NanoString Launches Integrated Informatics to Facilitate Spatial Biology Research Using Next Generation Sequencing

GeoMx NextSeq workflow creates a streamlined end-to-end solution for spatial multiomic analysis, reducing user touchpoints, and the need for on-site informatics infrastructure

NanoString Technologies, Inc. (NASDAQ: NSTG), a leading provider of life science tools for discovery and translational research, today announced a seamless, cloud-based workflow that improves the spatial data analysis experience of customers using Illumina NextSeq™ 1000 and NextSeq™ 2000 sequencing systems and the GeoMx^® Digital Spatial Profiler. The spatial analysis of whole transcriptomes combined with proteome analytes can now be simplified using this integrated, push-button run planning tool.

The new integrated workflow allows GeoMx users to plan their NextSeq 1000/2000 sequencing runs using software on the GeoMx instrument and is coupled to automated downstream data processing using the DRAGEN™ Bio-IT platform, Illumina’s industry-leading platform for secondary data analysis. Upon completion of sequence processing, the spatially-resolved digital counts of RNA or protein are ported directly to the GeoMx system, allowing researchers to interact, visualize and analyze their multiomic data.

"As a company, we strive to create end-to-end spatial solutions that are simpler, faster, and more relevant to today's life science challenges," said John Gerace, Chief Commercial Officer, NanoString. "Working together with Illumina, we are ensuring the increasing volume of data is analyzed promptly and that the workflow between our companies' instruments is streamlined to improve customer experiences."

“Illumina is committed to enabling compatible and streamlined workflows with our partner solutions to ensure our customers can implement the workflows that best answer their research questions,” said Joel Fellis, VP of Sequencing Platforms Product Management, Illumina. “NanoString’s GeoMx Digital Spatial Profiler is enabling a new frontier in discovery research using whole transcriptome analysis and protein detection with spatial context.”

The release of the new integrated workflow complements a suite of previously released spatial genomics workflows from the NanoString and Illumina partnership. This includes the GeoMx NGS Pipeline with DRAGEN as a third-party application accessible on the BaseSpace™ Sequence Hub that enables easy coupling of the pipeline processing downstream from any Illumina sequencing platform. The team also co-developed an integrated local workflow with the release of the NanoString GeoMx NGS Pipeline on DRAGEN for NextSeq 1000/2000 platforms to enable customers whose instruments may not be networked. The full suite of streamlined NGS informatics workflows enables GeoMx customers to choose which one best meets their needs.

About NanoString Technologies, Inc

NanoString Technologies is a leading provider of life science tools for discovery and translational research. The company provides three platforms that allow researchers to map the universe of biology. The nCounter^® Analysis System, cited in more than 5,300 peer-reviewed publications, offers a way to easily profile the expression of hundreds of genes, proteins, miRNAs, or copy number variations, simultaneously with high sensitivity and precision. NanoString's GeoMx^® Digital Spatial Profiler enables highly multiplexed spatial profiling of RNA and protein targets in various sample types, including FFPE tissue sections, and has been cited in more than 100 peer-reviewed publications. The CosMx™ Spatial Molecular Imager, with commercial availability expected in 2022, enables highly sensitive, high-resolution imaging of hundreds to thousands of RNAs or proteins directly from single cells within morphologically intact whole tissue sections. For more information, visit www.nanostring.com.

Forward-Looking Statements

This news release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995. These forward-looking statements include statements regarding our products and the anticipated launch of new products and technology. Such statements are based on current assumptions that involve risks and uncertainties that could cause actual outcomes and results to differ materially. These risks and uncertainties, many of which are beyond our control, include market acceptance of our products; delays or denials of regulatory approvals or clearances for products or applications; the extent and duration of the impact of the COVID-19 pandemic and adverse conditions in the general domestic and global economic markets; the effects of ongoing litigation; the impact of competition; the impact of expanded sales, marketing, product development and clinical activities on operating expenses; delays or other unforeseen problems with respect to manufacturing and product development; as well as the other risks set forth in our filings with the Securities and Exchange Commission. These forward-looking statements speak only as of the date hereof. NanoString Technologies disclaims any obligation to update these forward-looking statements.

NanoString, NanoString Technologies, the NanoString logo, CosMx, GeoMx, and nCounter are trademarks or registered trademarks of NanoString Technologies, Inc. in various jurisdictions.

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