC

2        Check the Appropriate Box if a Member of a Group (See Instructions)
                                               a. [ ]
                                               b. [X]

3        SEC Use Only

4        Source of Funds (See Instructions)

                  Not Applicable

5        Check if Disclosure of Legal Proceedings Is Required Pursuant to Items
         2(d) or 2(e)

                  [ ]

6        Citizenship or Place of Organization

                  Delaware

                           7        Sole Voting Power
 Number of                                  0
    Shares

Beneficially               8        Shared Voting Power
 Owned By                                   1,451,837
    Each
 Reporting                 9        Sole Dispositive Power
   Person                                   0
    With
                           10       Shared Dispositive Power
                                            1,451,837

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                  1,451,837

12       Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
         Instructions)

                  [X]

13       Percent of Class Represented By Amount in Row (11)

                  7.3%

14       Type of Reporting Person (See Instructions)

                  OO





                                  SCHEDULE 13D

CUSIP No. 640522108                                           Page 6 of 13 Pages


1        Names of Reporting Persons
         I.R.S. Identification Nos. of above persons (entities only).

                  MARK H. RACHESKY, M.D.

2        Check the Appropriate Box if a Member of a Group (See Instructions)
                                               a. [ ]
                                               b. [X]

3        SEC Use Only

4        Source of Funds (See Instructions)

                  Not Applicable

5        Check if Disclosure of Legal Proceedings Is Required Pursuant to Items
         2(d) or 2(e)

                  [ ]

6        Citizenship or Place of Organization

                  United States of America

                           7        Sole Voting Power
 Number of                                  1,566,671
    Shares

Beneficially               8        Shared Voting Power
 Owned By                                   0
    Each
 Reporting                 9        Sole Dispositive Power
   Person                                   1,566,671
    With
                           10       Shared Dispositive Power
                                            0

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                  1,566,671

12       Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
         Instructions)

                  [ ]

13       Percent of Class Represented By Amount in Row (11)

                  7.8%

14       Type of Reporting Person (See Instructions)

                  IN; HC




                                                              Page 7 of 13 Pages


                  This  Amendment  No. 1 to  Schedule  13D relates to the Common
Stock, par value $0.01 per share (the "Shares") of Neose Technologies, Inc. (the
"Issuer").  This Amendment No. 1 supplementally  amends the initial statement on
Schedule  13D,  dated  July 9,  1999  (the  "Initial  Statement"),  filed by the
Reporting  Persons (as defined  herein).  This Amendment No. 1 is being filed by
the Reporting Persons to report the number of Shares which the Reporting Persons
may be deemed to beneficially  own has increased by more than one percent of the
current amount of  outstanding  Shares.  Capitalized  terms used but not defined
herein shall have the meanings  ascribed to them in the Initial  Statement.  The
Initial Statement is supplementally amended as follows.

Item 2.           Identity and Background

                  This  Statement  is  being  filed  on  behalf  of  each of the
following persons (collectively, the "Reporting Persons"):

                  (i) MHR Capital Partners LP ("MHR");

                  (ii) MRL Partners LP ("MRL");

                  (iii) OTT LLC ("OTT");

                  (iv) MHR Advisors LLC ("Advisors"); and

                  (v) Mark H. Rachesky, M.D. ("Dr. Rachesky")

                  This Statement  relates to the Shares held for the accounts of
MHR, MRL, OTT and Dr. Rachesky.  The general partner of MHR and MRL is Advisors.
Dr.  Rachesky is the Managing  Member of Advisors and OTT and, in such capacity,
may be deemed to having voting and  dispositive  power over the Shares and other
securities held for the accounts of MHR, MRL and OTT.

Item 3.           Source and Amount of Funds or Other Consideration

                  MHR expended  approximately  $4,999,997 of its working capital
to purchase the securities  reported  herein as having been acquired since March
20, 2004 (60 days prior to the date hereof), as set forth in Annex A herein.

                  The securities  held for the accounts of MHR, MRL, OTT and Dr.
Rachesky may be held through  margin  accounts  maintained  with brokers,  which
extend margin  credit as and when  required to open or carry  positions in their
margin  accounts,  subject  to  applicable  federal  margin  regulations,  stock
exchange rules and such firms' credit policies.  The positions which may be held
in the margin  accounts,  including  the  Shares,  may be pledged as  collateral
security for the repayment of debit balances in the respective accounts.

Item 4.           Purpose of Transaction

                  Dr.  Rachesky  serves on the board of directors of the Issuer.
As a director of the Issuer,  Dr. Rachesky may have influence over the corporate
activities  of the  Issuer,  including  activities  which  may  relate  to items
described in subparagraphs (a) through (j) of Item 4 of Schedule 13D.

                                                              Page 8 of 13 Pages


                  The Reporting  Persons reserve the right to acquire,  or cause
to be acquired,  additional securities of the Issuer, to dispose of, or cause to
be disposed,  such securities at any time or to formulate other purposes,  plans
or proposals regarding the Issuer or any of its securities, to the extent deemed
advisable in light of general  investment and trading  policies of the Reporting
Persons, market conditions or other factors.

Item 5.           Interest in Securities of the Issuer

                  According  to  information  provided  by  the  Issuer  to  the
Reporting Persons, there were 19,968,437 Shares outstanding as of May 18, 2004.

                  (a) (i) MHR may be  deemed  the  beneficial  owner of  949,078
Shares  (approximately  4.8% of the total  number of Shares  outstanding).  This
number consists of 949,078 Shares held for its account.

                      (ii) MRL may  be  deemed  the beneficial  owner of 502,759
Shares  (approximately  2.5%  of  the  total number of Shares outstanding). This
number consists of 502,759 Shares held for its account.

                      (iii) OTT  may  be  deemed the beneficial owner of  42,105
Shares  (approximately  0.2%  of  the  total number of Shares outstanding). This
number consists of 42,105 Shares held for its account.

                      (iv) Advisors  may  be  deemed  the  beneficial  owner  of
1,451,837 Shares (approximately 7.3% of the total number of Shares outstanding).
This  number  consists  of A) 949,078 Shares held  for  the  account of MHR, and
B) 502,759 Shares held for the account of MRL.

                      (v)  Dr.  Rachesky  may  be  deemed  the  beneficial owner
of  1,566,671  Shares  (approximately  7.8%  of  the  total  number  of   Shares
outstanding assuming the exercise of all presently-exercisable  options held for
Dr. Rachesky's account). This number consists of A) 949,078  Shares held for the
account of MHR, B) 502,759 Shares held for the account of  MRL, C) 42,105 Shares
held for the account of OTT, and D) 72,729 Shares issuable  upon the exercise of
all options held for the account of Dr. Rachesky.

                  (b) (i) MHR may be deemed to have the sole power to direct the
voting  and  disposition  of  the  949,078  Shares  which  may be  deemed  to be
beneficially owned by MHR as described above.

                      (ii) MRL may be deemed  to  have the sole power to  direct
the voting  and  disposition  of  the  502,759  Shares which may be deemed to be
beneficially owned by MRL as described above.

                      (iii) OTT may be deemed to  have the sole power to  direct
the  voting  and  disposition  of  the  42,105  Shares which may be deemed to be
beneficially owned by OTT as described above.

                      (iv) Advisors may be deemed to have shared power to direct
the voting  and  disposition  of  the 1,451,837 Shares which may be deemed to be
beneficially owned by MHR and MRL as described above.

                      (iii) Dr. Rachesky may be deemed to have the sole power to
direct the voting and disposition of the 1,566,671 Shares which may be deemed to
be beneficially owned by MHR, MRL, OTT and Dr. Rachesky as described above.

                                                              Page 9 of 13 Pages


                  (c) Except for the transactions  listed on Annex A hereto, all
of which  were  effected  in a private  transaction  with the  Issuer on May 17,
2004,  there  have been no  transactions  with respect to the Shares since March
20, 2004 (60 days prior to the date hereof) by any of the Reporting Persons.

                  (d) (i) The  partners  of MHR,  including  Advisors,  have the
right to participate in the receipt of dividends from, or proceeds from the sale
of,  the  securities  held  for the  account  of MHR in  accordance  with  their
partnership interests in MHR.

                      (ii) The  partners  of  MRL,  including Advisors, have the
right to participate in the receipt of dividends from, or proceeds from the sale
of, the  securities  held  for  the  account  of  MRL  in  accordance with their
partnership interests in MRL.

                      (iii) The members of OTT have the right to participate  in
the receipt of dividends from, or proceeds from the sale of, the securities held
for the account of OTT in accordance with their membership interests in OTT.

                  (e) As of the date hereof,  each of MHR, MRL and OTT ceased to
be the beneficial owners of more than five percent of the Shares.

Item 6.           Contracts, Arrangements, Understandings or Relationships  with
                  Respect to Securities of the Issuer.

                  On May  17,  2004,  the  Issuer  entered  into a  subscription
agreement (the "Subscription Agreement") with MHR (the form of such agreement is
attached hereto as Exhibit 7.3 and incorporated  herein by reference in response
to this Item 6). Pursuant to the Subscription  Agreement,  MHR purchased 738,552
Shares for a purchase price of $6.77. The offering and sale of the Shares by the
Issuer were made pursuant to a Registration  Statement on Form S-3 (Registration
No. 333-106327).

                  From  time to time  each of the  Reporting  Persons  may  lend
portfolio securities to brokers,  banks or other financial  institutions.  These
loans  typically  obligate  the borrower to return the  securities,  or an equal
amount of securities of the same class, to the lender and typically provide that
the borrower is entitled to exercise voting rights and retain  dividends  during
the term of the loan.  From time to time, to the extent  permitted by applicable
law, each of the Reporting Persons may borrow securities,  including the Shares,
for the purpose of effecting,  and may effect, short sale transactions,  and may
purchase  securities for the purpose of closing out short sale positions in such
securities.

                  The foregoing  descriptions of the Subscription Agreement does
not purport to be complete and are  qualified in their  entirety by the terms of
such document which is incorporated herein by reference.

                  Except as otherwise set forth herein, the Reporting Persons do
not have any  contracts,  arrangements,  understandings  or  relationships  with
respect to any securities of the Issuer.




                                                             Page 10 of 13 Pages

Item 7.           Material to be filed as Exhibits.

                  The Exhibit Index is incorporated by reference.






                                                             Page 11 of 13 Pages


                                   SIGNATURES

         After reasonable inquiry and to the best of my knowledge and belief,
the undersigned certifies that the information set forth in this Statement is
true, complete and correct.

Date: May 19, 2004               MHR CAPITAL PARTNERS LP

                                 By: MHR Advisors LLC,
                                     its General Partner

                                 By: /s/ Hal Goldstein
                                     --------------------------
                                     Name:    Hal Goldstein,
                                     Title:   Vice President


                                 MRL PARTNERS LP

                                 By: MHR Advisors LLC,
                                     its General Partner

                                 By: /s/ Hal Goldstein
                                     ----------------------------
                                     Name:    Hal Goldstein,
                                     Title:   Vice President

                                 OTT LLC


                                 By: /s/ Hal Goldstein
                                     ----------------------------
                                     Name:    Hal Goldstein
                                     Title:   Authorized Signatory

                                 MHR ADVISORS


                                 By: /s/ Hal Goldstein
                                     ----------------------------
                                     Name:    Hal Goldstein,
                                     Title:   Vice President

                                 MARK H. RACHESKY, M.D.


                                 By: /s/ Mark H. Rachesky, M.D.
                                     ----------------------------



                                                             Page 12 of 13 Pages

                                     ANNEX A
                    RECENT TRANSACTIONS IN THE SECURITIES OF
                            NEOSE TECHNOLOGIES, INC.

                           Date of      Nature of     Number of
For the Account of       Transaction    Transaction   Securities           Price
------------------       -----------    -----------   ----------           -----

MHR Capital Partners     May 17, 2004      Buy        738,552 Shares       $6.77




                                                             Page 13 of 13 Pages

                                  EXHIBIT INDEX

Exhibit                                                                 Page No.
-------                                                                 --------

7.3           Form of the Subscription Agreement, by and between
              Neose Technologies,  Inc. and the Investor /1/





----------------------------------------
/1/      Filed  on  May 19, 2004  as  Exhibit A  to Exhibit 99.2 to the Issuer's
         current report on Form 8-K (Commission File Number 000-27718)