Castle Biosciences Named a 2021 Houston Chronicle Top Workplace

Castle Biosciences, Inc. (Nasdaq: CSTL), a company applying innovative diagnostics to transform disease management and improve patient outcomes, today announced that the Company has been named a 2021 Houston Chronicle Top Workplace. Of the 2,768 companies in the Houston area who participated in the nomination process, only 175 companies were included in the Top Workplaces list.

“We are both honored and grateful to be recognized as a Top Workplace in Houston,” said Derek Maetzold, president and chief executive officer of Castle Biosciences. “We believe this award reflects our carefully cultivated effort to build and maintain a strong culture defined by patient-first values, respect, integrity and transparency.

“As a company, we are focused on improving the lives of patients by providing clinically actionable information to clinicians and their patients to inform disease management. And we acknowledge that it is our employees, through their hard work and dedication, who are making the difference. As we continue to grow our business, it is our priority to ensure that each employee feels valued and appreciated for what they bring to our organization.”

The Top Workplaces program starts with capturing employee feedback on what matters most about a company’s culture. The award winners were determined through an anonymous survey that measured fifteen drivers of company culture, as well as other insights related to each company’s leadership and employee engagement. Castle scored above the 75^th percentile among benchmark companies with respect to the percentage of employees who feel genuinely appreciated by the company, that they are part of a meaningful, company-wide mission and that the company is going in the right direction.

About Castle Biosciences

Castle Biosciences (Nasdaq: CSTL) is a commercial-stage diagnostics company focused on providing physicians and their patients with personalized, clinically actionable genomic information to make more accurate treatment decisions. The Company currently offers tests for patients with cutaneous melanoma (DecisionDx®-Melanoma, DecisionDx® -CMSeq), cutaneous squamous cell carcinoma (DecisionDx®-SCC), suspicious pigmented lesions (myPath® Melanoma, DecisionDx® DiffDx™-Melanoma) and uveal melanoma (DecisionDx®-UM, DecisionDx®-PRAME and DecisionDx®-UMSeq). For more information about Castle’s gene expression profile tests, visit www.CastleTestInfo.com.

Castle also has active research and development programs for tests in other dermatologic diseases with high clinical need, including its test in development to predict systemic therapy response in patients with moderate to severe psoriasis, atopic dermatitis and related conditions. Castle Biosciences is based in Friendswood, Texas (Houston), and has laboratory operations in Phoenix.

For more information, visit www.CastleBiosciences.com.

DecisionDx-Melanoma, DecisionDx-CMSeq, DecisionDx-SCC, myPath Melanoma, DecisionDx DiffDx-Melanoma, DecisionDx-UM, DecisionDx-PRAME and DecisionDx-UMSeq are trademarks of Castle Biosciences, Inc.

Forward-Looking Statements

The information in this press release contains forward-looking statements and information within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the “safe harbor” created by those sections. These forward-looking statements include, but are not limited to, statements concerning our ability to build and maintain a strong culture and continue to grow our business. The words “anticipates,” “believes,” “estimates,” “expects,” “intends,” “may,” “plans,” “projects,” “will,” “would” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements that we make. These forward-looking statements involve risks and uncertainties that could cause our actual results to differ materially from those in the forward-looking statements, including, without limitation, the effects of the COVID-19 pandemic on our business and our efforts to address its impact on our business and the risks set forth in our Quarterly Report on Form 10-Q for the quarter ended Sept. 30, 2021, and in our other filings with the SEC. The forward-looking statements are applicable only as of the date on which they are made, and we do not assume any obligation to update any forward-looking statements, except as may be required by law.

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