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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934
(Amendment No. __)*

XCYTE THERAPIES, INC.

(Name of Issuer)

Common Stock

(Title of Class of Securities)

98389F 10 1

(CUSIP Number)

December 31, 2004

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

        o Rule 13d-1 (b)

        o Rule 13d-1 (c)

        þ Rule 13d-1 (d)

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the notes).

 

 

             
13G
CUSIP No. 98389F 10 1
  1. Name of Reporting Person:
MPM BioVentures II, L.P.		 I.R.S. Identification Nos. of above persons (entities only):
  2. Check the Appropriate Box if a Member of a Group:
    (a) o  
    (b) þ  
  3. SEC Use Only:
  4. Citizenship or Place of Organization:
Delaware
Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
5. Sole Voting Power:
87,744
6. Shared Voting Power:
0
7. Sole Dispositive Power:
87,744
8.Shared Dispositive Power:
0
  9.Aggregate Amount Beneficially Owned by Each Reporting Person:
87,744
  10.Check if the Aggregate Amount in Row (9) Excludes Certain Shares:
o
  11.Percent of Class Represented by Amount in Row (9):
0.5%
  12.Type of Reporting Person:
PN

Page 2 of 12

 

             
13G
CUSIP No. 98389F 10 1
  1. Name of Reporting Person:
MPM BioVentures II-QP, L.P.		 I.R.S. Identification Nos. of above persons (entities only):
  2. Check the Appropriate Box if a Member of a Group:
    (a) o  
    (b) þ  
  3. SEC Use Only:
  4. Citizenship or Place of Organization:
Delaware
Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
5. Sole Voting Power:
795,030
6. Shared Voting Power:
0
7. Sole Dispositive Power:
795,030
8.Shared Dispositive Power:
0
  9.Aggregate Amount Beneficially Owned by Each Reporting Person:
795,030
  10.Check if the Aggregate Amount in Row (9) Excludes Certain Shares:
o
  11.Percent of Class Represented by Amount in Row (9):
4.8%
  12.Type of Reporting Person:
PN

Page 3 of 12

 

             
13G
CUSIP No. 98389F 10 1
  1. Name of Reporting Person:
MPM BioVentures GmbH & Co. Parallel-Beteiligungs KG		 I.R.S. Identification Nos. of above persons (entities only):
  2. Check the Appropriate Box if a Member of a Group:
    (a) o  
    (b) þ  
  3. SEC Use Only:
  4. Citizenship or Place of Organization:
Germany
Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
5. Sole Voting Power:
279,889
6. Shared Voting Power:
0
7. Sole Dispositive Power:
279,889
8.Shared Dispositive Power:
0
  9.Aggregate Amount Beneficially Owned by Each Reporting Person:
279,889
  10.Check if the Aggregate Amount in Row (9) Excludes Certain Shares:
o
  11.Percent of Class Represented by Amount in Row (9):
1.7%
  12.Type of Reporting Person:
PN

Page 4 of 12

 

             
13G
CUSIP No. 98389F 10 1
  1. Name of Reporting Person:
MPM Asset Management Investors 2000B, LLC		 I.R.S. Identification Nos. of above persons (entities only):
  2. Check the Appropriate Box if a Member of a Group:
    (a) o  
    (b) þ  
  3. SEC Use Only:
  4. Citizenship or Place of Organization:
Delaware
Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
5. Sole Voting Power:
18,302
6. Shared Voting Power:
0
7. Sole Dispositive Power:
18,302
8.Shared Dispositive Power:
0
  9.Aggregate Amount Beneficially Owned by Each Reporting Person:
18,302
  10.Check if the Aggregate Amount in Row (9) Excludes Certain Shares:
o
  11.Percent of Class Represented by Amount in Row (9):
0.1%
  12.Type of Reporting Person:
OO

Page 5 of 12

 

             
13G
CUSIP No. 98389F 10 1
  1. Name of Reporting Person:
Ansbert Gadicke		 I.R.S. Identification Nos. of above persons (entities only):
  2. Check the Appropriate Box if a Member of a Group:
    (a) o  
    (b) þ  
  3. SEC Use Only:
  4. Citizenship or Place of Organization:
United States
Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
5. Sole Voting Power:
0
6. Shared Voting Power:
1,180,965*
7. Sole Dispositive Power:
0
8.Shared Dispositive Power:
1,180,965*
  9.Aggregate Amount Beneficially Owned by Each Reporting Person:
1,180,965*
  10.Check if the Aggregate Amount in Row (9) Excludes Certain Shares:
o
  11.Percent of Class Represented by Amount in Row (9):
7.1%
  12.Type of Reporting Person:
IN
* The shares are held as follows: 87,744 shares by MPM BioVentures II, L.P. (“BV II”), 795,030 shares by MPM BioVentures II-QP, L.P. (“BV QP”), 279,889 shares by MPM BioVentures GmbH & Co. Parallel Beteiligungs KG (“BV KG”) and 18,302 shares MPM Asset Management Investors 2000B LLC (“AM LLC”). MPM Asset Management II LP (“AM II LP”) and MPM Asset Management II LLC (“AM II LLC”) are the direct and indirect general partners of BV II, BV QP and BV KG. The Reporting Person is a member of AM II LLC and AM LLC.

Page 6 of 12

 

             
13G
CUSIP No. 98389F 10 1
  1. Name of Reporting Person:
Luke Evnin		 I.R.S. Identification Nos. of above persons (entities only):
  2. Check the Appropriate Box if a Member of a Group:
    (a) o  
    (b) þ  
  3. SEC Use Only:
  4. Citizenship or Place of Organization:
United States
Number of
Shares
Beneficially
Owned by
Each Reporting
Person With
5. Sole Voting Power:
0
6. Shared Voting Power:
1,180,965*
7. Sole Dispositive Power:
0
8.Shared Dispositive Power:
1,180,965*
  9.Aggregate Amount Beneficially Owned by Each Reporting Person:
1,180,965*
  10.Check if the Aggregate Amount in Row (9) Excludes Certain Shares:
o
  11.Percent of Class Represented by Amount in Row (9):
7.1%
  12.Type of Reporting Person:
IN
* The shares are held as follows: 87,744 shares by MPM BioVentures II, L.P. (“BV II”), 795,030 shares by MPM BioVentures II-QP, L.P. (“BV QP”), 279,889 shares by MPM BioVentures GmbH & Co. Parallel Beteiligungs KG (“BV KG”) and 18,302 shares MPM Asset Management Investors 2000B LLC (“AM LLC”). MPM Asset Management II LP (“AM II LP”) and MPM Asset Management II LLC (“AM II LLC”) are the direct and indirect general partners of BV II, BV QP and BV KG. The Reporting Person is a member of AM II LLC and AM LLC.

Page 7 of 12

 

             
Item 1.
            
 
   (a)   Name of Issuer
 
       Xcyte Therapies, Inc.
 
            
 
   (b)   Address of Issuer’s Principal Executive Offices
1124 Columbia Street, Suite 130
Seattle, WA 98104
Item 2.
            
 
            
 
   (a)   Name of Person Filing
          MPM BioVentures II, LP
MPM BioVentures II-QP, L.P.
MPM BioVentures GmbH & Co Parallel-Beteiligungs KG
MPM Asset Management Investors 2000B, LLC
Ansbert Gadicke
Luke Evnin
 
            
 
   (b)   Address of Principal Business Office or, if none, Residence
          c/o MPM Capital L.P.
111 Huntington Avenue, 31st floor
Boston, MA 02199
 
            
 
   (c)   Citizenship
          All entities were organized in Delaware, except MPM BioVentures GmbH & Co Parallel-Beteiligungs KG which was organized in Germany. All individuals are United States citizens.
 
            
 
   (d)   Title of Class of Securities
 
            Common Stock
 
            
 
   (e)   CUSIP Number
     98389F 10 1
 
            
Item 3.
   If this statement is filed pursuant to §§240.13d-1(b), or 240.13d-2(b) or (c), check whether the person filing is a:
      Not applicable
 
            
Item 4.
   Ownership
 
            
 
   (a)   Amount Beneficially Owned:
         
MPM BioVentures II, LP
    87,744  
MPM BioVentures II-QP, L.P.
    795,030  
MPM BioVentures GmbH & Co Parallel-Beteiligungs KG
    279,889  
MPM Asset Management Investors 2000B, LLC
    18,302  
Ansbert Gadicke
    1,180,965*  
Luke Evnin
    1,180,965*  

Page 8 of 12

 

     Percent of Class:

         
MPM BioVentures II, LP
    0.5 %
MPM BioVentures II-QP, L.P.
    4.8 %
MPM BioVentures GmbH & Co Parallel-Beteiligungs KG
    1.7 %
MPM Asset Management Investors 2000B, LLC
    0.1 %
Ansbert Gadicke
    7.1 %
Luke Evnin
    7.1 %

  (b)   Number of shares as to which the person has:

  (i)   Sole power to vote or to direct the vote
         
MPM BioVentures II, LP
    87,744  
MPM BioVentures II-QP, L.P.
    795,030  
MPM BioVentures GmbH & Co Parallel-Beteiligungs KG
    279,889  
MPM Asset Management Investors 2000B, LLC
    18,302  
Ansbert Gadicke
    0  
Luke Evnin
    0  

  (ii)   Shared power to vote or to direct the vote
         
MPM BioVentures II, LP
    0  
MPM BioVentures II-QP, L.P.
    0  
MPM BioVentures GmbH & Co Parallel-Beteiligungs KG
    0  
MPM Asset Management Investors 2000B, LLC
    0  
Ansbert Gadicke
    1,180,965*  
Luke Evnin
    1,180,965*  

  (iii)   Sole power to dispose or to direct the disposition of
         
MPM BioVentures II, LP
    87,744  
MPM BioVentures II-QP, L.P.
    795,030  
MPM BioVentures GmbH & Co Parallel-Beteiligungs KG
    279,889  
MPM Asset Management Investors 2000B, LLC
    18,302  
Ansbert Gadicke
    0  
Luke Evnin
    0  

  (iv)   Shared power to dispose or to direct the disposition of
         
MPM BioVentures II, LP
    0  
MPM BioVentures II-QP, L.P.
    0  
MPM BioVentures GmbH & Co Parallel-Beteiligungs KG
    0  
MPM Asset Management Investors 2000B, LLC
    0  
Ansbert Gadicke
    1,180,965*  
Luke Evnin
    1,180,965*  

Page 9 of 12

 

* The shares are held as follows: 87,744 shares by MPM BioVentures II, L.P. (“BV II”), 795,030 shares by MPM BioVentures II-QP, L.P. (“BV QP”), 279,889 shares by MPM BioVentures GmbH & Co. Parallel Beteiligungs KG (“BV KG”) and 18,302 shares MPM Asset Management Investors 2000B LLC (“AM LLC”). MPM Asset Management II LP (“AM II LP”) and MPM Asset Management II LLC (“AM II LLC”) are the direct and indirect general partners of BV II, BV QP and BV KG. The Reporting Person is a member of AM II LLC and AM LLC.

         
Item 5.
      Ownership of Five Percent or Less of a Class
 
        
If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following o.
 
        
Item 6.
      Ownership of More than Five Percent on Behalf of Another Person
 
        
 
   Not Applicable
 
        
Item 7.
      Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.
 
        
 
   Not Applicable
 
        
Item 8.
      Identification and Classification of Members of the Group
 
        
 
   Not Applicable
 
        
Item 9.
      Notice of Dissolution of a Group
 
        
 
   Not Applicable
 
        
Item 10.
      Certification
 
        
 
   Not Applicable

Page 10 of 12

 

SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: February 9, 2005

                 
MPM BIOVENTURES II, L.P.
       MPM BIOVENTURES II-QP, L.P.
 
                
By:
  MPM Asset Management II, L.P.,       By:   MPM Asset Management II, L.P.,
  its General Partner           its General Partner
 
                
By:
  MPM Asset Management II LLC,       By:   MPM Asset Management II LLC,
  its General Partner           its General Partner
 
                
By:
       Luke B. Evnin       By:        Luke B. Evnin
               
  Name: Luke B. Evnin           Name: Luke B. Evnin
  Title: Manager           Title: Manager
 
                
MPM CAPITAL GMBH. & CO. PARALLEL-
       MPM ASSET MANAGEMENT INVESTORS
BETEILIGUNGS KG
       2000B LLC
 
                
By:
  MPM Asset Management II LP, in its       By:        Luke B. Evnin
  capacity as the           Name: Luke B. Evnin
  Special Limited Partner           Title: Manager
               
 
                
By:
  MPM Asset Management II LLC, its            
  General Partner            
 
                
By:
  Luke B. Evnin            
               
  Name: Luke B. Evnin            
  Title: Manager            
 
                
By:
       /s/ Ansbert Gadicke       By:        /s/ Luke B. Evnin
               
  Name: Ansbert Gadicke           Name: Luke B. Evnin

Page 11 of 12

 

EXHIBIT A

JOINT FILING AGREEMENT

     In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the Common Stock of Xcyte Therapies, Inc. and further agree that this agreement be included as an exhibit to such filing. Each party to the agreement expressly authorizes each other party to file on its behalf any and all amendments to such statement. Each party to this agreement agrees that this joint filing agreement may be signed in counterparts.

     In evidence whereof, the undersigned have caused this Agreement to be executed on their behalf this 9th day of February, 2005.

                 
MPM BIOVENTURES II, L.P.
       MPM BIOVENTURES II-QP, L.P.
 
                
By:
  MPM Asset Management II, L.P.,       By:   MPM Asset Management II, L.P.,
  its General Partner           its General Partner
 
                
By:
  MPM Asset Management II LLC,       By:   MPM Asset Management II LLC,
  its General Partner           its General Partner
 
                
By:
       Luke B. Evnin       By:        Luke B. Evnin
               
  Name: Luke B. Evnin           Name: Luke B. Evnin
  Title: Manager           Title: Manager
 
                
MPM CAPITAL GMBH. & CO. PARALLEL-
       MPM ASSET MANAGEMENT INVESTORS
BETEILIGUNGS KG
       2000B LLC
 
                
By:
  MPM Asset Management II LP, in its       By:        Luke B. Evnin
  capacity as the           Name: Luke B. Evnin
  Special Limited Partner           Title: Manager
               
 
                
By:
  MPM Asset Management II LLC, its            
  General Partner            
 
                
By:
  Luke B. Evnin            
               
  Name: Luke B. Evnin            
  Title: Manager            
 
                
By:
       /s/ Ansbert Gadicke       By:        /s/ Luke B. Evnin
               
  Name: Ansbert Gadicke           Name: Luke B. Evnin

Page 12 of 12