New York, USA - May 28, 2024 - The CellFace™ platform is one of the core technologies developed by Creative Biolabs, utilizing advanced biochemical methods to achieve efficient cell surface modification. The platform designs include various conjugation methods, multiple cell types, and solutions for conjugating cells with different biomolecules, offering customized technical services for client projects.
"Creative Biolabs has always been focused on the forefront of cell therapy," according to an expert at Creative Biolabs. "With this innovative one-stop platform, we demonstrate the new vitality that cell surface engineering technology injects into cell therapy."
Considering conjugation methods, Creative Biolabs designs cell-covalent and non-covalent conjugations within this platform. The chemical bonds formed by cell-covalent conjugation are stable and capable of lasting in vivo for extended periods. Additionally, it ensures controllability, allowing precise control over the binding location and quantity, ensuring consistency and functionality of the modifications.
"We offer various cell-covalent conjugation strategies," the expert explained, "to meet different research needs and application scenarios. For example, direct chemical conjugation using amine reaction strategies. This involves reacting amine groups on the cell surface with reactive groups on functional molecules to form stable covalent bonds."
Creative Biolabs also proposes indirect conjugation methods within their cell-covalent binding schemes. For instance, enzyme-mediated strategies that use enzymatic reactions to link functional molecules to the cell surface, and metabolic-mediated strategies that introduce modifying molecules into cells through metabolic pathways, which then express and bind on the cell surface.
Creative Biolabs also offers a range of cell-noncovalent physical bioconjugation services, utilizing physical and chemical methods to bind functional molecules to the cell surface without forming covalent bonds, thus avoiding damage to the cells.
These solutions include:
Biotinylation Binding: Using the strong affinity between biotin and avidin to attach functional molecules to the cell surface. This method is particularly suitable for experiments requiring multiple labeling or modifications.
Electrostatic Interaction Modification: Utilizing the electrostatic attraction between charged groups on the cell surface and oppositely charged functional molecules for binding. This strategy is often used for attaching peptides or proteins to study cell behavior and function.
Lipid Membrane Insertion: Inserting the hydrophobic tails of lipid molecules into the hydrophobic interior of the cell membrane to bind functional molecules to the cell surface, commonly used for cell imaging and targeted therapy.
Hydrophobic Insertion: Using the interaction between hydrophobic molecules and the lipid bilayer of the cell membrane to embed molecules into the cell membrane, enabling efficient molecular binding without altering the cell membrane structure.
"In addition to the classification by conjugation methods, Creative Biolabs also supports the conjugation of cells with various biomolecules, such as cell-antibody conjugation, cell-drug conjugation, and cell-fluorescent protein conjugation," the expert added.
For more customized cell surface engineering services, please visit https://cellface-conjugate.creative-biolabs.com.
About
Creative Biolabs is a globally leading biotechnology company focused on the development of cell surface engineering and cell therapy. With years of industry experience and technical accumulation, Creative Biolabs is committed to providing the highest quality products and services for research projects.
Media Contact
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Phone: 1-631-830-6441
Country: United States
Website: https://cellface-conjugate.creative-biolabs.com
